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Results: 1-25 | 26-50 | 51-55
Results: 1-25/55
A novel palladium-mediated coupling approach to 2,3-disubstituted benzo[b]thiophenes and its application to the synthesis of tubulin binding agents
Authors: Flynn, BL Verdier-Pinard, P Hamel, E
Citation: Bl. Flynn et al., A novel palladium-mediated coupling approach to 2,3-disubstituted benzo[b]thiophenes and its application to the synthesis of tubulin binding agents, ORG LETT, 3(5), 2001, pp. 651-654
Antitumor agents. Part 204: Synthesis and biological evaluation of substituted 2-aryl quinazolinones
Authors: Xia, Y Yang, ZY Hour, MJ Kuo, SC Xia, P Bastow, KF Nakanishi, Y Nampoothiri, P Hackl, T Hamel, E Lee, KH
Citation: Y. Xia et al., Antitumor agents. Part 204: Synthesis and biological evaluation of substituted 2-aryl quinazolinones, BIOORG MED, 11(9), 2001, pp. 1193-1196
The synthesis and tubulin binding activity of thiophene-based analogues ofcombretastatin A-4
Authors: Flynn, BL Flynn, GP Hamel, E Jung, MK
Citation: Bl. Flynn et al., The synthesis and tubulin binding activity of thiophene-based analogues ofcombretastatin A-4, BIOORG MED, 11(17), 2001, pp. 2341-2343
5-HT7 receptor mRNA expression in human trigeminal ganglia
Authors: Terron, JA Bouchelet, I Hamel, E
Citation: Ja. Terron et al., 5-HT7 receptor mRNA expression in human trigeminal ganglia, NEUROSCI L, 302(1), 2001, pp. 9-12
The effects of chelidonine on tubulin polymerisation, cell cycle progression and selected signal transmission pathways
Authors: Panzer, A Joubert, AM Bianchi, PC Hamel, E Seegers, JC
Citation: A. Panzer et al., The effects of chelidonine on tubulin polymerisation, cell cycle progression and selected signal transmission pathways, EUR J CELL, 80(1), 2001, pp. 111-118
Dolastatin 11, a marine depsipeptide, arrests cells at cytokinesis and induces hyperpolymerization of purified actin
Authors: Bai, RL Verdier-Pinard, P Gangwar, S Stessman, CC McClure, KJ Sausville, EA Pettit, GR Bates, RB Hamel, E
Citation: Rl. Bai et al., Dolastatin 11, a marine depsipeptide, arrests cells at cytokinesis and induces hyperpolymerization of purified actin, MOLEC PHARM, 59(3), 2001, pp. 462-469
Design, synthesis, and biological evaluation of a series of lavendustin A analogues that inhibit EGFR and Syk tyrosine kinases, as well as tubulin polymerization
Authors: Mu, FR Coffing, SL Riese, DJ Geahlen, RL Verdier-Pinard, P Hamel, E Johnson, J Cushman, M
Citation: Fr. Mu et al., Design, synthesis, and biological evaluation of a series of lavendustin A analogues that inhibit EGFR and Syk tyrosine kinases, as well as tubulin polymerization, J MED CHEM, 44(3), 2001, pp. 441-452
Antitumor agents. 211. Fluorinated 2-phenyl-4-quinolone derivatives as antimitotic antitumor agents
Authors: Xia, Y Yang, ZY Xia, P Hackl, T Hamel, E Mauger, A Wu, JH Lee, KH
Citation: Y. Xia et al., Antitumor agents. 211. Fluorinated 2-phenyl-4-quinolone derivatives as antimitotic antitumor agents, J MED CHEM, 44(23), 2001, pp. 3932-3936
Thrombolysis or heparin therapy in massive pulmonary embolism with right ventricular dilation - Results from a 128-patient monocenter registry
Authors: Hamel, E Pacouret, G Vincentelli, D Forissier, JF Peycher, P Pottier, JM Charbonnier, B
