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Results: 1-25 | 26-30
Results: 1-25/30
Effect of phytoestrogen and antioxidant supplementation on oxidative DNA damage assessed using the comet assay
Authors: Sierens, J Hartley, JA Campbell, MJ Leathem, AJC Woodside, JV
Citation: J. Sierens et al., Effect of phytoestrogen and antioxidant supplementation on oxidative DNA damage assessed using the comet assay, MUT R-DNA R, 485(2), 2001, pp. 169-176
Efficient synthesis of (+/-)-seco-cyclopropaneindoline analogs of CC-1065
Authors: Jennings, SA Toth, JL Roller, SG Brooks, N O'Hare, C Kiakos, K Hartley, JA Burke, PJ Lee, M
Citation: Sa. Jennings et al., Efficient synthesis of (+/-)-seco-cyclopropaneindoline analogs of CC-1065, HETEROCYC C, 7(1), 2001, pp. 7-16
Measurement of covalent drug-DNA interactions at the nucleotide level in cells at pharmacologically relevant doses
Authors: McGurk, CJ McHugh, PJ Tilby, MJ Grimaldi, KA Hartley, JA
Citation: Cj. Mcgurk et al., Measurement of covalent drug-DNA interactions at the nucleotide level in cells at pharmacologically relevant doses, METH ENZYM, 340, 2001, pp. 358-376
Transcriptional regulation of topoisomerase II alpha at confluence and pharmacological modulation of expression by bis-benzimidazole drugs
Authors: Tolner, B Hartley, JA Hochhauser, D
Citation: B. Tolner et al., Transcriptional regulation of topoisomerase II alpha at confluence and pharmacological modulation of expression by bis-benzimidazole drugs, MOLEC PHARM, 59(4), 2001, pp. 699-706
Design, synthesis, and evaluation of a novel pyrrolobenzodiazepine DNA-interactive agent with highly efficient cross-linking ability and potent cytotoxicity
Authors: Gregson, SJ Howard, PW Hartley, JA Brooks, NA Adams, LJ Jenkins, TC Kelland, LR Thurston, DE
Citation: Sj. Gregson et al., Design, synthesis, and evaluation of a novel pyrrolobenzodiazepine DNA-interactive agent with highly efficient cross-linking ability and potent cytotoxicity, J MED CHEM, 44(5), 2001, pp. 737-748
Autologous plasma activates Akt/protein kinase B and enhances basal survival and resistance to DNA damage-induced apoptosis in B-chronic lymphocytic leukaemia cells
Authors: Wickremasinghe, RG Ganeshaguru, K Jones, DT Lindsay, C Spanswick, VJ Hartley, JA Wadhwa, M Thorpe, R Hoffbrand, AV Prentice, HG Mehta, AB
Citation: Rg. Wickremasinghe et al., Autologous plasma activates Akt/protein kinase B and enhances basal survival and resistance to DNA damage-induced apoptosis in B-chronic lymphocytic leukaemia cells, BR J HAEM, 114(3), 2001, pp. 608-615
Measurement of the critical DNA lesions produced by antibody-directed enzyme prodrug therapy (ADEPT) in vitro, in vivo and in clinical material
Authors: Webley, SD Francis, RJ Pedley, RB Sharma, SK Begent, RHJ Hartley, JA Hochhauser, D
Citation: Sd. Webley et al., Measurement of the critical DNA lesions produced by antibody-directed enzyme prodrug therapy (ADEPT) in vitro, in vivo and in clinical material, BR J CANC, 84(12), 2001, pp. 1671-1676
Synthesis, cytotoxicity and DNA cross-linking activity of symmetrical dimers based upon the epoxide domain of the azinomycins
Authors: Hartley, JA Hazrati, A Hodgkinson, TJ Kelland, LR Khanim, R Shipman, M Suzenet, F
Citation: Ja. Hartley et al., Synthesis, cytotoxicity and DNA cross-linking activity of symmetrical dimers based upon the epoxide domain of the azinomycins, PHYS CHEM P, 2(23), 2000, pp. 2325-2326
A synthetic azinomycin analogue with demonstrated DNA cross-linking activity: Insights into the mechanism of action of this class of antitumor agent
Authors: Hartley, JA Hazrati, A Kelland, LR Khanim, R Shipman, M Suzenet, F Walker, LF
Citation: Ja. Hartley et al., A synthetic azinomycin analogue with demonstrated DNA cross-linking activity: Insights into the mechanism of action of this class of antitumor agent, ANGEW CHEM, 39(19), 2000, pp. 3467
Synthesis, cytotoxicity and DNA cross-linking activity of symmetrical dimers based upon the epoxide domain of the azinomycins
Authors: Hartley, JA Hazrati, A Hodgkinson, TJ Kelland, LR Khanim, R Shipman, M Suzenet, F
Citation: Ja. Hartley et al., Synthesis, cytotoxicity and DNA cross-linking activity of symmetrical dimers based upon the epoxide domain of the azinomycins, CHEM COMMUN, (23), 2000, pp. 2325-2326
Mechanisms of action of quinone-containing alkylating agents: DNA alkylation by aziridinylquinones
Authors: Hargreaves, RHJ Hartley, JA Butler, J
Citation: Rhj. Hargreaves et al., Mechanisms of action of quinone-containing alkylating agents: DNA alkylation by aziridinylquinones, FRONT BIOSC, 5, 2000, pp. E172-E180
Alteration in the choice of DNA repair pathway with increasing sequence selective DNA alkylation in the minor groove
Authors: Brooks, N McHugh, PJ Lee, M Hartley, JA
