AAAAAA

   
Results: 1-13 |
Results: 13
STRUCTURE-ACTIVITY STUDIES RELATED TO ABT-594, A POTENT NONOPIOID ANALGESIC AGENT - EFFECT OF PYRIDINE AND AZETIDINE RING SUBSTITUTIONS ON NICOTINIC ACETYLCHOLINE-RECEPTOR BINDING-AFFINITY AND ANALGESIC ACTIVITY IN MICE
Authors: HOLLADAY MW BAI H LI YH LIN NH DAANEN JF RYTHER KB WASICAK JT KINCAID JF HE Y HETTINGER AM HUANG P ANDERSON DJ BANNON AW BUCKLEY MJ CAMPBELL JE DONNELLYROBERTS DL GUNTHER KL KIM DJB KUNTZWEILER TA SULLIVAN JP DECKER MW ARNERIC SP
Citation: Mw. Holladay et al., STRUCTURE-ACTIVITY STUDIES RELATED TO ABT-594, A POTENT NONOPIOID ANALGESIC AGENT - EFFECT OF PYRIDINE AND AZETIDINE RING SUBSTITUTIONS ON NICOTINIC ACETYLCHOLINE-RECEPTOR BINDING-AFFINITY AND ANALGESIC ACTIVITY IN MICE, Bioorganic & medicinal chemistry letters, 8(19), 1998, pp. 2797-2802
THE ROLE OF NEURONAL NICOTINIC ACETYLCHOLINE-RECEPTORS IN ANTINOCICEPTION - EFFECTS OF ABT-594
Authors: DECKER MW CURZON P HOLLADAY MW NIKKEL AL BITNER RS BANNON AW DONNELLYROBERTS DL PUTTFARCKEN PS KUNTZWEILER TA BRIGGS CA WILLIAMS M ARNERIC SP
Citation: Mw. Decker et al., THE ROLE OF NEURONAL NICOTINIC ACETYLCHOLINE-RECEPTORS IN ANTINOCICEPTION - EFFECTS OF ABT-594, J PHYSL-PAR, 92(3-4), 1998, pp. 221-224
RAPID ASSESSMENT OF LIGAND ACTIONS WITH NICOTINIC ACETYLCHOLINE-RECEPTORS USING CALCIUM DYNAMICS AND FLIPR
Authors: KUNTZWEILER TA ARNERIC SP DONNELLYROBERTS DL
Citation: Ta. Kuntzweiler et al., RAPID ASSESSMENT OF LIGAND ACTIONS WITH NICOTINIC ACETYLCHOLINE-RECEPTORS USING CALCIUM DYNAMICS AND FLIPR, Drug development research, 44(1), 1998, pp. 14-20
ABT-594 [(R)-5-(2-AZETIDINYLMETHOXY)-2-CHLOROPYRIDINE] - A NOVEL, ORALLY EFFECTIVE ANALGESIC ACTING VIA NEURONAL NICOTINIC ACETYLCHOLINE-RECEPTORS - I - IN-VITRO CHARACTERIZATION
Authors: DONNELLYROBERTS DL PUTTFARCKEN PS KUNTZWEILER TA BRIGGS CA ANDERSON DJ CAMPBELL JE PIATTONIKAPLAN M MCKENNA DG WASICAK JT HOLLADAY MW WILLIAMS M ARNERIC SP
Citation: Dl. Donnellyroberts et al., ABT-594 [(R)-5-(2-AZETIDINYLMETHOXY)-2-CHLOROPYRIDINE] - A NOVEL, ORALLY EFFECTIVE ANALGESIC ACTING VIA NEURONAL NICOTINIC ACETYLCHOLINE-RECEPTORS - I - IN-VITRO CHARACTERIZATION, The Journal of pharmacology and experimental therapeutics, 285(2), 1998, pp. 777-786
MONOSUBSTITUTED-3,8-DIAZABICYCLO[3.2.1]OCTANE AND DISUBSTITUTED-3,8-DIAZABICYCLO[3.2.1]OCTANE DERIVATIVES AS ANALGESICS STRUCTURALLY RELATED TO EPIBATIDINE - SYNTHESIS, ACTIVITY, AND MODELING
Authors: BARLOCCO D CIGNARELLA G TONDI D VIANELLO P VILLA S BARTOLINI A GHELARDINI C GALEOTTI N ANDERSON DJ KUNTZWEILER TA COLOMBO D TOMA L
Citation: D. Barlocco et al., MONOSUBSTITUTED-3,8-DIAZABICYCLO[3.2.1]OCTANE AND DISUBSTITUTED-3,8-DIAZABICYCLO[3.2.1]OCTANE DERIVATIVES AS ANALGESICS STRUCTURALLY RELATED TO EPIBATIDINE - SYNTHESIS, ACTIVITY, AND MODELING, Journal of medicinal chemistry, 41(5), 1998, pp. 674-681
