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Results: 1-15 |
Results: 15
Substituent effects within the DNA binding subunit of CBI analogues of theduocarmycins and CC-1065
Authors: Boger, DL Stauffer, F Hedrick, MP
Citation: Dl. Boger et al., Substituent effects within the DNA binding subunit of CBI analogues of theduocarmycins and CC-1065, BIOORG MED, 11(15), 2001, pp. 2021-2024
alpha-Keto heterocycle inhibitors of fatty acid amide hydrolase: Carbonyl group modification and alpha-substitution
Authors: Boger, DL Miyauchi, H Hedrick, MP
Citation: Dl. Boger et al., alpha-Keto heterocycle inhibitors of fatty acid amide hydrolase: Carbonyl group modification and alpha-substitution, BIOORG MED, 11(12), 2001, pp. 1517-1520
Behavioral evidence for the interaction of oleamide with multiple neurotransmitter systems
Authors: Fedorova, I Hashimoto, A Fecik, RA Hedrick, MP Hanus, LO Boger, DL Rice, KC Basile, AS
Citation: I. Fedorova et al., Behavioral evidence for the interaction of oleamide with multiple neurotransmitter systems, J PHARM EXP, 299(1), 2001, pp. 332-342
Synthesis, chemical properties, and biological evaluation of CC-1065 and duocarmycin analogues incorporating the 5-methoxycarbonyl-1,2,9,9a-tetrahydrocyclopropa[c]benz[e]indol-4-one alkylation subunit
Authors: Boger, DL Hughes, TV Hedrick, MP
Citation: Dl. Boger et al., Synthesis, chemical properties, and biological evaluation of CC-1065 and duocarmycin analogues incorporating the 5-methoxycarbonyl-1,2,9,9a-tetrahydrocyclopropa[c]benz[e]indol-4-one alkylation subunit, J ORG CHEM, 66(7), 2001, pp. 2207-2216
Parallel synthesis and evaluation of 132 (+)-1,2,9,9a-tetrahydrocyclopropa[c]benz[e]indol-4-one (CBI) analogues of CC-1065 and the duocarmycins defining the contribution of the DNA-binding domain
Authors: Boger, DL Schmitt, HW Fink, BE Hedrick, MP
Citation: Dl. Boger et al., Parallel synthesis and evaluation of 132 (+)-1,2,9,9a-tetrahydrocyclopropa[c]benz[e]indol-4-one (CBI) analogues of CC-1065 and the duocarmycins defining the contribution of the DNA-binding domain, J ORG CHEM, 66(20), 2001, pp. 6654-6661
Total syntheses of thiocoraline and BE-22179 and assessment of their DNA binding and biological properties
Authors: Boger, DL Ichikawa, S Tse, WC Hedrick, MP Jin, Q
Citation: Dl. Boger et al., Total syntheses of thiocoraline and BE-22179 and assessment of their DNA binding and biological properties, J AM CHEM S, 123(4), 2001, pp. 561-568
A simple, high-resolution method for establishing DNA binding affinity andsequence selectivity
Authors: Boger, DL Fink, BE Brunette, SR Tse, WC Hedrick, MP
Citation: Dl. Boger et al., A simple, high-resolution method for establishing DNA binding affinity andsequence selectivity, J AM CHEM S, 123(25), 2001, pp. 5878-5891
Assessment of solution-phase positional scanning libraries based on distamycin A for the discovery of new DNA binding agents
Authors: Boger, DL Dechantsreiter, MA Ishii, T Fink, BE Hedrick, MP
Citation: Dl. Boger et al., Assessment of solution-phase positional scanning libraries based on distamycin A for the discovery of new DNA binding agents, BIO MED CH, 8(8), 2000, pp. 2049-2057
Conformationally restricted analogues designed for selective inhibition ofGAR Tfase versus thymidylate synthase or dihydrofolate reductase
Authors: Boger, DL Labroli, MA Marsilje, TH Jin, Q Hedrick, MP Baker, SJ Shim, JH Benkovic, SJ
Citation: Dl. Boger et al., Conformationally restricted analogues designed for selective inhibition ofGAR Tfase versus thymidylate synthase or dihydrofolate reductase, BIO MED CH, 8(5), 2000, pp. 1075-1086
Design, synthesis, and biological evaluation of fluoronitrophenyl substituted folate analogues as potential inhibitors of GAR transformylase and AICAR transformylase
Authors: Boger, DL Marsilje, TH Castro, RA Hedrick, MP Jin, Q Baker, SJ Shim, JH Benkovic, SJ
Citation: Dl. Boger et al., Design, synthesis, and biological evaluation of fluoronitrophenyl substituted folate analogues as potential inhibitors of GAR transformylase and AICAR transformylase, BIOORG MED, 10(13), 2000, pp. 1471-1475
A new class of highly cytotoxic diketopiperazines
Authors: Boger, DL Fink, BE Hedrick, MP
Citation: Dl. Boger et al., A new class of highly cytotoxic diketopiperazines, BIOORG MED, 10(10), 2000, pp. 1019-1020
Exceptionally potent inhibitors of fatty acid amide hydrolase: The enzyme responsible for degradation of endogenous oleamide and anandamide
Authors: Boger, DL Sato, H Lerner, AE Hedrick, MP Fecik, RA Miyauchi, H Wilkie, GD Austin, BJ Patricelli, MP Cravatt, BF
Citation: Dl. Boger et al., Exceptionally potent inhibitors of fatty acid amide hydrolase: The enzyme responsible for degradation of endogenous oleamide and anandamide, P NAS US, 97(10), 2000, pp. 5044-5049
Total synthesis of ningalin B utilizing a heterocyclic azadiene Diels-Alder reaction and discovery of a new class of potent multidrug resistant (MDR)reversal agents
Authors: Boger, DL Soenen, DR Boyce, CW Hedrick, MP Jin, Q
Citation: Dl. Boger et al., Total synthesis of ningalin B utilizing a heterocyclic azadiene Diels-Alder reaction and discovery of a new class of potent multidrug resistant (MDR)reversal agents, J ORG CHEM, 65(8), 2000, pp. 2479-2483
Synthesis and evaluation of 1,2,8,8a-tetrahydrocyclopropa[c]pyrrolo[3,2-e]indol-4(5H)-one, the parent alkylation subunit of CC-1065 and the duocarmycins: Impact of the alkylation subunit substituents and its implications forDNA alkylation catalysis
Authors: Boger, DL Santillan, A Searcey, M Brunette, SR Wolkenberg, SE Hedrick, MP Jin, Q
Citation: Dl. Boger et al., Synthesis and evaluation of 1,2,8,8a-tetrahydrocyclopropa[c]pyrrolo[3,2-e]indol-4(5H)-one, the parent alkylation subunit of CC-1065 and the duocarmycins: Impact of the alkylation subunit substituents and its implications forDNA alkylation catalysis, J ORG CHEM, 65(13), 2000, pp. 4101-4111
Total synthesis of distamycin A and 2640 analogues: A solution-phase combinatorial approach to the discovery of new, bioactive DNA binding agents anddevelopment of a rapid, high-throughput screen for determining relative DNA binding affinity or DNA binding sequence selectivity
Authors: Boger, DL Fink, BE Hedrick, MP
Citation: Dl. Boger et al., Total synthesis of distamycin A and 2640 analogues: A solution-phase combinatorial approach to the discovery of new, bioactive DNA binding agents anddevelopment of a rapid, high-throughput screen for determining relative DNA binding affinity or DNA binding sequence selectivity, J AM CHEM S, 122(27), 2000, pp. 6382-6394
Risultati: 1-15 |