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1-18
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Results: 18
Authors:
Aherne, GW
Hardcastle, A
Ward, E
Dobinson, D
Crompton, T
Valenti, M
Brunton, L
Jackman, AL
Citation: Gw. Aherne et al., Pharmacokinetic/pharmacodynamic study of ZD9331, a nonpolyglutamatable inhibitor of thymidylate synthase, in a murine model following two curative administration schedules, CLIN CANC R, 7(9), 2001, pp. 2923-2930
Authors:
Bavetsias, V
Marriott, JH
Theti, DS
Melin, JC
Wilson, SC
Jackman, AL
Citation: V. Bavetsias et al., Cyclopenta[g]quinazoline-based antifolates: The effect of the chirality atthe 6-position on the inhibition of thymidylate synthase (TS), BIOORG MED, 11(23), 2001, pp. 3015-3017
Authors:
van der Wilt, CL
Backus, HHJ
Smid, K
Comijn, L
Veerman, G
Wouters, D
Voorn, DA
Priest, DG
Bunni, MA
Mitchell, F
Jackman, AL
Jansen, G
Peters, GJ
Citation: Cl. Van Der Wilt et al., Modulation of both endogenous folates and thymidine enhance the therapeutic efficacy of thymidylate synthase inhibitors, CANCER RES, 61(9), 2001, pp. 3675-3681
Authors:
Webley, SD
Welsh, SJ
Jackman, AL
Aherne, GW
Citation: Sd. Webley et al., The ability to accumulate deoxyuridine triphosphate and cellular response to thymidylate synthase (TS) inhibition, BR J CANC, 85(3), 2001, pp. 446-452
Authors:
Mitchell, F
Lynn, S
Jackman, AL
Citation: F. Mitchell et al., Modified high-performance liquid chromatography assay for the measurement of 2 '-deoxyuridine in human plasma and its application to pharmacodynamic studies of antimetabolite drugs, J CHROMAT B, 744(2), 2000, pp. 351-358
Authors:
Farrugia, DC
Aherne, GW
Brunton, L
Clarke, SJ
Jackman, AL
Citation: Dc. Farrugia et al., Leucovorin rescue from raltitrexed (Tomudex)-induced antiproliferative effects: In vitro cell line and in vivo mouse studies, CLIN CANC R, 6(9), 2000, pp. 3646-3656
Authors:
Welsh, SJ
Titley, J
Brunton, L
Valenti, M
Monaghan, P
Jackman, AL
Aherne, GW
Citation: Sj. Welsh et al., Comparison of thymidylate synthase (TS) protein up-regulation after exposure to TS inhibitors in normal and tumor cell lines and tissues, CLIN CANC R, 6(6), 2000, pp. 2538-2546
Authors:
Pritchard, DM
Bower, L
Potten, CS
Jackman, AL
Hickman, JA
Citation: Dm. Pritchard et al., The importance of p53-independent apoptosis in the intestinal toxicity induced by raltitrexed (ZD1694, Tomudex): Genetic differences between BALB/c and DBA/2 mice, CLIN CANC R, 6(11), 2000, pp. 4389-4395
Authors:
Clarke, SJ
Farrugia, DC
Aherne, GW
Pritchard, DM
Benstead, J
Jackman, AL
Citation: Sj. Clarke et al., Balb/c mice as a preclinical model for raltitrexed-induced gastrointestinal toxicity, CLIN CANC R, 6(1), 2000, pp. 285-296
Authors:
Bavetsias, V
Marriott, JH
Melin, C
Kimbell, R
Matusiak, ZS
Boyle, FT
Jackman, AL
Citation: V. Bavetsias et al., Design and synthesis of cyclopenta[g]quinazoline-based antifolates as inhibitors of thymidylate synthase and potential antitumor agents, J MED CHEM, 43(10), 2000, pp. 1910-1926
Authors:
Webley, SD
Hardcastle, A
Ladner, RD
Jackman, AL
Aherne, GW
Citation: Sd. Webley et al., Deoxyuridine triphosphatase (dUTPase) expression and sensitivity to the thymidylate synthase (TS) inhibitor ZD9331, BR J CANC, 83(6), 2000, pp. 792-799
Authors:
Jackman, AL
Kimbel, R
Ford, HER
Citation: Al. Jackman et al., Combination of raltitrexed with other cytotoxic agents: Rationale and preclinical observations, EUR J CANC, 35, 1999, pp. S3-S8
Authors:
Marriott, JH
Neidle, S
Matusiak, Z
Bavetsias, V
Jackman, AL
Melin, C
Boyle, FT
Citation: Jh. Marriott et al., Chemoenzymatic preparation of the novel antifolate thymidylate synthase inhibitor N-(4-{N-[(6S)-2-methyl-4-oxo-3,4,7,8-tetrahydro-6H-cyclopenta [g]quinazolin-6-yl]-N-(prop-2-ynyl)amino}-benzoyl)-L-glutamic acid and its glutamyl cleavage product, J CHEM S P1, (11), 1999, pp. 1495-1503
Authors:
Marsham, PR
Wardleworth, JM
Boyle, FT
Hennequin, LF
Kimbell, R
Brown, M
Jackman, AL
Citation: Pr. Marsham et al., Design and synthesis of potent non-polyglutamatable quinazoline antifolatethymidylate synthase inhibitors, J MED CHEM, 42(19), 1999, pp. 3809-3820
Authors:
Rohlff, C
Watson, SA
Morris, TM
Skelton, L
Jackman, AL
Page, MJ
Citation: C. Rohlff et al., A novel, orally administered nucleoside analogue, OGT 719, inhibits the liver invasive growth of a human colorectal tumor, C170HM2, CANCER RES, 59(6), 1999, pp. 1268-1272
Authors:
Skelton, LA
Ormerod, MG
Titley, J
Kimbell, R
Brunton, LA
Jackman, AL
Citation: La. Skelton et al., A novel class of lipophilic quinazoline-based folic acid analogues: cytotoxic agents with a folate-independent locus, BR J CANC, 79(11-12), 1999, pp. 1692-1701
Authors:
Hughes, LR
Stephens, TC
Boyle, FT
Jackman, AL
Citation: Lr. Hughes et al., Raltitrexed (Tomudex (TM)), a highly polyglutamatable antifolate thymidylate synthase inhibitor - Design and preclinical activity, CANC DRUG, 1999, pp. 147-165
Authors:
Boyle, FT
Stephens, TC
Averbuch, SD
Jackman, AL
Citation: Ft. Boyle et al., ZD9331 - Preclinical and clinical studies, CANC DRUG, 1999, pp. 243-260
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