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Results: 1-13 |
Results: 13
NONPEPTIDE FIBRINOGEN RECEPTOR ANTAGONISTS - 3 - THE SYNTHESIS OF [H-3]L-767,685 AND [H-3]L-767,679
Authors: HAMILL TG HUTCHINSON JH HARTMAN GD BURNS HD
Citation: Tg. Hamill et al., NONPEPTIDE FIBRINOGEN RECEPTOR ANTAGONISTS - 3 - THE SYNTHESIS OF [H-3]L-767,685 AND [H-3]L-767,679, Journal of labelled compounds & radiopharmaceuticals, 41(7), 1998, pp. 677-680
NONPEPTIDE GLYCOPROTEIN IIB IIIA INHIBITORS .18. INDOLE ALPHA-SULFONAMIDE ACIDS ARE POTENT INHIBITORS OF PLATELET-AGGREGATION/
Authors: BRASHEAR KM COOK JJ BEDNAR B BEDNAR RA GOULD RJ HALCZENKO W HOLAHAN MA LYNCH RJ HARTMAN GD HUTCHINSON JH
Citation: Km. Brashear et al., NONPEPTIDE GLYCOPROTEIN IIB IIIA INHIBITORS .18. INDOLE ALPHA-SULFONAMIDE ACIDS ARE POTENT INHIBITORS OF PLATELET-AGGREGATION/, Bioorganic & medicinal chemistry letters, 7(21), 1997, pp. 2793-2798
IN-VITRO AND IN-VIVO EVALUATIONS OF THE METABOLISM, PHARMACOKINETICS,AND BIOAVAILABILITY OF ESTER PRODRUGS OF L-767,679, A POTENT FIBRINOGEN RECEPTOR ANTAGONIST - AN APPROACH FOR THE SELECTION OF A PRODRUG CANDIDATE
Authors: PRUEKSARITANONT T GORHAM LM BRESLIN MJ HUTCHINSON JH HARTMAN GD VYAS KP BAILLIE TA
Citation: T. Prueksaritanont et al., IN-VITRO AND IN-VIVO EVALUATIONS OF THE METABOLISM, PHARMACOKINETICS,AND BIOAVAILABILITY OF ESTER PRODRUGS OF L-767,679, A POTENT FIBRINOGEN RECEPTOR ANTAGONIST - AN APPROACH FOR THE SELECTION OF A PRODRUG CANDIDATE, Drug metabolism and disposition, 25(8), 1997, pp. 978-984
NONPEPTIDE GLYCOPROTEIN IIB IIIA ANTAGONISTS .2. DESIGN AND IN-VIVO EVALUATION OF 3,4-DIHYDRO-1(1H)-ISOQUINOLINONE-BASED ANTAGONISTS AND ETHYL-ESTER PRODRUGS/
Authors: HUTCHINSON JH COOK JJ BRASHEAR KM BRESLIN MJ GLASS JD GOULD RJ HALCZENKO W HOLAHAN MA LYNCH RJ SITKO GR STRANIERI MT HARTMAN GD
Citation: Jh. Hutchinson et al., NONPEPTIDE GLYCOPROTEIN IIB IIIA ANTAGONISTS .2. DESIGN AND IN-VIVO EVALUATION OF 3,4-DIHYDRO-1(1H)-ISOQUINOLINONE-BASED ANTAGONISTS AND ETHYL-ESTER PRODRUGS/, Journal of medicinal chemistry, 39(23), 1996, pp. 4583-4591
THIOPYRANOL[2,3,4-C,D] INDOLES AS INHIBITORS OF 5-LIPOXYGENASE, 5-LIPOXYGENASE-ACTIVATING PROTEIN, AND LEUKOTRIENE C-4 SYNTHASE
Authors: HUTCHINSON JH CHARLESON S EVANS JF FALGUEYRET JP HOOGSTEEN K JONES TR KARGMAN S MACDONALD D MCFARLANE CS NICHOLSON DW PIECHUTA H RIENDEAU D SCHEIGETZ J THERIEN M GIRARD Y
Citation: Jh. Hutchinson et al., THIOPYRANOL[2,3,4-C,D] INDOLES AS INHIBITORS OF 5-LIPOXYGENASE, 5-LIPOXYGENASE-ACTIVATING PROTEIN, AND LEUKOTRIENE C-4 SYNTHASE, Journal of medicinal chemistry, 38(22), 1995, pp. 4538-4547
CHARACTERIZATION OF THE ARACHIDONATE AND ATP BINDING-SITES OF HUMAN 5-LIPOXYGENASE USING PHOTOAFFINITY-LABELING AND ENZYME IMMOBILIZATION
Authors: FALGUEYRET JP DENIS D MACDONALD D HUTCHINSON JH RIENDEAU D
Citation: Jp. Falgueyret et al., CHARACTERIZATION OF THE ARACHIDONATE AND ATP BINDING-SITES OF HUMAN 5-LIPOXYGENASE USING PHOTOAFFINITY-LABELING AND ENZYME IMMOBILIZATION, Biochemistry, 34(41), 1995, pp. 13603-13611
THIOPYRANO[2,3,4-CD]INDOLES AS 5-LIPOXYGENASE INHIBITORS - SYNTHESIS,BIOLOGICAL PROFILE, AND RESOLUTION OF RO-1H-THIOPYRANO[2,3,4-CD]INDOL-YL]ETHOXY]BUTANOIC ACID
