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Results: 1-25 | 26-30
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THE DURATION OF VIRAL SUPPRESSION DURING PROTEASE INHIBITOR THERAPY FOR HIV-1 INFECTION IS PREDICTED BY PLASMA HIV-1 RNA AT THE NADIR
Authors: KEMPF DJ RODE RA XU Y SUN E HEATHCHIOZZI ME VALDES J JAPOUR AJ DANNER S BOUCHER C MOLLA A LEONARD JM
Citation: Dj. Kempf et al., THE DURATION OF VIRAL SUPPRESSION DURING PROTEASE INHIBITOR THERAPY FOR HIV-1 INFECTION IS PREDICTED BY PLASMA HIV-1 RNA AT THE NADIR, AIDS, 12(5), 1998, pp. 9-14
RECENT DEVELOPMENTS IN HIV PROTEASE INHIBITOR THERAPY
Authors: MOLLA A GRANNEMAN GR SUN E KEMPF DJ
Citation: A. Molla et al., RECENT DEVELOPMENTS IN HIV PROTEASE INHIBITOR THERAPY, Antiviral research, 39(1), 1998, pp. 1-23
HUMAN SERUM ATTENUATES THE ACTIVITY OF PROTEASE INHIBITORS TOWARD WILD-TYPE AND MUTANT HUMAN-IMMUNODEFICIENCY-VIRUS
Authors: MOLLA A VASAVANONDA S KUMAR G SHAM HL JOHNSON M GRABOWSKI B DENISSEN JF KOHLBRENNER W PLATTNER JJ LEONARD JM NORBECK DW KEMPF DJ
Citation: A. Molla et al., HUMAN SERUM ATTENUATES THE ACTIVITY OF PROTEASE INHIBITORS TOWARD WILD-TYPE AND MUTANT HUMAN-IMMUNODEFICIENCY-VIRUS, Virology (New York, N.Y. Print), 250(2), 1998, pp. 255-262
IN-VITRO SELECTION AND CHARACTERIZATION OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 VARIANTS WITH INCREASED RESISTANCE TO ABT-378, A NOVEL PROTEASE INHIBITOR
Authors: CARRILLO A STEWART KD SHAM HL NORBECK DW KOHLBRENNER WE LEONARD JM KEMPF DJ MOLLA A
Citation: A. Carrillo et al., IN-VITRO SELECTION AND CHARACTERIZATION OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 VARIANTS WITH INCREASED RESISTANCE TO ABT-378, A NOVEL PROTEASE INHIBITOR, Journal of virology, 72(9), 1998, pp. 7532-7541
DISCOVERY OF RITONAVIR, A POTENT INHIBITOR OF HIV PROTEASE WITH HIGH ORAL BIOAVAILABILITY AND CLINICAL EFFICACY
Authors: KEMPF DJ SHAM HL MARSH KC FLENTGE CA BETEBENNER D GREEN BE MCDONALD E VASAVANONDA S SALDIVAR A WIDEBURG NE KATI WM RUIZ L ZHAO C FINO LM PATTERSON J MOLLA A PLATTNER JJ NORBECK DW
Citation: Dj. Kempf et al., DISCOVERY OF RITONAVIR, A POTENT INHIBITOR OF HIV PROTEASE WITH HIGH ORAL BIOAVAILABILITY AND CLINICAL EFFICACY, Journal of medicinal chemistry, 41(4), 1998, pp. 602-617
LACK OF STEREOSPECIFICITY IN THE BINDING OF THE P2 AMINO-ACID OF RITONAVIR TO HIV PROTEASE
Authors: KEMPF DJ MOLLA A MARSH KC PARK C RODRIGUES AD KORNEYEVA M VASAVANONDA S MCDONALD E FLENTGE CA MUCHMORE S WIDEBURG NE SALDIVAR A COOPER A KATI WM STEWART KD NORBECK DW
Citation: Dj. Kempf et al., LACK OF STEREOSPECIFICITY IN THE BINDING OF THE P2 AMINO-ACID OF RITONAVIR TO HIV PROTEASE, Bioorganic & medicinal chemistry letters, 7(6), 1997, pp. 699-704
METABOLISM AND DISPOSITION OF THE HIV-1 PROTEASE INHIBITOR RITONAVIR (ABT-538) IN RATS, DOGS, AND HUMANS
Authors: DENISSEN JF GRABOWSKI BA JOHNSON MK BUKO AM KEMPF DJ THOMAS SB SURBER BW
