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Results: 1-25 | 26-28
Results: 1-25/28
Novel allosteric antagonists shed light on mglu(5) receptors and CNS disorders
Authors: Spooren, WPJM Gasparini, F Salt, TE Kuhn, R
Citation: Wpjm. Spooren et al., Novel allosteric antagonists shed light on mglu(5) receptors and CNS disorders, TRENDS PHAR, 22(7), 2001, pp. 331-337
Design, synthesis and preliminary evaluation of novel 3 '-substituted carboxycyclopropylglycines as antagonists at group 2 metabotropic glutamate receptors
Authors: Pellicciari, R Costantino, G Marinozzi, M Macchiarulo, A Amori, L Flor, PJ Gasparini, F Kuhn, R Urwyler, S
Citation: R. Pellicciari et al., Design, synthesis and preliminary evaluation of novel 3 '-substituted carboxycyclopropylglycines as antagonists at group 2 metabotropic glutamate receptors, BIOORG MED, 11(24), 2001, pp. 3179-3182
An activity-dependent switch from facilitation to inhibition in the control of excitotoxicity by group I metabotropic glutamate receptors
Authors: Bruno, V Battaglia, G Copani, A Cespedes, VM Galindo, MF Cena, V Sanchez-Prieto, J Gasparini, F Kuhn, R Flor, PJ Nicoletti, F
Citation: V. Bruno et al., An activity-dependent switch from facilitation to inhibition in the control of excitotoxicity by group I metabotropic glutamate receptors, EUR J NEURO, 13(8), 2001, pp. 1469-1478
Increased seizure susceptibility in mice lacking metabotropic glutamate receptor 7
Authors: Sansig, G Bushell, TJ Clarke, VRJ Rozov, A Burnashev, N Portet, C Gasparini, F Schmutz, M Klebs, K Shigemoto, R Flor, PJ Kuhn, R Knoepfel, T Schroeder, M Hampson, DR Collett, VJ Zhang, CX Duvoisin, RM Collingridge, GL van der Putten, H
Citation: G. Sansig et al., Increased seizure susceptibility in mice lacking metabotropic glutamate receptor 7, J NEUROSC, 21(22), 2001, pp. 8734-8745
Optimal coded aperture patterns for improved SNR in nuclear medicine imaging
Authors: Accorsi, R Gasparini, F Lanza, RC
Citation: R. Accorsi et al., Optimal coded aperture patterns for improved SNR in nuclear medicine imaging, NUCL INST A, 474(3), 2001, pp. 273-284
Test of the wire ageing induced by radiation for the CMS barrel muon chambers
Authors: Conti, E Gasparini, F
Citation: E. Conti et F. Gasparini, Test of the wire ageing induced by radiation for the CMS barrel muon chambers, NUCL INST A, 465(2-3), 2001, pp. 472-481
Glutamate release inhibiting properties of the novel mGlu(5) receptor antagonist 2-methyl-6-(phenylethynyl)-pyridine (MPEP): complementary in vitro and in vivo evidence
Authors: Thomas, LS Jane, DE Gasparini, F Croucher, MJ
Citation: Ls. Thomas et al., Glutamate release inhibiting properties of the novel mGlu(5) receptor antagonist 2-methyl-6-(phenylethynyl)-pyridine (MPEP): complementary in vitro and in vivo evidence, NEUROPHARM, 41(4), 2001, pp. 523-527
The metabotropic glutamate receptor antagonist 2-methyl-6-(phenylethynyl)-pyridine (MPEP) blocks fear conditioning in rats
Authors: Schulz, B Fendt, M Gasparini, F Lingenhohl, K Kuhn, R Koch, M
Citation: B. Schulz et al., The metabotropic glutamate receptor antagonist 2-methyl-6-(phenylethynyl)-pyridine (MPEP) blocks fear conditioning in rats, NEUROPHARM, 41(1), 2001, pp. 1-7
Metabotropic glutamate receptor subtype 5 (mGlu5) and nociceptive functionI. Selective blockade of mGlu5 receptors in models of acute, persistent and chronic pain
Authors: Walker, K Bowes, M Panesar, M Davis, A Gentry, C Kesingland, A Gasparini, F Spooren, W Stoehr, N Pagano, A Flor, PJ Vranesic, I Lingenhoehl, K Johnson, EC Varney, M Urban, L Kuhn, R
Citation: K. Walker et al., Metabotropic glutamate receptor subtype 5 (mGlu5) and nociceptive functionI. Selective blockade of mGlu5 receptors in models of acute, persistent and chronic pain, NEUROPHARM, 40(1), 2001, pp. 1-9
mGlu5 receptors and nociceptive function II. mGlu5 receptors functionally expressed on peripheral sensory neurones mediate inflammatory hyperalgesia
