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Results: 1-12 |
Results: 12
Synthesis and biological evaluation of 12,13-cyclopropyl and 12,13-cyclobutyl epothilones
Authors: Nicolaou, KC Namoto, K Li, J Ritzen, A Ulven, T Shoji, M Zaharevitz, D Gussio, R Sackett, DL Ward, RD Hensler, A Fojo, T Giannakakou, P
Citation: Kc. Nicolaou et al., Synthesis and biological evaluation of 12,13-cyclopropyl and 12,13-cyclobutyl epothilones, CHEMBIOCHEM, 2(1), 2001, pp. 69-75
Biochemical genetic analysis of indanocine resistance in human leukemia
Authors: Hua, XQH Genini, D Gussio, R Tawatao, R Shih, H Kipps, TJ Carson, DA Leoni, LM
Citation: Xqh. Hua et al., Biochemical genetic analysis of indanocine resistance in human leukemia, CANCER RES, 61(19), 2001, pp. 7248-7254
Mutants yield a pharmacophore model for the tubulin-paclitaxel binding site - Reply
Authors: Gussio, R Fojo, T Giannakakou, P
Citation: R. Gussio et al., Mutants yield a pharmacophore model for the tubulin-paclitaxel binding site - Reply, TRENDS PHAR, 21(9), 2000, pp. 323-324
Chemical synthesis and biological properties of pyridine epothilones
Authors: Nicolaou, KC Scarpelli, R Bollbuck, B Werschkun, B Pereira, MMA Wartmann, M Altmann, KH Zaharevitz, D Gussio, R Giannakakou, P
Citation: Kc. Nicolaou et al., Chemical synthesis and biological properties of pyridine epothilones, CHEM BIOL, 7(8), 2000, pp. 593-599
2-substituted paullones: CDK1/cyclin B-inhibiting property and in vitro antiproliferative activity
Authors: Kunick, C Schultz, C Lemcke, T Zaharevitz, DW Gussio, R Jalluri, RK Sausville, EA Leost, M Meijer, L
Citation: C. Kunick et al., 2-substituted paullones: CDK1/cyclin B-inhibiting property and in vitro antiproliferative activity, BIOORG MED, 10(6), 2000, pp. 567-569
Structure-based design modifications of the paullone molecular scaffold for cyclin-dependent kinase inhibition
Authors: Gussio, R Zaharevitz, DW McGrath, CF Pattabiraman, N Kellogg, GE Schultz, C Link, A Kunick, C Leost, M Meijer, L Sausville, EA
Citation: R. Gussio et al., Structure-based design modifications of the paullone molecular scaffold for cyclin-dependent kinase inhibition, ANTI-CAN DR, 15(1), 2000, pp. 53-66
A common pharmacophore for epothilone and taxanes: Molecular basis for drug resistance conferred by tubulin mutations in human cancer cells
Authors: Giannakakou, P Gussio, R Nogales, E Downing, KH Zaharevitz, D Bollbuck, B Poy, G Sackett, D Nicolaou, KC Fojo, T
Citation: P. Giannakakou et al., A common pharmacophore for epothilone and taxanes: Molecular basis for drug resistance conferred by tubulin mutations in human cancer cells, P NAS US, 97(6), 2000, pp. 2904-2909
Paullones are potent inhibitors of glycogen synthase kinase-3 beta and cyclin-dependent kinase 5/p25
Authors: Leost, M Schultz, C Link, A Wu, YZ Biernat, J Mandelkow, EM Bibb, JA Snyder, GL Greengard, P Zaharevitz, DW Gussio, R Senderowicz, AM Sausville, EA Kunick, C Meijer, L
Citation: M. Leost et al., Paullones are potent inhibitors of glycogen synthase kinase-3 beta and cyclin-dependent kinase 5/p25, EUR J BIOCH, 267(19), 2000, pp. 5983-5994
Discovery of novel HIV-1 reverse transcriptase inhibitors using a combination of 3D database searching and 3D QSAR
Authors: Zaharevitz, DW Gussio, R Wiegand, A Jalluri, R Pattabiraman, N Kellogg, GE Pallansch, LA Yang, SS Buckheit, RW
Citation: Dw. Zaharevitz et al., Discovery of novel HIV-1 reverse transcriptase inhibitors using a combination of 3D database searching and 3D QSAR, MED CHEM RE, 9(7-8), 1999, pp. 551-564
Cyclin-dependent kinases: Initial approaches to exploit a novel therapeutic target
Authors: Sausville, EA Zaharevitz, D Gussio, R Meijer, L Louarn-Leost, M Kunick, C Schultz, R Lahusen, T Headlee, D Stinson, S Arbuck, SG Senderowicz, A
Citation: Ea. Sausville et al., Cyclin-dependent kinases: Initial approaches to exploit a novel therapeutic target, PHARM THERA, 82(2-3), 1999, pp. 285-292
Paullones, a series of cyclin-dependent kinase inhibitors: Synthesis, evaluation of CDK1/cyclin B inhibition, and in vitro antitumor activity
Authors: Schultz, C Link, A Leost, M Zaharevitz, DW Gussio, R Sausville, EA Meijer, L Kunick, C
Citation: C. Schultz et al., Paullones, a series of cyclin-dependent kinase inhibitors: Synthesis, evaluation of CDK1/cyclin B inhibition, and in vitro antitumor activity, J MED CHEM, 42(15), 1999, pp. 2909-2919
Discovery and initial characterization of the paullones, a novel class of small-molecule inhibitors of cyclin-dependent kinases
Authors: Zaharevitz, DW Gussio, R Leost, M Senderowicz, AM Lahusen, T Kunick, C Meijer, L Sausville, EA
Citation: Dw. Zaharevitz et al., Discovery and initial characterization of the paullones, a novel class of small-molecule inhibitors of cyclin-dependent kinases, CANCER RES, 59(11), 1999, pp. 2566-2569
Risultati: 1-12 |