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Results:
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Results: 23
Authors:
HSIOU Y
DAS KY
DING JP
CLARK AD
KLEIM JP
ROSNER M
WINKLER I
RIESS G
HUGHES SH
ARNOLD E
Citation: Y. Hsiou et al., STRUCTURES OF TYR188LEU MUTANT AND WILD-TYPE HIV-1 REVERSE-TRANSCRIPTASE COMPLEXED WITH THE NONNUCLEOSIDE INHIBITOR HBY-097 - INHIBITOR FLEXIBILITY IS A USEFUL DESIGN FEATURE FOR REDUCING DRUG-RESISTANCE, Journal of Molecular Biology, 284(2), 1998, pp. 313-323
Authors:
BALZARINI J
PELEMANS H
RIESS G
ROESNER M
WINKLER I
DECLERCQ E
KLEIM JP
Citation: J. Balzarini et al., RETENTION OF MARKED SENSITIVITY TO HYLTHIOMETHYL)-3,4-DIHYDROQUINOXALINE-2(1H)-THIONE (HBY-097) BY AN AZIDOTHYMIDINE (AZT)-RESISTANT HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 (HIV-1) STRAIN SUBCULTURED IN THE COMBINED PRESENCE OF QUINOXALINE HBY-097 AND 2',3'-DIDEOXY-3'-THIACYTIDINE (LAMIVUDINE), Biochemical pharmacology, 55(5), 1998, pp. 617-625
Authors:
RUBSAMENWAIGMANN H
HUGUENEL E
PAESSENS A
KLEIM JP
WAINBERG MA
SHAH A
Citation: H. Rubsamenwaigmann et al., 2ND-GENERATION NON-NUCLEOSIDIC REVERSE-TRANSCRIPTASE INHIBITOR HBY097AND HIV-1 VIRAL LOAD, Lancet, 349(9064), 1997, pp. 1517-1517
Authors:
KLEIM JP
WINKLER I
ROSNER M
KIRSCH R
RUBSAMENWAIGMANN H
PAESSENS A
RIESS G
Citation: Jp. Kleim et al., IN-VITRO SELECTION FOR DIFFERENT MUTATIONAL PATTERNS IN THE HIV-1 REVERSE-TRANSCRIPTASE USING HIGH AND LOW SELECTIVE PRESSURE OF THE NONNUCLEOSIDE REVERSE-TRANSCRIPTASE INHIBITOR HBY-097, Virology, 231(1), 1997, pp. 112-118
Authors:
BALZARINI J
PELEMANS H
DECLERCQ E
KARLSSON A
KLEIM JP
Citation: J. Balzarini et al., REVERSE-TRANSCRIPTASE FIDELITY AND HIV-1 VARIATION, Science, 275(5297), 1997, pp. 229-230
Authors:
PELEMANS H
ESNOUF R
DUNKLER A
PARNIAK MA
VANDAMME AM
KARLSSON A
DECLERCQ E
KLEIM JP
BALZARINI J
Citation: H. Pelemans et al., CHARACTERISTICS OF THE PRO225HIS MUTATION IN HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 (HIV-1) REVERSE-TRANSCRIPTASE THAT APPEARS UNDER SELECTIVEPRESSURE OF DOSE-ESCALATING QUINOXALINE TREATMENT OF HIV-1, Journal of virology, 71(11), 1997, pp. 8195-8203
Authors:
BALZARINI J
PELEMANS H
RIESS G
ROESNER M
WINKLER I
DECLERCQ E
KLEIM JP
Citation: J. Balzarini et al., ZIDOVUDINE-RESISTANT HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 STRAINS SUBCULTURED IN THE PRESENCE OF BOTH LAMIVUDINE AND QUINOXALINE HBY-097 RETAIN MARKED SENSITIVITY TO HBY-097 BUT NOT TO LAMIVUDINE, The Journal of infectious diseases, 176(5), 1997, pp. 1392-1397
Authors:
PRINZINGER R
BECKER P
KLEIM JP
SCHROTH W
SCHIERWATER B