Citation: Jf. Denissen et al., METABOLISM AND DISPOSITION OF THE HIV-1 PROTEASE INHIBITOR RITONAVIR (ABT-538) IN RATS, DOGS, AND HUMANS, Drug metabolism and disposition, 25(4), 1997, pp. 489-501
PHARMACOKINETIC ENHANCEMENT OF INHIBITORS OF THE HUMAN-IMMUNODEFICIENCY-VIRUS PROTEASE BY COADMINISTRATION WITH RITONAVIR
Authors: KEMPF DJ MARSH KC KUMAR G RODRIGUES AD DENISSEN JF MCDONALD E KUKULKA MJ HSU A GRANNEMAN GR BAROLDI PA SUN E PIZZUTI D PLATTNER JJ NORBECK DW LEONARD JM
Citation: Dj. Kempf et al., PHARMACOKINETIC ENHANCEMENT OF INHIBITORS OF THE HUMAN-IMMUNODEFICIENCY-VIRUS PROTEASE BY COADMINISTRATION WITH RITONAVIR, Antimicrobial agents and chemotherapy, 41(3), 1997, pp. 654-660
NMR-BASED DISCOVERY OF LEAD INHIBITORS THAT BLOCK DNA-BINDING OF THE HUMAN-PAPILLOMAVIRUS E2 PROTEIN
Authors: HAJDUK PJ DINGES J MIKNIS GF MERLOCK M MIDDLETON T KEMPF DJ EGAN DA WALTER KA ROBINS TS SHUKER SB HOLZMAN TF FESIK SW
Citation: Pj. Hajduk et al., NMR-BASED DISCOVERY OF LEAD INHIBITORS THAT BLOCK DNA-BINDING OF THE HUMAN-PAPILLOMAVIRUS E2 PROTEIN, Journal of medicinal chemistry, 40(20), 1997, pp. 3144-3150
ORDERED ACCUMULATION OF MUTATIONS IN HIV PROTEASE CONFERS RESISTANCE TO RITONAVIR
Authors: MOLLA A KORNEYEVA M GAO Q VASAVANONDA S SCHIPPER PJ MO HM MARKOWITZ M CHERNYAVSKIY T NIU P LYONS N HSU A GRANNEMAN GR HO DD BOUCHER CAB LEONARD JM NORBECK DW KEMPF DJ
Citation: A. Molla et al., ORDERED ACCUMULATION OF MUTATIONS IN HIV PROTEASE CONFERS RESISTANCE TO RITONAVIR, Nature medicine, 2(7), 1996, pp. 760-766
EVALUATION OF FUROFURAN AS A P-2 LIGAND FOR SYMMETRY-BASED HIV PROTEASE INHIBITORS
Authors: CHEN XQ LI L KEMPF DJ SHAM H WIDEBURG NE SALDIVAR A VASAVANONDA S MARSH KC MCDONALD E NORBECK DW
Citation: Xq. Chen et al., EVALUATION OF FUROFURAN AS A P-2 LIGAND FOR SYMMETRY-BASED HIV PROTEASE INHIBITORS, Bioorganic & medicinal chemistry letters, 6(23), 1996, pp. 2847-2852
HUMAN SERUM ALPHA(1) ACID GLYCOPROTEIN REDUCES UPTAKE, INTRACELLULAR CONCENTRATION, AND ANTIVIRAL ACTIVITY OF A-80987, AN INHIBITOR OF THE HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 PROTEASE
Authors: BILELLO JA BILELLO PA STELLRECHT K LEONARD J NORBECK DW KEMPF DJ ROBINS T DRUSANO GL
Citation: Ja. Bilello et al., HUMAN SERUM ALPHA(1) ACID GLYCOPROTEIN REDUCES UPTAKE, INTRACELLULAR CONCENTRATION, AND ANTIVIRAL ACTIVITY OF A-80987, AN INHIBITOR OF THE HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 PROTEASE, Antimicrobial agents and chemotherapy, 40(6), 1996, pp. 1491-1497
A NOVEL, PICOMOLAR INHIBITOR OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 PROTEASES
Authors: SHAM HL ZHAO C STEWART KD BETEBENNER DA LIN SQ PARK CH KONG XP ROSENBROOK W HERRIN T MADIGAN D VASAVANONDA S LYONS N MOLLA A SALDIVAR A MARSH KC MCDONALD E WIDEBURG NE DENISSEN JF ROBINS T KEMPF DJ PLATTNER JJ NORBECK DW
