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Results: 1-16 |
Results: 16
A comparative molecular field analysis of cytochrome P450 2A5 and 2A6 inhibitors
Authors: Poso, A Gynther, J Juvonen, R
Citation: A. Poso et al., A comparative molecular field analysis of cytochrome P450 2A5 and 2A6 inhibitors, J COMPUT A, 15(3), 2001, pp. 195-202
Synthesis and in-vitro/in-vivo evaluation of orally administered entacapone prodrugs
Authors: Leppanen, J Savolainen, J Nevalainen, T Forsberg, M Huuskonen, J Taipale, H Gynther, J Mannisto, PT Jarvinen, T
Citation: J. Leppanen et al., Synthesis and in-vitro/in-vivo evaluation of orally administered entacapone prodrugs, J PHARM PHA, 53(11), 2001, pp. 1489-1498
Structural studies of acyl esters of entacapone
Authors: Leppanen, J Wegelius, E Nevalainen, T Jarvinen, T Gynther, J Huuskonen, J
Citation: J. Leppanen et al., Structural studies of acyl esters of entacapone, J MOL STRUC, 562(1-3), 2001, pp. 129-135
Synthesis of a water-soluble prodrug of entacapone
Authors: Leppanen, J Huuskonen, J Savolainen, J Nevalainen, T Taipale, H Vepsalainen, J Gynther, J Jarvinen, T
Citation: J. Leppanen et al., Synthesis of a water-soluble prodrug of entacapone, BIOORG MED, 10(17), 2000, pp. 1967-1969
Piperazinylalkyl prodrugs of naproxen improve in vitro skin permeation
Authors: Rautio, J Nevalainen, T Taipale, H Vepsalainen, J Gynther, J Laine, K Jarvinen, T
Citation: J. Rautio et al., Piperazinylalkyl prodrugs of naproxen improve in vitro skin permeation, EUR J PH SC, 11(2), 2000, pp. 157-163
Deformation behaviors of tolbutamide, hydroxypropyl-beta-cyclodextrin, andtheir dispersions
Authors: Suihko, E Poso, A Korhonen, O Gynther, J Ketolainen, J Paronen, P
Citation: E. Suihko et al., Deformation behaviors of tolbutamide, hydroxypropyl-beta-cyclodextrin, andtheir dispersions, PHARM RES, 17(8), 2000, pp. 942-948
Effects of aqueous solubility and dissolution characteristics on oral bioavailability of entacapone
Authors: Savolainen, J Forsberg, M Taipale, H Mannisto, PT Jarvinen, K Gynther, J Jarho, P Jarvinen, T
Citation: J. Savolainen et al., Effects of aqueous solubility and dissolution characteristics on oral bioavailability of entacapone, DRUG DEV R, 49(4), 2000, pp. 238-244
2(S)-Amino-3-[1H-imidazol-4(5)-yl]-propyl cyclohexylmethyl ether dihydrochloride and 2(S)-amino-3[1H-imidazol-4(5)-yl]propyl 4-bromobenzyl ether dihydrochloride
Authors: Kovalainen, JT Wegelius, E Christiaans, JAM Huuskonen, J Gynther, J
Citation: Jt. Kovalainen et al., 2(S)-Amino-3-[1H-imidazol-4(5)-yl]-propyl cyclohexylmethyl ether dihydrochloride and 2(S)-amino-3[1H-imidazol-4(5)-yl]propyl 4-bromobenzyl ether dihydrochloride, ACT CRYST C, 56, 2000, pp. E216-E217
Pronounced differences in inhibition potency of lactone and non-lactone compounds for mouse and human coumarin 7-hydroxylases (CYP2A5 and CYP2A6)
Authors: Juvonen, RO Gynther, J Pasanen, M Alhava, E Poso, A
Citation: Ro. Juvonen et al., Pronounced differences in inhibition potency of lactone and non-lactone compounds for mouse and human coumarin 7-hydroxylases (CYP2A5 and CYP2A6), XENOBIOTICA, 30(1), 2000, pp. 81-92