Citation: R. Prinzinger et al., THE TAXONOMIC STATUS OF LANIARIUS-DUBIOSUS (RCHW. 1899) WITH ADDITIONAL DATA ON TYPE DESCRIPTION OF LANIARIUS-LIBERATUS, BULO-BURTI-BOUBOU (SMITH, ARCTANDER, FJELDSA AND AMIR 1991), Journal fur Ornithologie, 138(3), 1997, pp. 283-289
Authors:
PRINZINGER R
KLEIM JP
SCHROTH W
SCHIERWATER B
Citation: R. Prinzinger et al., DNA-SEQUENCE ANALYSIS OF MITOCHONDRIAL CYT-B AND THE SPECIES STATUS OF LANIARIUS-DUBIOSUS (RCHW. 1899), Journal fur Ornithologie, 138(3), 1997, pp. 291-296
Authors:
RUBSAMENWAIGMANN H
WAINBERG M
HUGUENEL E
SHAH A
PAESSENS A
KLEIM JP
ROSNER M
Citation: H. Rubsamenwaigmann et al., ANTIVIRAL PROFILE OF HBY-097, A NONNUCLEOSIDIC INHIBITOR OF HIV-1 RT IN A PHASE STUDY, Experimental hematology, 24(9), 1996, pp. 377-377
Authors:
VANDAMME AM
SCHMIT JC
BALZARINI J
WITVROUW M
VANLAETHEM K
KLEIM JP
DESMYTER J
DECLERCQ E
Citation: Am. Vandamme et al., IN-VITRO SELECTION OF HIGH-LEVEL QUINOXALINE (HBY097) RESISTANCE USING A PATIENT ISOLATE DISPLAYING A MULTIDRUG-RESISTANT PHENOTYPE, AIDS, 10, 1996, pp. 5-5
Authors:
RIESS G
WINKLER I
ROSNER M
KIRSCH R
RUBSAMENWAIGMANN H
PAESSENS A
KLEIM JP
HOECHST AG
Citation: G. Riess et al., DIFFERENT MUTATIONAL PATHWAYS OF THE HIV-1 RT GENE ARE DEFINED BY ALTERNATIVE EXPERIMENTAL PROTOCOLS APPLIED TO GENERATE IN-VITRO RESISTANCE OF HIV-1 TO HBY-097, AIDS, 10, 1996, pp. 8-8
Authors:
BALZARINI J
PELEMANS H
KARLSSON A
DECLERCQ E
KLEIM JP
Citation: J. Balzarini et al., CONCOMITANT COMBINATION THERAPY FOR HIV-INFECTION PREFERABLE OVER SEQUENTIAL THERAPY WITH 3TC AND NONNUCLEOSIDE REVERSE-TRANSCRIPTASE INHIBITORS, Proceedings of the National Academy of Sciences of the United Statesof America, 93(23), 1996, pp. 13152-13157
Authors:
KLEIM JP
ROSNER M
WINKLER I
PAESSENS A
KIRSCH R
HSIOU Y
ARNOLD E
RIESS G
Citation: Jp. Kleim et al., SELECTIVE PRESSURE OF A QUINOXALINE NONNUCLEOSIDE INHIBITOR OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 (HIV-1) REVERSE-TRANSCRIPTASE (RT) ON HIV-1 REPLICATION RESULTS IN THE EMERGENCE OF NUCLEOSIDE RT-INHIBITOR-SPECIFIC (RT LEU-74-]VAL OR ILE AND VAL-75-]LEU OR ILE) HIV-1 MUTANTS, Proceedings of the National Academy of Sciences of the United Statesof America, 93(1), 1996, pp. 34-38
Authors:
KLEIM JP
ROSNER M
WINKLER I
PAESSENS A
KIRSCH R
HSIOU Y
ARNOLD E
RIESS G
Citation: Jp. Kleim et al., NUCLEOSIDE REVERSE-TRANSCRIPTASE (RT) INHIBITOR-SPECIFIC MUTATIONS WITHIN THE HIV-1 POL GENE SELECTED WITH A NONNUCLEOSIDE TYPE RT INHIBITOR, Journal of acquired immune deficiency syndromes and human retrovirology, 10, 1995, pp. 3-3
Authors:
ARNOLD E
DAS K
DING JP
HSIOU Y
TANTILLO C
ROY BM
YADAV P
ZHANG WY