Citation: Hl. Sham et al., A NOVEL, PICOMOLAR INHIBITOR OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 PROTEASES, Journal of medicinal chemistry, 39(2), 1996, pp. 392-397
EVALUATION OF SUBSTITUTED BENZAMIDES AS P2 LIGANDS FOR SYMMETRY-BASEDINHIBITORS OF HIV PROTEASE
Authors: KEMPF DJ FLENTGE CA WIDEBURG NE SALDIVAR A VASAVANONDA S NORBECK DW
Citation: Dj. Kempf et al., EVALUATION OF SUBSTITUTED BENZAMIDES AS P2 LIGANDS FOR SYMMETRY-BASEDINHIBITORS OF HIV PROTEASE, Bioorganic & medicinal chemistry letters, 5(22), 1995, pp. 2725-2728
CONVENIENT SYNTHESIS OF -(T-BUTYLOXYCARBONYLAMINO)-2'-PHENYLETHYL]OXIRANE, A VERSATILE INTERMEDIATE FOR THE PREPARATION OF HYDROXYETHYLAMINE BASED HIV PROTEASE INHIBITORS
Authors: GREEN BE CHEN XQ NORBECK DW KEMPF DJ
Citation: Be. Green et al., CONVENIENT SYNTHESIS OF -(T-BUTYLOXYCARBONYLAMINO)-2'-PHENYLETHYL]OXIRANE, A VERSATILE INTERMEDIATE FOR THE PREPARATION OF HYDROXYETHYLAMINE BASED HIV PROTEASE INHIBITORS, Synlett, (6), 1995, pp. 613-614
ABT-538 IS A POTENT INHIBITOR OF HUMAN-IMMUNODEFICIENCY-VIRUS PROTEASE AND HAS HIGH ORAL BIOAVAILABILITY IN HUMANS
Authors: KEMPF DJ MARSH KC DENISSEN JF MCDONALD E VASAVANONDA S FLENTGE CA GREEN BE FINO L PARK CH KONG XP WIDEBURG NE SALDIVAR A RUIZ L KATI WM SHAM HL ROBINS T STEWART KD HSU A PLATTNER JJ LEONARD JM NORBECK DW
Citation: Dj. Kempf et al., ABT-538 IS A POTENT INHIBITOR OF HUMAN-IMMUNODEFICIENCY-VIRUS PROTEASE AND HAS HIGH ORAL BIOAVAILABILITY IN HUMANS, Proceedings of the National Academy of Sciences of the United Statesof America, 92(7), 1995, pp. 2484-2488
SELECTION AND ANALYSIS OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-I VARIANTS WITH INCREASED RESISTANCE TO ABT-538, A NOVEL PROTEASE INHIBITOR
Authors: MARKOWITZ M MO HM KEMPF DJ NORBECK DW BHAT TN ERICKSON JW HO DD
Citation: M. Markowitz et al., SELECTION AND ANALYSIS OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-I VARIANTS WITH INCREASED RESISTANCE TO ABT-538, A NOVEL PROTEASE INHIBITOR, Journal of virology, 69(2), 1995, pp. 701-706
SYNTHETIC CHEMICAL DIVERSITY - SOLID-PHASE SYNTHESIS OF LIBRARIES OF C-2 SYMMETRICAL INHIBITORS OF HIV PROTEASE CONTAINING DIAMINO DIOL ANDDIAMINO ALCOHOL CORES
Authors: WANG GT LI S WIDEBURG N KRAFFT GA KEMPF DJ
Citation: Gt. Wang et al., SYNTHETIC CHEMICAL DIVERSITY - SOLID-PHASE SYNTHESIS OF LIBRARIES OF C-2 SYMMETRICAL INHIBITORS OF HIV PROTEASE CONTAINING DIAMINO DIOL ANDDIAMINO ALCOHOL CORES, Journal of medicinal chemistry, 38(16), 1995, pp. 2995-3002
HIGHLY EFFICIENT SYNTHESIS OF -2-AMINO-4,4-DIFLUORO-1,6-DIPHENYL-3-HYDROXYHEXANE - THE KEY INTERMEDIATE FOR A SERIES OF POTENT HIV PROTEINASE-INHIBITORS
Authors: SHAM HL BETEBENNER DA WIDEBURG NE KEMPF DJ PLATTNER JJ NORBECK DW
Citation: Hl. Sham et al., HIGHLY EFFICIENT SYNTHESIS OF -2-AMINO-4,4-DIFLUORO-1,6-DIPHENYL-3-HYDROXYHEXANE - THE KEY INTERMEDIATE FOR A SERIES OF POTENT HIV PROTEINASE-INHIBITORS, Journal of fluorine chemistry, 73(2), 1995, pp. 221-224
