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Results: 1-23 |
Results: 23
PYRAZOLES, 1,2,4-TRIAZOLES, AND TETRAZOLES AS SURROGATES FOR CIS-AMIDE BONDS IN BORONATE ESTER THROMBIN INHIBITORS
Authors: DUNCIA JV SANTELLA JB HIGLEY CA VANATTEN MK WEBER PC ALEXANDER RS KETTNER CA PRUITT JR LIAUW AY QUAN ML KNABB RM WEXLER RR
Citation: Jv. Duncia et al., PYRAZOLES, 1,2,4-TRIAZOLES, AND TETRAZOLES AS SURROGATES FOR CIS-AMIDE BONDS IN BORONATE ESTER THROMBIN INHIBITORS, Bioorganic & medicinal chemistry letters, 8(7), 1998, pp. 775-780
RATIONAL DESIGN OF BOROPEPTIDE THROMBIN INHIBITORS - BETA,BETA-DIALKYLPHENETHYLGLYCINE P2 ANALOGS OF DUP-714 WITH GREATER SELECTIVITY OVER COMPLEMENT FACTOR-I AND AN IMPROVED SAFETY PROFILE
Authors: FEVIG JM BURIAK J CACCIOLA J ALEXANDER RS KETTNER CA KNABB RM PRUITT JR WEBER PC WEXLER RR
Citation: Jm. Fevig et al., RATIONAL DESIGN OF BOROPEPTIDE THROMBIN INHIBITORS - BETA,BETA-DIALKYLPHENETHYLGLYCINE P2 ANALOGS OF DUP-714 WITH GREATER SELECTIVITY OVER COMPLEMENT FACTOR-I AND AN IMPROVED SAFETY PROFILE, Bioorganic & medicinal chemistry letters, 8(3), 1998, pp. 301-306
SPECIFIC-INHIBITION OF PLASMA KALLIKREIN MODULATES CHRONIC GRANULOMATOUS INTESTINAL AND SYSTEMIC INFLAMMATION IN GENETICALLY SUSCEPTIBLE RATS
Authors: STADNICKI A SARTOR RB JANARDHAM R MAJLUFCRUZ A KETTNER CA ADAM AA COLMAN RW
Citation: A. Stadnicki et al., SPECIFIC-INHIBITION OF PLASMA KALLIKREIN MODULATES CHRONIC GRANULOMATOUS INTESTINAL AND SYSTEMIC INFLAMMATION IN GENETICALLY SUSCEPTIBLE RATS, The FASEB journal, 12(3), 1998, pp. 325-333
ACTIVATION OF THE KALLIKREIN-KININ SYSTEM IN ARTHRITIS AND ENTEROCOLITIS IN GENETICALLY SUSCEPTIBLE RATS - MODULATION BY A SELECTIVE PLASMAKALLIKREIN INHIBITOR
Authors: COLMAN RW STADNICKI A KETTNER CA ADAM AA DELACADENA RA SARTOR RB
Citation: Rw. Colman et al., ACTIVATION OF THE KALLIKREIN-KININ SYSTEM IN ARTHRITIS AND ENTEROCOLITIS IN GENETICALLY SUSCEPTIBLE RATS - MODULATION BY A SELECTIVE PLASMAKALLIKREIN INHIBITOR, Proceedings of the Association of American Physicians, 109(1), 1997, pp. 10-22
BIARYL SUBSTITUTED ALKYLBORONATE ESTERS AS THROMBIN INHIBITORS
Authors: QUAN ML WITYAK J DOMINGUEZ C DUNCIA JV KETTNER CA ELLIS CD LIAUW AY PARK JM SANTELLA JB KNABB RM THOOLEN MJ WEBER PC WEXLER RR
Citation: Ml. Quan et al., BIARYL SUBSTITUTED ALKYLBORONATE ESTERS AS THROMBIN INHIBITORS, Bioorganic & medicinal chemistry letters, 7(13), 1997, pp. 1595-1600
S-1 HETEROCYCLIC THROMBIN INHIBITORS
Authors: DOMINGUEZ C CARINI DJ WEBER PC KNABB RM ALEXANDER RS KETTNER CA WEXLER RR
Citation: C. Dominguez et al., S-1 HETEROCYCLIC THROMBIN INHIBITORS, Bioorganic & medicinal chemistry letters, 7(1), 1997, pp. 79-84
RESOLUTION OF ALPHA-AMINOBORONIC ESTERS BY DIASTEREOSELECTIVE CRYSTALLIZATION WITH PINANEDIOLS - CONFIRMATION BY X-RAY-ANALYSIS
Authors: BROSZ CS CALABRESE JC KETTNER CA TELEHA CA
Citation: Cs. Brosz et al., RESOLUTION OF ALPHA-AMINOBORONIC ESTERS BY DIASTEREOSELECTIVE CRYSTALLIZATION WITH PINANEDIOLS - CONFIRMATION BY X-RAY-ANALYSIS, Tetrahedron : asymmetry, 8(9), 1997, pp. 1435-1440