Citation: E. Hamel et al., Thrombolysis or heparin therapy in massive pulmonary embolism with right ventricular dilation - Results from a 128-patient monocenter registry, CHEST, 120(1), 2001, pp. 120-125
Sumatriptan elicits both constriction and dilation in human and bovine brain intracortical arterioles
Authors: Elhusseiny, A Hamel, E
Citation: A. Elhusseiny et E. Hamel, Sumatriptan elicits both constriction and dilation in human and bovine brain intracortical arterioles, BR J PHARM, 132(1), 2001, pp. 55-62
Indanocine, a microtubule-binding indanone and a selective inducer of apoptosis in multidrug-resistant cancer cells
Authors: Leoni, LM Hamel, E Genini, D Shih, HC Carrera, CJ Cottam, HB Carson, DA
Citation: Lm. Leoni et al., Indanocine, a microtubule-binding indanone and a selective inducer of apoptosis in multidrug-resistant cancer cells, J NAT CANC, 92(3), 2000, pp. 217-224
Synthesis and biological evaluation of aryl azide derivatives of combretastatin A-4 as molecular probes for tubulin
Authors: Pinney, KG Mejia, MP Villalobos, VM Rosenquist, BE Pettit, GR Verdier-Pinard, P Hamel, E
Citation: Kg. Pinney et al., Synthesis and biological evaluation of aryl azide derivatives of combretastatin A-4 as molecular probes for tubulin, BIO MED CH, 8(10), 2000, pp. 2417-2425
Basal forebrain nitric oxide synthase (NOS)-containing neurons project to microvessels and NOS neurons in the rat neocortex: cellular basis for cortical blood flow regulation
Authors: Tong, XK Hamel, E
Citation: Xk. Tong et E. Hamel, Basal forebrain nitric oxide synthase (NOS)-containing neurons project to microvessels and NOS neurons in the rat neocortex: cellular basis for cortical blood flow regulation, EUR J NEURO, 12(8), 2000, pp. 2769-2780
Serotonin 5-HT7 receptors mediate relaxation of porcine pial veins
Authors: Ishine, T Bouchelet, I Hamel, E Lee, TJF
Citation: T. Ishine et al., Serotonin 5-HT7 receptors mediate relaxation of porcine pial veins, AM J P-HEAR, 278(3), 2000, pp. H907-H912
Ukrain (TM) a semisynthetic Chelidonium majus alkaloid derivative, acts byinhibition of tubulin polymerization in normal and malignant cell lines
Authors: Panzer, A Hamel, E Joubert, AM Bianchi, PC Seegers, JC
Citation: A. Panzer et al., Ukrain (TM) a semisynthetic Chelidonium majus alkaloid derivative, acts byinhibition of tubulin polymerization in normal and malignant cell lines, CANCER LETT, 160(2), 2000, pp. 149-157
Convergent synthesis and preliminary biological evaluation of (+/-)-B-norrhazinal
Authors: Banwell, M Edwards, A Smith, J Hamel, E Verdier-Pinard, P
Citation: M. Banwell et al., Convergent synthesis and preliminary biological evaluation of (+/-)-B-norrhazinal, J CHEM S P1, 10, 2000, pp. 1497-1499
Muscarinic-but not nicotinic-acetylcholine receptors mediate a nitric oxide-dependent dilation in brain cortical arterioles: A possible role for the M5 receptor subtype
Authors: Elhusseiny, A Hamel, E
Citation: A. Elhusseiny et E. Hamel, Muscarinic-but not nicotinic-acetylcholine receptors mediate a nitric oxide-dependent dilation in brain cortical arterioles: A possible role for the M5 receptor subtype, J CEREBR B, 20(2), 2000, pp. 298-305
Antineoplastic agents 442. Synthesis and biological activities of dioxostatin
