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Results: 1-12 |
Results: 12
Synthesis of 2,4-diamino-6-(thioarylmethyl)pyrido [2,3-d]pyrimidines as dihydrofolate reductase inhibitors
Authors: Gangjee, A Adair, O Queener, SF
Citation: A. Gangjee et al., Synthesis of 2,4-diamino-6-(thioarylmethyl)pyrido [2,3-d]pyrimidines as dihydrofolate reductase inhibitors, BIO MED CH, 9(11), 2001, pp. 2929-2935
Synthesis, antifolate, and antitumor activities of classical and nonclassical 2-amino-4-oxo-5-substituted-pyrrolo[2,3-d]pyrimidines
Authors: Gangjee, A Vidwans, A Elzein, E McGuire, JJ Queener, SF Kisliuk, RL
Citation: A. Gangjee et al., Synthesis, antifolate, and antitumor activities of classical and nonclassical 2-amino-4-oxo-5-substituted-pyrrolo[2,3-d]pyrimidines, J MED CHEM, 44(12), 2001, pp. 1993-2003
Synthesis of novel, nonclassical 2-amino-4-oxo-6(arylthio)ethylpyrrolo[2,3-d]pyrimidines as potential inhibitors of thymidylate synthase
Authors: Gangjee, A Dubash, NP Kisliuk, RL
Citation: A. Gangjee et al., Synthesis of novel, nonclassical 2-amino-4-oxo-6(arylthio)ethylpyrrolo[2,3-d]pyrimidines as potential inhibitors of thymidylate synthase, J HETERO CH, 38(2), 2001, pp. 349-354
Conformationally restricted tricyclic analogues of lipophilic pyrido[2,3-d]pyrimidine antifolates
Authors: Gangjee, A Mavandadi, F Queener, SF
Citation: A. Gangjee et al., Conformationally restricted tricyclic analogues of lipophilic pyrido[2,3-d]pyrimidine antifolates, J HETERO CH, 38(1), 2001, pp. 213-220
Design, synthesis, and X-ray crystal structure of a potent dual inhibitor of thymidylate synthase and dihydrofolate reductase as an antitumor agent
Authors: Gangjee, A Yu, JM McGuire, JJ Cody, V Galitsky, N Kisliuk, RL Queener, SF
Citation: A. Gangjee et al., Design, synthesis, and X-ray crystal structure of a potent dual inhibitor of thymidylate synthase and dihydrofolate reductase as an antitumor agent, J MED CHEM, 43(21), 2000, pp. 3837-3851
Effect of C9-methyl substitution and C8-C9 conformational restriction on antifolate and antitumor activity of classical 5-substituted 2,4-diaminofuro[2,3-d] pyrimidines
Authors: Gangjee, A Zeng, YB McGuire, JJ Kisliuk, RL
Citation: A. Gangjee et al., Effect of C9-methyl substitution and C8-C9 conformational restriction on antifolate and antitumor activity of classical 5-substituted 2,4-diaminofuro[2,3-d] pyrimidines, J MED CHEM, 43(16), 2000, pp. 3125-3133
The synthesis of novel nonclassical reversed bridge quinazoline antifolates as inhibitors of thymidylate synthase [1a,b]
Authors: Gangjee, A Kothare, M Kisliuk, RL
Citation: A. Gangjee et al., The synthesis of novel nonclassical reversed bridge quinazoline antifolates as inhibitors of thymidylate synthase [1a,b], J HETERO CH, 37(5), 2000, pp. 1097-1102
The synthesis of new 2,4-diaminofuro[2,3-d]pyrimidines with 5-biphenyl, phenoxyphenyl and tricyclic substitutions as dihydrofolate reductase inhibitors
Authors: Gangjee, A Dubash, NP Queener, SF
Citation: A. Gangjee et al., The synthesis of new 2,4-diaminofuro[2,3-d]pyrimidines with 5-biphenyl, phenoxyphenyl and tricyclic substitutions as dihydrofolate reductase inhibitors, J HETERO CH, 37(4), 2000, pp. 935-942
Reactions of 6-aminopyrimidines with biselectrophiles: Manipulation of product composition with solvent and pyrimidine substitution variation
Authors: Vasudevan, A Mavandadi, F Chen, LH Gangjee, A
Citation: A. Vasudevan et al., Reactions of 6-aminopyrimidines with biselectrophiles: Manipulation of product composition with solvent and pyrimidine substitution variation, J ORG CHEM, 64(2), 1999, pp. 634-638
Pneumocystis carinii and Toxoplasma gondii dihydrofolate reductase inhibitors and antitumor agents: Synthesis and biological activities of 2,4-diamino-5-methyl-6-[(monosubstituted anilino)methyl]pyrido[2,3-d]pyrimidines
Authors: Gangjee, A Adair, O Queener, SF
Citation: A. Gangjee et al., Pneumocystis carinii and Toxoplasma gondii dihydrofolate reductase inhibitors and antitumor agents: Synthesis and biological activities of 2,4-diamino-5-methyl-6-[(monosubstituted anilino)methyl]pyrido[2,3-d]pyrimidines, J MED CHEM, 42(13), 1999, pp. 2447-2455
Synthesis of classical and a nonclassical 2-amino-4-oxo-6-methyl-5-substituted pyrrolo[2,3-d]pyrimidine antifolate inhibitors of thymidylate synthase
Authors: Gangjee, A Mavandadi, F Kisliuk, RL Queener, SF
Citation: A. Gangjee et al., Synthesis of classical and a nonclassical 2-amino-4-oxo-6-methyl-5-substituted pyrrolo[2,3-d]pyrimidine antifolate inhibitors of thymidylate synthase, J MED CHEM, 42(12), 1999, pp. 2272-2279
Unusual dihydrazone formation in the Fischer-indole cyclization. The synthesis of novel nonclassical annulated 2,4-diaminopyrrolo[2,3-d]pyrimidine antifolates
Authors: Gangjee, A Chen, LH
Citation: A. Gangjee et Lh. Chen, Unusual dihydrazone formation in the Fischer-indole cyclization. The synthesis of novel nonclassical annulated 2,4-diaminopyrrolo[2,3-d]pyrimidine antifolates, J HETERO CH, 36(2), 1999, pp. 441-444
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