DESIGN AND SYNTHESIS OF RING-CONSTRAINED BOROPEPTIDE THROMBIN INHIBITORS
Authors: FEVIG JM ABELMAN MM BRITTELLI DR KETTNER CA KNABB RM WEBER PC
Citation: Jm. Fevig et al., DESIGN AND SYNTHESIS OF RING-CONSTRAINED BOROPEPTIDE THROMBIN INHIBITORS, Bioorganic & medicinal chemistry letters, 6(3), 1996, pp. 295-300
SYNTHESIS OF CONFORMATIONALLY-RESTRICTED BOROPEPTIDE THROMBIN INHIBITORS
Authors: CACCIOLA J FEVIG JM ALEXANDER RS BRITTELLI DR KETTNER CA KNABB RM WEBER PC
Citation: J. Cacciola et al., SYNTHESIS OF CONFORMATIONALLY-RESTRICTED BOROPEPTIDE THROMBIN INHIBITORS, Bioorganic & medicinal chemistry letters, 6(3), 1996, pp. 301-306
(N-ACYL-N-ALKYL)GLYCYL BOROLYSINE ANALOGS - A NEW CLASS OF POTENT THROMBIN INHIBITORS
Authors: GALEMMO RA FEVIG JM CARINI DJ CACCIOLA J WELLS BL HILLYER GL BURIAK J ROSSI KA STOUTEN PFW ALEXANDER RS HILMER R BOSTROM L ABELMAN MM LEE SL WEBER PC KETTNER CA KNABB RM WEXLER RR
Citation: Ra. Galemmo et al., (N-ACYL-N-ALKYL)GLYCYL BOROLYSINE ANALOGS - A NEW CLASS OF POTENT THROMBIN INHIBITORS, Bioorganic & medicinal chemistry letters, 6(24), 1996, pp. 2913-2918
SELECTIVE PLASMA KALLIKREIN INHIBITOR ATTENUATES ACUTE INTESTINAL INFLAMMATION IN LEWIS RAT
Authors: STADNICKI A DELACADENA RA SARTOR RB BENDER D KETTNER CA RATH HC ADAM A COLMAN RW
Citation: A. Stadnicki et al., SELECTIVE PLASMA KALLIKREIN INHIBITOR ATTENUATES ACUTE INTESTINAL INFLAMMATION IN LEWIS RAT, Digestive diseases and sciences, 41(5), 1996, pp. 912-920
THEE CONTACT SYSTEM IN EXPERIMENTAL ENTEROCOLITIS
Authors: STADNICKI A DELACADENA RA SARTOR RB KETTNER CA COLMAN RW
Citation: A. Stadnicki et al., THEE CONTACT SYSTEM IN EXPERIMENTAL ENTEROCOLITIS, Immunopharmacology, 33(1-3), 1996, pp. 314-316
NEW ASYMMETRIC-SYNTHESIS OF ALPHA-AMINOBORONIC ACIDS CONTAINING FUNCTIONALIZED SIDE-CHAINS
Authors: MANTRI P DUFFY DE KETTNER CA
Citation: P. Mantri et al., NEW ASYMMETRIC-SYNTHESIS OF ALPHA-AMINOBORONIC ACIDS CONTAINING FUNCTIONALIZED SIDE-CHAINS, Journal of organic chemistry, 61(16), 1996, pp. 5690-5692
ACUTE TOXICITY OF SYNTHETIC THROMBIN INHIBITORS CAUSED BY INHIBITION OF COMPLEMENT FACTOR-I
Authors: KNABB RM LUETTGEN JM LEAMY AW BARBERA FA KETTNER CA PANGBURN MJ THOOLEN MJ
Citation: Rm. Knabb et al., ACUTE TOXICITY OF SYNTHETIC THROMBIN INHIBITORS CAUSED BY INHIBITION OF COMPLEMENT FACTOR-I, Circulation, 94(8), 1996, pp. 4069-4069
STRUCTURE-BASED UNDERSTANDING OF LIGAND AFFINITY USING HUMAN THROMBINAS A MODEL SYSTEM
Authors: NIENABER VL MERSINGER LJ KETTNER CA
Citation: Vl. Nienaber et al., STRUCTURE-BASED UNDERSTANDING OF LIGAND AFFINITY USING HUMAN THROMBINAS A MODEL SYSTEM, Biochemistry, 35(30), 1996, pp. 9690-9699
INHIBITION OF PLASMA KALLIKREIN PREVENTS PEPTIDOGLYCAN-INDUCED ARTHRITIS IN THE LEWIS RAT
Authors: DELACADENA RA STADNICKI A UKNIS AB SARTOR RB KETTNER CA ADAM A COLMAN RW