Authors: Pettit, GR Lippert, JW Boyd, MR Verdier-Pinard, P Hamel, E
Citation: Gr. Pettit et al., Antineoplastic agents 442. Synthesis and biological activities of dioxostatin, ANTI-CAN DR, 15(5), 2000, pp. 361-371
Antineoplastic agents 440. Asymmetric synthesis and evaluation of the combretastatin A-1 SAR probes (1S,2S)- and (1R,2R)-1,2-dihydroxy-1-(2 ',3 '-dihydroxy-4 '-methoxyphenyl)-2-(3 '',4 '',5 ''-trimethoxyphenyl)-ethane
Authors: Pettit, GR Lippert, JW Herald, DL Hamel, E Pettit, RK
Citation: Gr. Pettit et al., Antineoplastic agents 440. Asymmetric synthesis and evaluation of the combretastatin A-1 SAR probes (1S,2S)- and (1R,2R)-1,2-dihydroxy-1-(2 ',3 '-dihydroxy-4 '-methoxyphenyl)-2-(3 '',4 '',5 ''-trimethoxyphenyl)-ethane, J NAT PROD, 63(7), 2000, pp. 969-974
A steroid derivative with paclitaxel-like effects on tubulin polymerization
Authors: Verdier-Pinard, P Wang, ZQ Mohanakrishnan, AK Cushman, M Hamel, E
Citation: P. Verdier-pinard et al., A steroid derivative with paclitaxel-like effects on tubulin polymerization, MOLEC PHARM, 57(3), 2000, pp. 568-575
Sustained intracellular retention of dolastatin 10 causes its potent antimitotic activity
Authors: Verdier-Pinard, P Kepler, JA Pettit, GR Hamel, E
Citation: P. Verdier-pinard et al., Sustained intracellular retention of dolastatin 10 causes its potent antimitotic activity, MOLEC PHARM, 57(1), 2000, pp. 180-187
Preparation of new anti-tubulin ligands through a dual-mode, addition-elimination reaction to a bromo-substituted alpha,beta-unsaturated sulfoxide
Authors: Chen, Z Mocharla, VP Farmer, JM Pettit, GR Hamel, E Pinney, KG
Citation: Z. Chen et al., Preparation of new anti-tubulin ligands through a dual-mode, addition-elimination reaction to a bromo-substituted alpha,beta-unsaturated sulfoxide, J ORG CHEM, 65(25), 2000, pp. 8811-8815
6-alkylamino- and 2,3-dihydro-3 '-methoxy-2-phenyl-4-quinazolinones and related compounds: Their synthesis, cytotoxicity, and inhibition of tubulin polymerization
Authors: Hour, MJ Huang, LJ Kuo, SC Xia, Y Bastow, K Nakanishi, Y Hamel, E Lee, KH
Citation: Mj. Hour et al., 6-alkylamino- and 2,3-dihydro-3 '-methoxy-2-phenyl-4-quinazolinones and related compounds: Their synthesis, cytotoxicity, and inhibition of tubulin polymerization, J MED CHEM, 43(23), 2000, pp. 4479-4487
Antitumor agents. 199. Three-dimensional quantitative structure-activity relationship study of the colchicine binding site ligands using comparative molecular field analysis
Authors: Zhang, SX Feng, J Kuo, SC Brossi, A Hamel, E Tropsha, A Li, KH
Citation: Sx. Zhang et al., Antitumor agents. 199. Three-dimensional quantitative structure-activity relationship study of the colchicine binding site ligands using comparative molecular field analysis, J MED CHEM, 43(2), 2000, pp. 167-176
Antineoplastic agents. 443. Synthesis of the cancer cell growth inhibitor hydroxyphenstatin and its sodium diphosphate prodrug
Authors: Pettit, GR Grealish, MP Herald, DL Boyd, MR Hamel, E Pettit, RK
Citation: Gr. Pettit et al., Antineoplastic agents. 443. Synthesis of the cancer cell growth inhibitor hydroxyphenstatin and its sodium diphosphate prodrug, J MED CHEM, 43(14), 2000, pp. 2731-2737
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