Citation: N. Brooks et al., Alteration in the choice of DNA repair pathway with increasing sequence selective DNA alkylation in the minor groove, CHEM BIOL, 7(9), 2000, pp. 659-668
Defining the roles of nucleotide excision repair and recombination in the repair of DNA interstrand cross-links in mammalian cells
Authors: De Silva, IU McHugh, PJ Clingen, PH Hartley, JA
Citation: Iu. De Silva et al., Defining the roles of nucleotide excision repair and recombination in the repair of DNA interstrand cross-links in mammalian cells, MOL CELL B, 20(21), 2000, pp. 7980-7990
Repair of intermediate structures produced at DNA interstrand cross-links in Saccharomyces cerevisiae
Authors: McHugh, PJ Sones, WR Hartley, JA
Citation: Pj. Mchugh et al., Repair of intermediate structures produced at DNA interstrand cross-links in Saccharomyces cerevisiae, MOL CELL B, 20(10), 2000, pp. 3425-3433
The abnormal cytotoxicities of 2,5-diaziridinyl-1,4-benzoquinone-3-phenyl esters
Authors: Di Francesco, AM Hargreaves, RHJ Wallace, TW Mayalarp, SP Hazratis, A Hartley, JA Butler, J
Citation: Am. Di Francesco et al., The abnormal cytotoxicities of 2,5-diaziridinyl-1,4-benzoquinone-3-phenyl esters, ANTI-CAN DR, 15(5), 2000, pp. 347-359
Synthesis of new homochiral bispyrrolidines as potential DNA cross-linkingantitumour agents
Authors: Anderson, FM O'Hare, CC Hartley, JA Robins, DJ
Citation: Fm. Anderson et al., Synthesis of new homochiral bispyrrolidines as potential DNA cross-linkingantitumour agents, ANTI-CAN DR, 15(2), 2000, pp. 119-126
Anthraquinone-oligodeoxynucleotide conjugates as inhibitors of gene transcription
Authors: Gibson, V Anderson, RJ Hartley, JA McAdam, SR Cairns, D
Citation: V. Gibson et al., Anthraquinone-oligodeoxynucleotide conjugates as inhibitors of gene transcription, J PHARM PHA, 52(6), 2000, pp. 599-602
Symmetric bis-benzimidazoles: new sequence-selective DNA-binding molecules
Authors: Neidle, S Mann, J Rayner, EL Baron, A Opoku-Boahen, Y Simpson, IJ Smith, NJ Fox, NJ Fox, KR Hartley, JA Kelland, LR
Citation: S. Neidle et al., Symmetric bis-benzimidazoles: new sequence-selective DNA-binding molecules, CHEM COMMUN, (10), 1999, pp. 929-930
Measurement of DNA cross-linking in patients on ifosfamide therapy using the single cell gel electrophoresis (comet) assay
Authors: Hartley, JM Spanswick, VJ Gander, M Giacomini, G Whelan, J Souhami, RL Hartley, JA
Citation: Jm. Hartley et al., Measurement of DNA cross-linking in patients on ifosfamide therapy using the single cell gel electrophoresis (comet) assay, CLIN CANC R, 5(3), 1999, pp. 507-512
Defective repair of cisplatin-induced DNA damage caused by reduced XPA protein in testicular germ cell tumours
Authors: Koberle, B Masters, JRW Hartley, JA Wood, RD
Citation: B. Koberle et al., Defective repair of cisplatin-induced DNA damage caused by reduced XPA protein in testicular germ cell tumours, CURR BIOL, 9(5), 1999, pp. 273-276
Excision repair of nitrogen mustard-DNA adducts in Saccharomyces cerevisiae
Authors: McHugh, PJ Gill, RD Waters, R Hartley, JA
Citation: Pj. Mchugh et al., Excision repair of nitrogen mustard-DNA adducts in Saccharomyces cerevisiae, NUCL ACID R, 27(16), 1999, pp. 3259-3266
The role of base excision repair in the repair of DNA adducts formed by a series of nitrogen mustard-containing analogues of distamycin of increasingbinding site size
Authors: Brooks, N McHugh, PJ Lee, M Hartley, JA
Citation: N. Brooks et al., The role of base excision repair in the repair of DNA adducts formed by a series of nitrogen mustard-containing analogues of distamycin of increasingbinding site size, ANTI-CAN DR, 14(1), 1999, pp. 11-18
Design, synthesis, and evaluation of a novel sequence-selective epoxide-containing DNA cross-linking agent based on the pyrrolo[2,1-c][1,4]benzodiazepine system
Authors: Wilson, SC Howard, PW Forrow, SM Hartley, JA Adams, LJ Jenkins, TC Kelland, LR Thurston, DE
Citation: Sc. Wilson et al., Design, synthesis, and evaluation of a novel sequence-selective epoxide-containing DNA cross-linking agent based on the pyrrolo[2,1-c][1,4]benzodiazepine system, J MED CHEM, 42(20), 1999, pp. 4028-4041
Cross-linking and sequence-specific alkylation of DNA by aziridinylquinones. 3. Effects of alkyl substituents
Authors: Hargreaves, RHJ O'Hare, CC Hartley, JA Ross, D Butler, J
Citation: Rhj. Hargreaves et al., Cross-linking and sequence-specific alkylation of DNA by aziridinylquinones. 3. Effects of alkyl substituents, J MED CHEM, 42(12), 1999, pp. 2245-2250
DNA alkylation and interstrand cross-linking by treosulfan
Authors: Hartley, JA O'Hare, CC Baumgart, J
Citation: Ja. Hartley et al., DNA alkylation and interstrand cross-linking by treosulfan, BR J CANC, 79(2), 1999, pp. 264-266
Risultati: 1-25 | 26-30