POTENT INHIBITORS OF THE HIV-1 PROTEASE WITH GOOD ORAL BIOAVAILABILITIES
Authors: SHAM HL ZHAO C MARSH KC BETEBENNER DA LIN SQ MCDONALD E VASAVANONDA S WIDEBURG N SALDIVAR A ROBINS T KEMPF DJ PLATTNER JJ NORBECK DW
Citation: Hl. Sham et al., POTENT INHIBITORS OF THE HIV-1 PROTEASE WITH GOOD ORAL BIOAVAILABILITIES, Biochemical and biophysical research communications, 211(1), 1995, pp. 159-165
A C-2 SYMMETRY-BASED HIV PROTEASE INHIBITOR, A77003, IRREVERSIBLY INHIBITS INFECTIVITY OF HIV-1 IN-VITRO
Authors: KAGEYAMA S HOEKZEMA DT MURAKAWA Y KOJIMA E SHIRASAKA T KEMPF DJ NORBECK DW ERICKSON J MITSUYA H
Citation: S. Kageyama et al., A C-2 SYMMETRY-BASED HIV PROTEASE INHIBITOR, A77003, IRREVERSIBLY INHIBITS INFECTIVITY OF HIV-1 IN-VITRO, AIDS research and human retroviruses, 10(6), 1994, pp. 735-743
SYMMETRY-BASED INHIBITORS OF HIV PROTEASE - ORAL BIOAVAILABILITY AND RESISTANCE EMERGENCE
Authors: KEMPF DJ FLENTGE C MARSH KC MCDONALD E ROBINS T VASAVANONDA S CHEN CM WIDEBURG NE PARK C KONG XP DENISSEN J HO DD MARKOWITZ M TOYOSHIMA T SINGH MK ERICKSON J SHAM HL STEWART K GREEN BE TURON M SALDIVAR A NORBECK DW
Citation: Dj. Kempf et al., SYMMETRY-BASED INHIBITORS OF HIV PROTEASE - ORAL BIOAVAILABILITY AND RESISTANCE EMERGENCE, Journal of cellular biochemistry, 1994, pp. 130-130
BIOCHEMICAL-CHARACTERIZATION OF HIV-1 PROTEASE MUTANTS RESISTANT TO A-77003, A-80987
Authors: CHEN CM SALDIVAR A TURON M WIDEBURG NE ROBINS T VASAVANONDA S STEWART K PARK C KONG XP KEMPF DJ HO D ERICKSON J NORBECK DW
Citation: Cm. Chen et al., BIOCHEMICAL-CHARACTERIZATION OF HIV-1 PROTEASE MUTANTS RESISTANT TO A-77003, A-80987, Journal of cellular biochemistry, 1994, pp. 166-166
HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 VIRIONS COMPOSED OF UNPROCESSED GAG AND GAG-POL PRECURSORS ARE CAPABLE OF REVERSE TRANSCRIBING VIRAL GENOMIC RNA
Authors: KAPLAN AH KROGSTAD P KEMPF DJ NORBECK DW SWANSTROM R
Citation: Ah. Kaplan et al., HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 VIRIONS COMPOSED OF UNPROCESSED GAG AND GAG-POL PRECURSORS ARE CAPABLE OF REVERSE TRANSCRIBING VIRAL GENOMIC RNA, Antimicrobial agents and chemotherapy, 38(12), 1994, pp. 2929-2933
SELECTION OF MULTIPLE HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 VARIANTS THAT ENCODE VIRAL PROTEASES WITH DECREASED SENSITIVITY TO AN INHIBITOR OF THE VIRAL PROTEASE
Authors: KAPLAN AH MICHAEL SF WEHBIE RS KNIGGE MF PAUL DA EVERITT L KEMPF DJ NORBECK DW ERICKSON JW SWANSTROM R
Citation: Ah. Kaplan et al., SELECTION OF MULTIPLE HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 VARIANTS THAT ENCODE VIRAL PROTEASES WITH DECREASED SENSITIVITY TO AN INHIBITOR OF THE VIRAL PROTEASE, Proceedings of the National Academy of Sciences of the United Statesof America, 91(12), 1994, pp. 5597-5601
Risultati: 1-25 | 26-30