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Results: 1-22 |
Results: 22
DESIGN AND SYNTHESIS OF N-ALKYLATED SACCHARINS AS SELECTIVE ALPHA-1A ADRENERGIC-RECEPTOR ANTAGONISTS
Authors: NERENBERG JB ERB JM THOMPSON WJ LEE HY GUARE JP MUNSON PM BERGMAN JM HUFF JR BROTEN TP CHANG RSL CHEN TB OMALLEY S SCHORN TW SCOTT AL
Citation: Jb. Nerenberg et al., DESIGN AND SYNTHESIS OF N-ALKYLATED SACCHARINS AS SELECTIVE ALPHA-1A ADRENERGIC-RECEPTOR ANTAGONISTS, Bioorganic & medicinal chemistry letters, 8(18), 1998, pp. 2467-2472
CRIXIVAN(R) - A POTENT INHIBITOR OF HIV-1 PROTEASE IN-VIVO
Authors: HUFF JR VACCA JP DORSEY BD EMINI EA CONDRA JH SCHLEIF WA MASSARI FE DEUTSCH PJ CHODAKEWITZ J KUO LC CHEN Z
Citation: Jr. Huff et al., CRIXIVAN(R) - A POTENT INHIBITOR OF HIV-1 PROTEASE IN-VIVO, The FASEB journal, 11(9), 1997, pp. 23-23
AROMATIC P-1 REPLACEMENTS FOR THE HIGHLY POTENT HIV-1 PROTEASE INHIBITOR CRIXIVAN(R)
Authors: COBURN CA YOUNG MB HUNGATE RW ISAACS RCA VACCA JP HUFF JR
Citation: Ca. Coburn et al., AROMATIC P-1 REPLACEMENTS FOR THE HIGHLY POTENT HIV-1 PROTEASE INHIBITOR CRIXIVAN(R), Bioorganic & medicinal chemistry letters, 6(16), 1996, pp. 1937-1940
NONPEPTIDAL P-2 LIGANDS FOR HIV PROTEASE INHIBITORS - STRUCTURE-BASEDDESIGN, SYNTHESIS, AND BIOLOGICAL EVALUATION
Authors: GHOSH AK KINCAID JF WALTERS DE CHEN Y CHAUDHURI NC THOMPSON WJ CULBERSON C FITZGERALD PMD LEE HY MCKEE SP MUNSON PM DUONG TT DARKE PL ZUGAY JA SCHLEIF WA AXEL MG LIN J HUFF JR
Citation: Ak. Ghosh et al., NONPEPTIDAL P-2 LIGANDS FOR HIV PROTEASE INHIBITORS - STRUCTURE-BASEDDESIGN, SYNTHESIS, AND BIOLOGICAL EVALUATION, Journal of medicinal chemistry, 39(17), 1996, pp. 3278-3290
SYNTHESIS AND EVALUATION OF PYRIDYL ANALOGS OF L-735,524 - POTENT HIV-1 PROTEASE INHIBITORS (VOL 4, PG 2769, 1994)
Authors: DORSEY BD MCDANIEL SL LEVIN RB VACCA JP DARKE PL ZUGAY JA EMINI EA SCHLEIF WA LIN JH CHEN IW HOLLOWAY MK ANDERSON PS HUFF JR
Citation: Bd. Dorsey et al., SYNTHESIS AND EVALUATION OF PYRIDYL ANALOGS OF L-735,524 - POTENT HIV-1 PROTEASE INHIBITORS (VOL 4, PG 2769, 1994), Bioorganic & medicinal chemistry letters, 5(7), 1995, pp. 773-773
2-HETEROCYCLIC INDOLE-3-SULFONES AS INHIBITORS OF HIV-1 REVERSE-TRANSCRIPTASE
Authors: YOUNG SD AMBLARD MC BRITCHER SF GREY VE TRAN LO LUMMA WC HUFF JR SCHLEIF WA EMINI EE OBRIEN JA PETTIBONE DJ
Citation: Sd. Young et al., 2-HETEROCYCLIC INDOLE-3-SULFONES AS INHIBITORS OF HIV-1 REVERSE-TRANSCRIPTASE, Bioorganic & medicinal chemistry letters, 5(5), 1995, pp. 491-496