Authors: Walker, K Reeve, A Bowes, M Winter, J Wotherspoon, G Davis, A Schmid, P Gasparini, F Kuhn, R Urban, L
Citation: K. Walker et al., mGlu5 receptors and nociceptive function II. mGlu5 receptors functionally expressed on peripheral sensory neurones mediate inflammatory hyperalgesia, NEUROPHARM, 40(1), 2001, pp. 10-19
Potential anxiolytic- and antidepressant-like effects of MPEP, a potent, selective and systemically active mGlu5 receptor antagonist
Authors: Tatarczynska, E Klodzinska, A Chojnacka-Wojcik, E Palucha, A Gasparini, F Kuhn, R Pilc, A
Citation: E. Tatarczynska et al., Potential anxiolytic- and antidepressant-like effects of MPEP, a potent, selective and systemically active mGlu5 receptor antagonist, BR J PHARM, 132(7), 2001, pp. 1423-1430
Synthesis, molecular modeling and preliminary biological evaluation of 1-amino-3-phosphono-3-cyclopentene-1-carboxylic acid and 1-amino-3-phosphono-2-cyclopentene-1-carboxylic acid, two novel agonists of metabotropic glutamate receptors of group III
Authors: Amori, L Costantino, G Marinozzi, M Pellicciari, R Gasparini, F Flor, PJ Kuhn, R Vranesic, I
Citation: L. Amori et al., Synthesis, molecular modeling and preliminary biological evaluation of 1-amino-3-phosphono-3-cyclopentene-1-carboxylic acid and 1-amino-3-phosphono-2-cyclopentene-1-carboxylic acid, two novel agonists of metabotropic glutamate receptors of group III, BIOORG MED, 10(13), 2000, pp. 1447-1450
(+)-4-phosphonophenylglycine (PPG) a new group III selective metabotropic glutamate receptor agonist
Authors: Gasparini, F Inderbitzin, W Francotte, E Lecis, G Richert, P Dragic, Z Kuhn, R Flor, PJ
Citation: F. Gasparini et al., (+)-4-phosphonophenylglycine (PPG) a new group III selective metabotropic glutamate receptor agonist, BIOORG MED, 10(11), 2000, pp. 1241-1244
Selective activation of mGlu4 metabotropic glutamate receptors is protective against excitotoxic neuronal death
Authors: Bruno, V Battaglia, G Ksiazek, I van der Putten, H Catania, MV Giuffrida, R Lukic, S Leonhardt, T Inderbitzin, W Gasparini, F Kuhn, R Hampson, DR Nicoletti, F Flor, PJ
Citation: V. Bruno et al., Selective activation of mGlu4 metabotropic glutamate receptors is protective against excitotoxic neuronal death, J NEUROSC, 20(17), 2000, pp. 6413-6420
Distinct influence of the group III metabotropic glutamate receptor agonist (R,S)-4-phosphonophenylglycine [(R,S)-PPG] on different forms of neuronaldamage
Authors: Henrich-Noack, P Flor, PJ Sabelhaus, CF Prass, K Dirnagl, U Gasparini, F Sauter, A Rudin, M Reymann, KG
Citation: P. Henrich-noack et al., Distinct influence of the group III metabotropic glutamate receptor agonist (R,S)-4-phosphonophenylglycine [(R,S)-PPG] on different forms of neuronaldamage, NEUROPHARM, 39(5), 2000, pp. 911-917
Selective blockade of metabotropic glutamate receptor subtype 5 is neuroprotective
Authors: Bruno, V Ksiazek, I Battaglia, G Lukic, S Leonhardt, T Sauer, D Gasparini, F Kuhn, R Nicoletti, F Flor, PJ
Citation: V. Bruno et al., Selective blockade of metabotropic glutamate receptor subtype 5 is neuroprotective, NEUROPHARM, 39(12), 2000, pp. 2223-2230
Anxiolytic-like effects of the prototypical metabotropic glutamate receptor 5 antagonist 2-methyl-6-(phenylethynyl)pyridine in rodents
Authors: Spooren, WPJM Vassout, A Neijt, HC Kuhn, R Gasparini, F Roux, S Porsolt, RD Gentsch, C
Citation: Wpjm. Spooren et al., Anxiolytic-like effects of the prototypical metabotropic glutamate receptor 5 antagonist 2-methyl-6-(phenylethynyl)pyridine in rodents, J PHARM EXP, 295(3), 2000, pp. 1267-1275
Chiral resolution, pharmacological characterization, and receptor docking of the noncompetitive mGlu1 receptor antagonist (+/-)-2-hydroxyimino-1a,2-dihydro-1H-7-oxacyclopropa[b]naphthalene-7a-carboxylic acid ethyl ester