Citation: Ra. Delacadena et al., INHIBITION OF PLASMA KALLIKREIN PREVENTS PEPTIDOGLYCAN-INDUCED ARTHRITIS IN THE LEWIS RAT, The FASEB journal, 9(5), 1995, pp. 446-452
NASAL MUCOSAL METABOLISM AND ABSORPTION OF PENTAPEPTIDE ENKEPHALIN ANALOGS HAVING VARYING N-TERMINAL AMINO-ACIDS
Authors: HUSSAIN MA SEETHARAM R WILK RR AUNGST BJ KETTNER CA
Citation: Ma. Hussain et al., NASAL MUCOSAL METABOLISM AND ABSORPTION OF PENTAPEPTIDE ENKEPHALIN ANALOGS HAVING VARYING N-TERMINAL AMINO-ACIDS, Journal of pharmaceutical sciences, 84(1), 1995, pp. 62-64
SYNTHESIS OF THROMBIN INHIBITOR DUP-714
Authors: WITYAK J EARL RA ABELMAN MM BETHEL YB FISHER BN KAUFFMAN GS KETTNER CA MA P MCMILLAN JL MERSINGER LJ PESTI J PIERCE ME RANKIN FW CHORVAT RJ CONFALONE PN
Citation: J. Wityak et al., SYNTHESIS OF THROMBIN INHIBITOR DUP-714, Journal of organic chemistry, 60(12), 1995, pp. 3717-3722
KINETIC AND CRYSTALLOGRAPHIC STUDIES OF THROMBIN WITH AC-(D)PHE-PRO-BOROARG-OH AND ITS LYSINE, AMIDINE, HOMOLYSINE, AND ORNITHINE ANALOGS
Authors: WEBER PC LEE SL LEWANDOWSKI FA SCHADT MC CHANG CH KETTNER CA
Citation: Pc. Weber et al., KINETIC AND CRYSTALLOGRAPHIC STUDIES OF THROMBIN WITH AC-(D)PHE-PRO-BOROARG-OH AND ITS LYSINE, AMIDINE, HOMOLYSINE, AND ORNITHINE ANALOGS, Biochemistry, 34(11), 1995, pp. 3750-3757
CONVERTING TRYPSIN TO CHYMOTRYPSIN - GROUND-STATE BINDING DOES NOT DETERMINE SUBSTRATE-SPECIFICITY
Authors: HEDSTROM L FARRJONES S KETTNER CA RUTTER WJ
Citation: L. Hedstrom et al., CONVERTING TRYPSIN TO CHYMOTRYPSIN - GROUND-STATE BINDING DOES NOT DETERMINE SUBSTRATE-SPECIFICITY, Biochemistry, 33(29), 1994, pp. 8764-8769
KINLSQ - A PROGRAM FOR FITTING KINETICS DATA WITH NUMERICALLY INTEGRATED RATE-EQUATIONS AND ITS APPLICATION TO THE ANALYSIS OF SLOW, TIGHT-BINDING INHIBITION DATA
Authors: GUTHEIL WG KETTNER CA BACHOVCHIN WW
Citation: Wg. Gutheil et al., KINLSQ - A PROGRAM FOR FITTING KINETICS DATA WITH NUMERICALLY INTEGRATED RATE-EQUATIONS AND ITS APPLICATION TO THE ANALYSIS OF SLOW, TIGHT-BINDING INHIBITION DATA, Analytical biochemistry, 223(1), 1994, pp. 13-20
THE SOLUTION CONFORMATION OF (D)PHE-PRO-CONTAINING PEPTIDES - IMPLICATIONS ON THE ACTIVITY OF AC-(D)PHE-PRO-BOROARG-OH, A POTENT THROMBIN INHIBITOR
Authors: LIM MSL JOHNSTON ER KETTNER CA
Citation: Msl. Lim et al., THE SOLUTION CONFORMATION OF (D)PHE-PRO-CONTAINING PEPTIDES - IMPLICATIONS ON THE ACTIVITY OF AC-(D)PHE-PRO-BOROARG-OH, A POTENT THROMBIN INHIBITOR, Journal of medicinal chemistry, 36(13), 1993, pp. 1831-1838
B-11 NMR-SPECTROSCOPY OF PEPTIDE BORONIC ACID INHIBITOR COMPLEXES OF ALPHA-LYTIC PROTEASE - DIRECT EVIDENCE FOR TETRAHEDRAL BORON IN BOTH BORON HISTIDINE AND BORON SERINE ADDUCT COMPLEXES
Authors: TSILIKOUNAS E KETTNER CA BACHOVCHIN WW
Citation: E. Tsilikounas et al., B-11 NMR-SPECTROSCOPY OF PEPTIDE BORONIC ACID INHIBITOR COMPLEXES OF ALPHA-LYTIC PROTEASE - DIRECT EVIDENCE FOR TETRAHEDRAL BORON IN BOTH BORON HISTIDINE AND BORON SERINE ADDUCT COMPLEXES, Biochemistry, 32(47), 1993, pp. 12651-12655
Risultati: 1-23 |