CYCLOALKYLPIPERAZINES AS HIV-1 PROTEASE INHIBITORS - ENHANCED ORAL ABSORPTION
Authors: KIM BM EVANS BE GILBERT KF HANIFIN CM VACCA JP MICHELSON SR DARKE PL ZUGAY JA EMINI EA SCHLEIF W LIN JH CHEN IW VASTAG K ANDERSON PS HUFF JR
Citation: Bm. Kim et al., CYCLOALKYLPIPERAZINES AS HIV-1 PROTEASE INHIBITORS - ENHANCED ORAL ABSORPTION, Bioorganic & medicinal chemistry letters, 5(22), 1995, pp. 2707-2712
THIOPHENE DERIVATIVES AS EXTREMELY HIGH-AFFINITY P-3' LIGANDS FOR THEHYDROXYETHYLPIPERAZINE CLASS OF HIV-1 PROTEASE INHIBITORS
Authors: KIM BM GUARE JP VACCA JP MICHELSON SR DARKE PL ZUGAY JA EMINI EA SCHLEIF W LIN JH CHEN IW VASTAG K ANDERSON PS HUFF JR
Citation: Bm. Kim et al., THIOPHENE DERIVATIVES AS EXTREMELY HIGH-AFFINITY P-3' LIGANDS FOR THEHYDROXYETHYLPIPERAZINE CLASS OF HIV-1 PROTEASE INHIBITORS, Bioorganic & medicinal chemistry letters, 5(2), 1995, pp. 185-190
SUBSTITUTED ALKYLPYRIDINES AS P-3' LIGANDS FOR THE HYDROXYETHYLPIPERAZINE CLASS OF HIV-1 PROTEASE INHIBITORS - IMPROVED PHARMACOKINETIC PROFILES
Authors: KIM BM HANIFIN CM ZARTMAN CB VACCA JP MICHELSON SR LIN JH CHEN IW VASTAG K DARKE PL ZUGAY JA EMINI EA SCHLEIF W ANDERSON PS HUFF JR
Citation: Bm. Kim et al., SUBSTITUTED ALKYLPYRIDINES AS P-3' LIGANDS FOR THE HYDROXYETHYLPIPERAZINE CLASS OF HIV-1 PROTEASE INHIBITORS - IMPROVED PHARMACOKINETIC PROFILES, Bioorganic & medicinal chemistry letters, 5(19), 1995, pp. 2239-2244
CYCLIC SULFONE-3-CARBOXAMIDES AS NOVEL P-2-LIGANDS FOR RO-31-8959 BASED HIV-1 PROTEASE INHIBITORS
Authors: GHOSH AK THOMPSON WJ MUNSON PM LIU WM HUFF JR
Citation: Ak. Ghosh et al., CYCLIC SULFONE-3-CARBOXAMIDES AS NOVEL P-2-LIGANDS FOR RO-31-8959 BASED HIV-1 PROTEASE INHIBITORS, Bioorganic & medicinal chemistry letters, 5(1), 1995, pp. 83-88
L-743,726 (DMP-266) - A NOVEL, HIGHLY POTENT NONNUCLEOSIDE INHIBITOR OF THE HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 REVERSE-TRANSCRIPTASE
Authors: YOUNG SD BRITCHER SF TRAN LO PAYNE LS LUMMA WC LYLE TA HUFF JR ANDERSON PS OLSEN DB CARROLL SS PETTIBONE DJ OBRIEN JA BALL RG BALANI SK LIN JH CHEN IW SCHLEIF WA SARDANA VV LONG WJ BYRNES VW EMINI EA
Citation: Sd. Young et al., L-743,726 (DMP-266) - A NOVEL, HIGHLY POTENT NONNUCLEOSIDE INHIBITOR OF THE HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 REVERSE-TRANSCRIPTASE, Antimicrobial agents and chemotherapy, 39(12), 1995, pp. 2602-2605
CONFORMATIONALLY CONSTRAINED HIV-1 PROTEASE INHIBITORS
Authors: VACCA JP FITZGERALD PMD HOLLOWAY MK HUNGATE RW STARBUCK KE CHEN LJ DARKE PL ANDERSON PS HUFF JR