Authors: Ott, D Floersheim, P Inderbitzin, W Stoehr, N Francotte, E Lecis, G Richert, P Rihs, G Flor, PJ Kuhn, R Gasparini, F
Citation: D. Ott et al., Chiral resolution, pharmacological characterization, and receptor docking of the noncompetitive mGlu1 receptor antagonist (+/-)-2-hydroxyimino-1a,2-dihydro-1H-7-oxacyclopropa[b]naphthalene-7a-carboxylic acid ethyl ester, J MED CHEM, 43(23), 2000, pp. 4428-4436
The non-competitive antagonists 2-methyl-6-(phenylethynyl)pyridine and 7-hydroxyiminocyclopropan [b]chromen-1 alpha-carboxylic acid ethyl ester interact with overlapping binding pockets in the transmembrane region of group Imetabotropic glutamate receptors
Authors: Pagano, A Ruegg, D Litschig, S Stoehr, N Stierlin, C Heinrich, M Floersheim, P Prezeau, L Carroll, F Pin, JP Cambria, A Vranesic, I Flor, PJ Gasparini, F Kuhn, R
Citation: A. Pagano et al., The non-competitive antagonists 2-methyl-6-(phenylethynyl)pyridine and 7-hydroxyiminocyclopropan [b]chromen-1 alpha-carboxylic acid ethyl ester interact with overlapping binding pockets in the transmembrane region of group Imetabotropic glutamate receptors, J BIOL CHEM, 275(43), 2000, pp. 33750-33758
Effects of the prototypical mGlu(5) receptor antagonist 2-methyl-6-(phenylethynyl)-pyridine on rotarod, locomotor activity and rotational responses in unilateral 6-OHDA-lesioned rats
Authors: Spooren, WPJM Gasparini, F Bergmann, R Kuhn, R
Citation: Wpjm. Spooren et al., Effects of the prototypical mGlu(5) receptor antagonist 2-methyl-6-(phenylethynyl)-pyridine on rotarod, locomotor activity and rotational responses in unilateral 6-OHDA-lesioned rats, EUR J PHARM, 406(3), 2000, pp. 403-410
Lack of effect of LY314582 (a group 2 metabotropic glutamate receptor agonist) on phencyclidine-induced locomotor activity in metabotropic glutamate receptor 2 knockout mice
Authors: Spooren, WPJM Gasparini, F van der Putten, H Koller, M Nakanishi, S Kuhn, R
Citation: Wpjm. Spooren et al., Lack of effect of LY314582 (a group 2 metabotropic glutamate receptor agonist) on phencyclidine-induced locomotor activity in metabotropic glutamate receptor 2 knockout mice, EUR J PHARM, 397(1), 2000, pp. R1-R2
Flood events, a multiple basin response to precipitation events at different scales
Authors: Symader, W Bierl, R Gasparini, F
Citation: W. Symader et al., Flood events, a multiple basin response to precipitation events at different scales, ACT HYDR HY, 27(2), 1999, pp. 87-93
Test results off he ASIC front-end trigger prototypes for the muon barrel detector of CMS at LHC
Authors: De Giorgi, M Grandi, C Dosselli, U Gasparini, F Gasparini, U Gonella, F Guaita, P Lippi, I Meneguzzo, A Passaseo, M Pegoraro, M Ronchese, P Sancho, AJP Martinelli, R Torassa, E Ventura, L Zotto, P Zumerle, G
Citation: M. De Giorgi et al., Test results off he ASIC front-end trigger prototypes for the muon barrel detector of CMS at LHC, NUCL INST A, 438(2-3), 1999, pp. 302-316
2-methyl-6-(phenylethynyl)-pyridine (MPEP), a potent, selective and systemically active mGlu5 receptor antagonist
Authors: Gasparini, F Lingenhohl, K Stoehr, N Flor, PJ Heinrich, M Vranesic, I Biollaz, M Allgeier, H Heckendorn, R Urwyler, S Varney, MA Johnson, EC Hess, SD Rao, SP Sacaan, AI Santori, EM Velicelebi, G Kuhn, R
Citation: F. Gasparini et al., 2-methyl-6-(phenylethynyl)-pyridine (MPEP), a potent, selective and systemically active mGlu5 receptor antagonist, NEUROPHARM, 38(10), 1999, pp. 1493-1503
CPCCOEt, a noncompetitive metabotropic glutamate receptor 1 antagonist, inhibits receptor signaling without affecting glutamate binding
Authors: Litschig, S Gasparini, F Rueegg, D Stoehr, N Flor, PJ Vranesic, I Prezeau, L Pin, JP Thomsen, C Kuhn, R
Citation: S. Litschig et al., CPCCOEt, a noncompetitive metabotropic glutamate receptor 1 antagonist, inhibits receptor signaling without affecting glutamate binding, MOLEC PHARM, 55(3), 1999, pp. 453-461
Risultati: 1-25 | 26-28