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Results: 1-12 |
Results: 12
Getting the adrenaline going: Crystal structure of the adrenaline-synthesizing enzyme PNMT
Authors: Martin, JL Begun, J McLeish, MJ Caine, JM Grunewald, GL
Citation: Jl. Martin et al., Getting the adrenaline going: Crystal structure of the adrenaline-synthesizing enzyme PNMT, STRUCTURE, 9(10), 2001, pp. 977-985
Effects of a 3-alkyl-, 4-hydroxy- and/or 8-aromatic-substituent on the phenylethanolamine N-methyltransferase inhibitor potency and alpha(2)-adrenoceptor affinity of 2,3,4,5-tetrahydro-1H-2-benzazepines
Authors: Grunewald, GL Dahanukar, VH Criscione, KR
Citation: Gl. Grunewald et al., Effects of a 3-alkyl-, 4-hydroxy- and/or 8-aromatic-substituent on the phenylethanolamine N-methyltransferase inhibitor potency and alpha(2)-adrenoceptor affinity of 2,3,4,5-tetrahydro-1H-2-benzazepines, BIO MED CH, 9(8), 2001, pp. 1957-1965
Phenylethanolamine N-methyltransferase kinetics: Bovine versus recombinanthuman enzyme
Authors: Grunewald, GL McLeish, MJ Criscione, KR
Citation: Gl. Grunewald et al., Phenylethanolamine N-methyltransferase kinetics: Bovine versus recombinanthuman enzyme, BIOORG MED, 11(12), 2001, pp. 1579-1582
Synthesis and evaluation of 4-fluoro-8-substituted-2,3,4,5-tetrahydro-1H-2-benzazapines as selective inhibitors of phenylethanolamine N-methyltransferase versus the alpha(2)-adrenoceptor
Authors: Grunewald, GL Caldwell, TM Li, QF Criscione, KR
Citation: Gl. Grunewald et al., Synthesis and evaluation of 4-fluoro-8-substituted-2,3,4,5-tetrahydro-1H-2-benzazapines as selective inhibitors of phenylethanolamine N-methyltransferase versus the alpha(2)-adrenoceptor, J MED CHEM, 44(17), 2001, pp. 2849-2856
1,3-dimethyl-7-substituted-1,2,3,4-tetrahydroisoquinolines as probes for the binding orientation of tetrahydroisoquinoline at the active site of phenylethanolamine N-methyltransferase
Authors: Grunewald, GL Caldwell, TM Li, QF Criscione, KR
Citation: Gl. Grunewald et al., 1,3-dimethyl-7-substituted-1,2,3,4-tetrahydroisoquinolines as probes for the binding orientation of tetrahydroisoquinoline at the active site of phenylethanolamine N-methyltransferase, BIO MED CH, 7(5), 1999, pp. 869-880
Comparative molecular field analysis (CoMFA) models of phenylethanolamine N-methyltransferase (PNMT) and the alpha(2)-adrenoceptor: The development of new highly selective inhibitors of PNMT
Authors: Grunewald, GL Caldwell, TM Dahanukar, VH Jalluri, RK Criscione, KR
Citation: Gl. Grunewald et al., Comparative molecular field analysis (CoMFA) models of phenylethanolamine N-methyltransferase (PNMT) and the alpha(2)-adrenoceptor: The development of new highly selective inhibitors of PNMT, BIOORG MED, 9(3), 1999, pp. 481-486
The oxetane conformational lock of paclitaxel: Structural analysis of D-secopaclitaxel
Authors: Boge, TC Hepperle, M Vander Velde, DG Gunn, CW Grunewald, GL Georg, GI
Citation: Tc. Boge et al., The oxetane conformational lock of paclitaxel: Structural analysis of D-secopaclitaxel, BIOORG MED, 9(20), 1999, pp. 3041-3046
Enantiospecific synthesis of 3-fluoromethyl-, 3-hydroxymethyl-, and 3-chloromethyl-1,2,3,4-tetrahydroisoquinolines as selective inhibitors of phenylethanolamine N-methyltransferase versus the alpha(2)-adrenoceptor
Authors: Grunewald, GL Caldwell, TM Li, QF Dahanukar, VH McNeil, B Criscione, KR
Citation: Gl. Grunewald et al., Enantiospecific synthesis of 3-fluoromethyl-, 3-hydroxymethyl-, and 3-chloromethyl-1,2,3,4-tetrahydroisoquinolines as selective inhibitors of phenylethanolamine N-methyltransferase versus the alpha(2)-adrenoceptor, J MED CHEM, 42(21), 1999, pp. 4351-4361
Synthesis and biochemical evaluation of 3-fluoromethyl-1,2,3,4-tetrahydroisoquinolines as selective inhibitors of phenylethanolamine N-methyltransferase versus the alpha(2)-adrenoceptor
Authors: Grunewald, GL Caldwell, TM Li, QF Slavica, M Criscione, KR Borchardt, RT Wang, W
Citation: Gl. Grunewald et al., Synthesis and biochemical evaluation of 3-fluoromethyl-1,2,3,4-tetrahydroisoquinolines as selective inhibitors of phenylethanolamine N-methyltransferase versus the alpha(2)-adrenoceptor, J MED CHEM, 42(18), 1999, pp. 3588-3601
Synthesis and evaluation of 3-trifluoromethyl-7-substituted-1,2,3,4-tetrahydroisoquinolines as selective inhibitors of phenylethanolamine N-methyltransferase versus the alpha(2)-adrenoceptor
Authors: Grunewald, GL Caldwell, TM Li, QF Criscione, KR
Citation: Gl. Grunewald et al., Synthesis and evaluation of 3-trifluoromethyl-7-substituted-1,2,3,4-tetrahydroisoquinolines as selective inhibitors of phenylethanolamine N-methyltransferase versus the alpha(2)-adrenoceptor, J MED CHEM, 42(17), 1999, pp. 3315-3323
3,7-Disubstituted-1,2,3,4-tetrahydroisoquinolines display remarkable potency and selectivity as inhibitors of phenylethanolamine N-methyltransferase versus the alpha(2)-adrenoceptor
Authors: Grunewald, GL Dahanukar, VH Teoh, B Criscione, KR
Citation: Gl. Grunewald et al., 3,7-Disubstituted-1,2,3,4-tetrahydroisoquinolines display remarkable potency and selectivity as inhibitors of phenylethanolamine N-methyltransferase versus the alpha(2)-adrenoceptor, J MED CHEM, 42(11), 1999, pp. 1982-1990
Synthesis, biochemical evaluation, and classical and three-dimensional quantitative structure-activity relationship studies of 7-substituted-1,2,3,4-tetrahydroisoquinolines and their relative affinities toward phenylethanolamine N-methyltransferase and the alpha(2)-adrenoceptor
Authors: Grunewald, GL Dahanukar, VH Jalluri, RK Criscione, KR
Citation: Gl. Grunewald et al., Synthesis, biochemical evaluation, and classical and three-dimensional quantitative structure-activity relationship studies of 7-substituted-1,2,3,4-tetrahydroisoquinolines and their relative affinities toward phenylethanolamine N-methyltransferase and the alpha(2)-adrenoceptor, J MED CHEM, 42(1), 1999, pp. 118-134
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