Citation: Jp. Vacca et al., CONFORMATIONALLY CONSTRAINED HIV-1 PROTEASE INHIBITORS, Bioorganic & medicinal chemistry letters, 4(3), 1994, pp. 499-504
SYNTHESIS AND EVALUATION OF PYRIDYL ANALOGS OF L-735,524 - POTENT HIV-1 PROTEASE INHIBITORS
Authors: DORSEY BD MCDANIEL SL LEVIN RB VACCA JP DARKE PL ZUGAY JA EMINI EA SCHLEIF WA LIN JH CHEN IW HOLLOWAY MK ANDERSON PS HUFF JR
Citation: Bd. Dorsey et al., SYNTHESIS AND EVALUATION OF PYRIDYL ANALOGS OF L-735,524 - POTENT HIV-1 PROTEASE INHIBITORS, Bioorganic & medicinal chemistry letters, 4(23), 1994, pp. 2769-2774
A NEW HYDROXYETHYLAMINE CLASS OF HIV-1 PROTEASE INHIBITORS WITH HIGH ANTIVIRAL POTENCY AND ORAL BIOAVAILABILITY
Authors: KIM BM VACCA JP GUARE JP HANIFIN CM MICHELSON SR DARKE PL ZUGAY JA EMINI EA SCHLEIF W LIN JH CHEN IW VASTAG K OSTOVIC D ANDERSON PS HUFF JR
Citation: Bm. Kim et al., A NEW HYDROXYETHYLAMINE CLASS OF HIV-1 PROTEASE INHIBITORS WITH HIGH ANTIVIRAL POTENCY AND ORAL BIOAVAILABILITY, Bioorganic & medicinal chemistry letters, 4(19), 1994, pp. 2273-2278
NOVEL CONFORMATIONALLY CONSTRAINED HIV-1 PROTEASE INHIBITORS - RATIONAL DESIGN, ENZYME-INHIBITION, AND X-RAY STRUCTURE OF AN ENZYME-INHIBITOR COMPLEX
Authors: KIM BM VACCA JP FITZGERALD PMD DARKE PL HOLLOWAY MK GUARE JP HANIFIN CM ARFORDBICKERSTAFF DJ ZUGAY JA WAI JM ANDERSON PS HUFF JR
Citation: Bm. Kim et al., NOVEL CONFORMATIONALLY CONSTRAINED HIV-1 PROTEASE INHIBITORS - RATIONAL DESIGN, ENZYME-INHIBITION, AND X-RAY STRUCTURE OF AN ENZYME-INHIBITOR COMPLEX, Bioorganic & medicinal chemistry letters, 4(18), 1994, pp. 2199-2204
THE DESIGN AND SYNTHESIS OF ORALLY BIOAVAILABLE HIV-1 PROTEASE INHIBITORS
Authors: HUFF JR VACCA JP DORSEY BD THOMPSON WJ GHOSH AK HUNGATE RW LEE HY DARKE PL EMINI EA SCHLEIF WA LIN JH CHEN IW HOLLOWAY MK ANDERSON PS
Citation: Jr. Huff et al., THE DESIGN AND SYNTHESIS OF ORALLY BIOAVAILABLE HIV-1 PROTEASE INHIBITORS, Journal of cellular biochemistry, 1994, pp. 130-130
L-735,524 - AN ORALLY BIOAVAILABLE HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 PROTEASE INHIBITOR
Authors: VACCA JP DORSEY BD SCHLEIF WA LEVIN RB MCDANIEL SL DARKE PL ZUGAY J QUINTERO JC BLAHY OM ROTH E SARDANA VV SCHLABACH AJ GRAHAM PI CONDRA JH GOTLIB L HOLLOWAY MK LIN J CHEN IW VASTAG K OSTOVIC D ANDERSON PS EMINI EA HUFF JR
Citation: Jp. Vacca et al., L-735,524 - AN ORALLY BIOAVAILABLE HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 PROTEASE INHIBITOR, Proceedings of the National Academy of Sciences of the United Statesof America, 91(9), 1994, pp. 4096-4100