Authors: HUTCHINSON JH RIENDEAU D BRIDEAU C CHAN C FALGUEYRET JP GUAY J JONES TR LEPINE C MACDONALD D MCFARLANE CS PIECHUTA H SCHEIGETZ J TAGARI P THERIEN M GIRARD Y
Citation: Jh. Hutchinson et al., THIOPYRANO[2,3,4-CD]INDOLES AS 5-LIPOXYGENASE INHIBITORS - SYNTHESIS,BIOLOGICAL PROFILE, AND RESOLUTION OF RO-1H-THIOPYRANO[2,3,4-CD]INDOL-YL]ETHOXY]BUTANOIC ACID, Journal of medicinal chemistry, 37(8), 1994, pp. 1153-1164
NAPHTHALENIC LIGNAN LACTONES AS SELECTIVE, NONREDOX 5-LIPOXYGENASE INHIBITORS - SYNTHESIS AND BIOLOGICAL-ACTIVITY OF (METHOXYALKYL)THIAZOLEAND METHOXYTETRAHYDROPYRAN HYBRIDS
Authors: DUCHARME Y BRIDEAU C DUBE D CHAN CC FALGUEYRET JP GILLARD JW GUAY J HUTCHINSON JH MCFARLANE CS RIENDEAU D SCHEIGETZ J GIRARD Y
Citation: Y. Ducharme et al., NAPHTHALENIC LIGNAN LACTONES AS SELECTIVE, NONREDOX 5-LIPOXYGENASE INHIBITORS - SYNTHESIS AND BIOLOGICAL-ACTIVITY OF (METHOXYALKYL)THIAZOLEAND METHOXYTETRAHYDROPYRAN HYBRIDS, Journal of medicinal chemistry, 37(4), 1994, pp. 512-518
DISCOVERY OF INHIBITORS OF THE 5-LIPOXYGENASE ACTIVATING PROTEIN (FLAP)
Authors: YOUNG RN GILLARD JW HUTCHINSON JH LEGER S PRASIT P
Citation: Rn. Young et al., DISCOVERY OF INHIBITORS OF THE 5-LIPOXYGENASE ACTIVATING PROTEIN (FLAP), Journal of lipid mediators, 6(1-3), 1993, pp. 233-238
A NEW CLASS OF LEUKOTRIENE BIOSYNTHESIS INHIBITOR - THE DEVELOPMENT OF MK-0591
Authors: PRASIT P BELLEY M BLOUIN M BRIDEAU C CHAN C CHARLESON S EVANS JF FRENETTE R GAUTHIER JY GUAY J GILLARD JW GRIMM E FORDHUTCHINSON AW HUTCHINSON JH FORTIN R JONES TR MANCINI J LEGER S MCFARLANE CS PIECHUTA H RIENDEAU D ROY P TAGARI P VICKERS PJ YOUNG RN ZAMBONI R
Citation: P. Prasit et al., A NEW CLASS OF LEUKOTRIENE BIOSYNTHESIS INHIBITOR - THE DEVELOPMENT OF MK-0591, Journal of lipid mediators, 6(1-3), 1993, pp. 239-244
INHIBITION OF SYNOVIAL-LTB(4) PRODUCTION BY A SPECIFIC LEUKOTRIENE BIOSYNTHESIS INHIBITOR, MK-0591, IN A RABBIT MODEL OF JOINT INFLAMMATION
Authors: BRIDEAU C CHAN CC GUEVREMONT D HUTCHINSON JH MCDONNELL J MOORE V
Citation: C. Brideau et al., INHIBITION OF SYNOVIAL-LTB(4) PRODUCTION BY A SPECIFIC LEUKOTRIENE BIOSYNTHESIS INHIBITOR, MK-0591, IN A RABBIT MODEL OF JOINT INFLAMMATION, Drug development research, 29(3), 1993, pp. 188-194
SUBSTITUTED THIOPYRANO[2,3,4-C,D]INDOLES AS POTENT, SELECTIVE, AND ORALLY-ACTIVE INHIBITORS OF 5-LIPOXYGENASE - SYNTHESIS AND BIOLOGICAL EVALUATION OF L-691,816
Authors: HUTCHINSON JH RIENDEAU D BRIDEAU C CHAN C DELORME D DENIS D FALGUEYRET JP FORTIN R GUAY J HAMEL P JONES TR MACDONALD D MCFARLANE CS PIECHUTA H SCHEIGETZ J TAGARI P THERIEN M GIRARD Y
Citation: Jh. Hutchinson et al., SUBSTITUTED THIOPYRANO[2,3,4-C,D]INDOLES AS POTENT, SELECTIVE, AND ORALLY-ACTIVE INHIBITORS OF 5-LIPOXYGENASE - SYNTHESIS AND BIOLOGICAL EVALUATION OF L-691,816, Journal of medicinal chemistry, 36(19), 1993, pp. 2771-2787
THE ACYLOIN REACTION USING TETHERED DIESTERS
Authors: DAYNARD TS EBY PS HUTCHINSON JH
Citation: Ts. Daynard et al., THE ACYLOIN REACTION USING TETHERED DIESTERS, Canadian journal of chemistry, 71(7), 1993, pp. 1022-1028
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