LENTZ K
CLARK AD
BOYER PL
HUGHES SH
MITSUYA H
MELLORS J
KLEIM JP
ROSNER M
MOEREELS HR
KOYMANS L
ANDRIES K
PAUWELS R
JANSSEN PAJ
Citation: E. Arnold et al., THE ROLE OF NUCLEIC-ACID IN THE RESISTANCE OF HIV-1 REVERSE-TRANSCRIPTASE TO NUCLEOSIDE AND NONNUCLEOSIDE INHIBITORS, Journal of acquired immune deficiency syndromes and human retrovirology, 10, 1995, pp. 7-7
Authors:
RUBSAMENWAIGMANN H
PAESSENS A
BLUNCK M
KLEIM JP
RIESS G
WINKLER I
ROSNER M
SCHNEWEIS KE
VONBRIESEN H
Citation: H. Rubsamenwaigmann et al., HBY 097, IN-VITRO ANTIVIRAL PROFILE AGAINST HIV-1 AND ACTIVITY IN COMBINATION WITH OTHER ANTI-HIV-DRUGS, AIDS research and human retroviruses, 11, 1995, pp. 159-159
Authors:
KLEIM JP
BENDER R
KIRSCH R
MEICHSNER C
PAESSENS A
ROSNER M
RUBSAMENWAIGMANN H
KAISER R
WICHERS M
SCHNEWEIS KE
WINKLER I
RIESS G
Citation: Jp. Kleim et al., PRECLINICAL EVALUATION OF HBY-097, A NEW NONNUCLEOSIDE REVERSE-TRANSCRIPTASE INHIBITOR OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 REPLICATION, Antimicrobial agents and chemotherapy, 39(10), 1995, pp. 2253-2257
Authors:
KLEIM JP
BENDER R
KIRSCH R
MEICHSNER C
PAESSENS A
RIESS G
Citation: Jp. Kleim et al., MUTATIONAL ANALYSIS OF RESIDUE-190 OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 REVERSE-TRANSCRIPTASE, Virology, 200(2), 1994, pp. 696-701
Authors:
BALZARINI J
KARLSSON A
MEICHSNER C
PAESSENS A
RIESS G
DECLERCQ E
KLEIM JP
Citation: J. Balzarini et al., RESISTANCE PATTERN OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 REVERSE-TRANSCRIPTASE TO QUINOXALINE S-2720, Journal of virology, 68(12), 1994, pp. 7986-7992
Authors:
BALZARINI J
KLEIM JP
RIESS G
CAMARASA MJ
DECLERCQ E
KARLSSON A
Citation: J. Balzarini et al., SENSITIVITY OF (138 GLU-]LYS) MUTATED HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 (HIV-1) REVERSE-TRANSCRIPTASE (RT) TO HIV-1-SPECIFIC RT-INHIBITORS, Biochemical and biophysical research communications, 201(3), 1994, pp. 1305-1312
Authors:
KLEIM JP
BENDER R
BILHARDT UM
MEICHSNER C
PAESSENS A
REISS G
ROSNER M
WINKLER I
Citation: Jp. Kleim et al., A QUINOXALINE DERIVATIVE WITH HIGH INHIBITORY ACTIVITY AGAINST HIV-1 DEFINES A NEW BINDING-SITE ON THE REVERSE-TRANSCRIPTASE, Journal of cellular biochemistry, 1993, pp. 16-16
Authors:
KLEIM JP
BENDER R
BILLHARDT UM
MEICHSNER C
RIESS G
ROSNER M
WINKLER I
PAESSENS A
Citation: Jp. Kleim et al., ACTIVITY OF A NOVEL QUINOXALINE DERIVATIVE AGAINST HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 REVERSE-TRANSCRIPTASE AND VIRAL REPLICATION, Antimicrobial agents and chemotherapy, 37(8), 1993, pp. 1659-1664
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