Synthesis and in vitro/in vivo evaluation of novel oral N-alkyl- and N,N-dialkyl-carbamate esters of entacapone
Authors: Savolainen, J Leppanen, J Forsberg, M Taipale, H Nevalainen, T Huuskonen, J Gynther, J Mannisto, PT Jarvinen, T
Citation: J. Savolainen et al., Synthesis and in vitro/in vivo evaluation of novel oral N-alkyl- and N,N-dialkyl-carbamate esters of entacapone, LIFE SCI, 67(2), 2000, pp. 205-216
Synthesis and in vitro evaluation of novel morpholinyl- and methylpiperazinylacyloxyalkyl prodrugs of 2-(6-methoxy-2-naphthyl)propionic acid (naproxen) for topical drug delivery
Authors: Rautio, J Nevalainen, T Taipale, H Vepsalainen, J Gynther, J Laine, K Jarvinen, T
Citation: J. Rautio et al., Synthesis and in vitro evaluation of novel morpholinyl- and methylpiperazinylacyloxyalkyl prodrugs of 2-(6-methoxy-2-naphthyl)propionic acid (naproxen) for topical drug delivery, J MED CHEM, 43(8), 2000, pp. 1489-1494
A proton relay process as the mechanism of activation of the histamine H-3-receptor determined by H-1 NMR and ab initio quantum mechanical calculations
Authors: Kovalainen, JT Christiaans, JAM Ropponen, R Poso, A Perakyla, M Vepsalainen, J Laatikainen, R Gynther, J
Citation: Jt. Kovalainen et al., A proton relay process as the mechanism of activation of the histamine H-3-receptor determined by H-1 NMR and ab initio quantum mechanical calculations, J AM CHEM S, 122(29), 2000, pp. 6989-6996
Synthesis and in vitro evaluation of aminoacyloxyalkyl esters of 2-(6-methoxy-2-naphthyl)propionic acid as novel naproxen prodrugs for dermal drug delivery
Authors: Rautio, J Nevalainen, T Taipale, H Vepsalainen, J Gynther, J Pedersen, T Jarvinen, T
Citation: J. Rautio et al., Synthesis and in vitro evaluation of aminoacyloxyalkyl esters of 2-(6-methoxy-2-naphthyl)propionic acid as novel naproxen prodrugs for dermal drug delivery, PHARM RES, 16(8), 1999, pp. 1172-1178
H-1 NMR study on putative intramolecular hydrogen bonding for histamine H-3-receptor agonists
Authors: Kovalainen, JT Christiaans, JAM Poso, A Vepsalainen, J Laatikainen, R Gynther, J
Citation: Jt. Kovalainen et al., H-1 NMR study on putative intramolecular hydrogen bonding for histamine H-3-receptor agonists, TETRAHEDR L, 40(12), 1999, pp. 2425-2428
Synthesis and in vitro pharmacology of a series of new chiral histamine H-3-receptor ligands: 2-(R and S)-amino-3-(1H-imidazol-4(5)-yl)propyl ether derivatives
Authors: Kovalainen, JT Christiaans, JAM Kotisaari, S Laitinen, JT Mannisto, PT Tuomisto, L Gynther, J
Citation: Jt. Kovalainen et al., Synthesis and in vitro pharmacology of a series of new chiral histamine H-3-receptor ligands: 2-(R and S)-amino-3-(1H-imidazol-4(5)-yl)propyl ether derivatives, J MED CHEM, 42(7), 1999, pp. 1193-1202
In vitro evaluation of acyloxyalkyl esters as dermal prodrugs of ketoprofen and naproxen
Authors: Rautio, J Taipale, H Gynther, J Vepsalainen, J Nevalainen, T Jarvinen, T
Citation: J. Rautio et al., In vitro evaluation of acyloxyalkyl esters as dermal prodrugs of ketoprofen and naproxen, J PHARM SCI, 87(12), 1998, pp. 1622-1628
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