THE DEVELOPMENT OF CYCLIC SULFOLANES AS NOVEL AND HIGH-AFFINITY P(2) LIGANDS FOR HIV-1 PROTEASE INHIBITORS
Authors: GHOSH AK LEE HY THOMPSON WJ CULBERSON C HOLLOWAY MK MCKEE SP MUNSON PM DUONG TT SMITH AM DARKE PL ZUGAY JA EMINI EA SCHLEIF WA HUFF JR ANDERSON PS
Citation: Ak. Ghosh et al., THE DEVELOPMENT OF CYCLIC SULFOLANES AS NOVEL AND HIGH-AFFINITY P(2) LIGANDS FOR HIV-1 PROTEASE INHIBITORS, Journal of medicinal chemistry, 37(8), 1994, pp. 1177-1188
L-735,524 - THE DESIGN OF A POTENT AND ORALLY BIOAVAILABLE HIV PROTEASE INHIBITOR
Authors: DORSEY BD LEVIN RB MCDANIEL SL VACCA JP GUARE JP DARKE PL ZUGAY JA EMINI EA SCHLEIF WA QUINTERO JC LIN JH CHEN IW HOLLOWAY MK FITZGERALD PMD AXEL MG OSTOVIC D ANDERSON PS HUFF JR
Citation: Bd. Dorsey et al., L-735,524 - THE DESIGN OF A POTENT AND ORALLY BIOAVAILABLE HIV PROTEASE INHIBITOR, Journal of medicinal chemistry, 37(21), 1994, pp. 3443-3451
STRUCTURE-BASED DESIGN OF HIV-1 PROTEASE INHIBITORS - REPLACEMENT OF 2 AMIDES AND A 10-PI-AROMATIC SYSTEM BY A FUSED BIS-TETRAHYDROFURAN
Authors: GHOSH AK THOMPSON WJ FITZGERALD PMD CULBERSON JC AXEL MG MCKEE SP HUFF JR ANDERSON PS
Citation: Ak. Ghosh et al., STRUCTURE-BASED DESIGN OF HIV-1 PROTEASE INHIBITORS - REPLACEMENT OF 2 AMIDES AND A 10-PI-AROMATIC SYSTEM BY A FUSED BIS-TETRAHYDROFURAN, Journal of medicinal chemistry, 37(16), 1994, pp. 2506-2508
SYNTHESIS OF A SERIES OF ORO-4-CYCLOPROPYL-3,4-DIHYDROQUINAZOLIN-2(1H)-ONES AS NOVEL NONNUCLEOSIDE HIV-1 REVERSE-TRANSCRIPTASE INHIBITORS
Authors: TUCKER TJ LYLE TA WISCOUNT CM BRITCHER SF YOUNG SD SANDERS WM LUMMA WC GOLDMAN ME OBRIEN JA BALL RG HOMNICK CF SCHLEIF WA EMINI EA HUFF JR ANDERSON PS
Citation: Tj. Tucker et al., SYNTHESIS OF A SERIES OF ORO-4-CYCLOPROPYL-3,4-DIHYDROQUINAZOLIN-2(1H)-ONES AS NOVEL NONNUCLEOSIDE HIV-1 REVERSE-TRANSCRIPTASE INHIBITORS, Journal of medicinal chemistry, 37(15), 1994, pp. 2437-2444
POTENT HIV PROTEASE INHIBITORS - THE DEVELOPMENT OF TETRAHYDROFURANYLGLYCINES AS NOVEL P(2)-LIGANDS AND PYRAZINE AMIDES AS P(3)-LIGANDS
Authors: GHOSH AK THOMPSON WJ HOLLOWAY MK MCKEE SP DUONG TT LEE HY MUNSON PM SMITH AM WAI JM DARKE PL ZUGAY JA EMINI EA SCHLEIF WA HUFF JR ANDERSON PS
Citation: Ak. Ghosh et al., POTENT HIV PROTEASE INHIBITORS - THE DEVELOPMENT OF TETRAHYDROFURANYLGLYCINES AS NOVEL P(2)-LIGANDS AND PYRAZINE AMIDES AS P(3)-LIGANDS, Journal of medicinal chemistry, 36(16), 1993, pp. 2300-2310
Risultati: 1-22 |