IDENTIFICATION AND INITIAL STRUCTURE-ACTIVITY-RELATIONSHIPS OF 5-(2-AZETIDINYLMETHOXY)-2-CHLOROPYRIDINE(ABT-594), A POTENT, ORALLY-ACTIVE, NONOPIATE ANALGESIC AGENT ACTING VIA NEURONAL NICOTINIC ACETYLCHOLINE-RECEPTORS
Authors: HOLLADAY MW WASICAK JT LIN NH HE Y RYTHER KB BANNON AW BUCKLEY MJ KIM DJB DECKER MW ANDERSON DJ CAMPBELL JE KUNTZWEILER TA DONNELLYROBERTS DL PIATTONIKAPLAN M BRIGGS CA WILLIAMS M ARNERIC SP
Citation: Mw. Holladay et al., IDENTIFICATION AND INITIAL STRUCTURE-ACTIVITY-RELATIONSHIPS OF 5-(2-AZETIDINYLMETHOXY)-2-CHLOROPYRIDINE(ABT-594), A POTENT, ORALLY-ACTIVE, NONOPIATE ANALGESIC AGENT ACTING VIA NEURONAL NICOTINIC ACETYLCHOLINE-RECEPTORS, Journal of medicinal chemistry, 41(4), 1998, pp. 407-412
NOVEL 2-(2'-FURO[3,2-B]PYRIDINYL) PYRROLIDINES - POTENT NEURONAL NICOTINIC ACETYLCHOLINE-RECEPTOR LIGANDS
Authors: ELLIOTT RL RYTHER KB ANDERSON DJ PIATTONIKAPLAN M KUNTZWEILER TA DONNELLYROBERTS D ARNERIC SP HOLLADAY MW
Citation: Rl. Elliott et al., NOVEL 2-(2'-FURO[3,2-B]PYRIDINYL) PYRROLIDINES - POTENT NEURONAL NICOTINIC ACETYLCHOLINE-RECEPTOR LIGANDS, Bioorganic & medicinal chemistry letters, 7(21), 1997, pp. 2703-2708
AMINO-ACID SUBSTITUTIONS IN THE RAT NA-ATPASE ALPHA-2-SUBUNIT ALTER THE CATION REGULATION OF PUMP CURRENT EXPRESSED IN HELA-CELLS(,K+)
Authors: YAMAMOTO S KUNTZWEILER TA WALLICK ET SPERELAKIS N YATANI A
Citation: S. Yamamoto et al., AMINO-ACID SUBSTITUTIONS IN THE RAT NA-ATPASE ALPHA-2-SUBUNIT ALTER THE CATION REGULATION OF PUMP CURRENT EXPRESSED IN HELA-CELLS(,K+), Journal of physiology, 495(3), 1996, pp. 733-742
ASP(804) AND ASP(808) IN THE TRANSMEMBRANE DOMAIN OF THE NA,K-ATPASE ALPHA-SUBUNIT ARE CATION COORDINATING RESIDUES
Authors: KUNTZWEILER TA ARGUELLO JM LINGREL JB
Citation: Ta. Kuntzweiler et al., ASP(804) AND ASP(808) IN THE TRANSMEMBRANE DOMAIN OF THE NA,K-ATPASE ALPHA-SUBUNIT ARE CATION COORDINATING RESIDUES, The Journal of biological chemistry, 271(47), 1996, pp. 29682-29687
CRITICAL EFFECTS ON CATALYTIC FUNCTION PRODUCED BY AMINO-ACID SUBSTITUTIONS AT ASP(804) AND ASP(808) OF THE ALPHA-1 ISOFORM OF NA,K-ATPASE
Authors: VANHUYSSE JW KUNTZWEILER TA LINGREL JB
Citation: Jw. Vanhuysse et al., CRITICAL EFFECTS ON CATALYTIC FUNCTION PRODUCED BY AMINO-ACID SUBSTITUTIONS AT ASP(804) AND ASP(808) OF THE ALPHA-1 ISOFORM OF NA,K-ATPASE, FEBS letters, 389(2), 1996, pp. 179-185
GLUTAMIC-ACID-327 IN THE SHEEP ALPHA-1 ISOFORM OF NA-ATPASE IS A PIVOTAL RESIDUE FOR CATION-INDUCED CONFORMATIONAL-CHANGES(,K+)
Authors: JOHNSON CL KUNTZWEILER TA LINGREL JB JOHNSON CG WALLICK ET
Citation: Cl. Johnson et al., GLUTAMIC-ACID-327 IN THE SHEEP ALPHA-1 ISOFORM OF NA-ATPASE IS A PIVOTAL RESIDUE FOR CATION-INDUCED CONFORMATIONAL-CHANGES(,K+), Biochemical journal, 309, 1995, pp. 187-194
GLUTAMIC-ACID-327 IN THE SHEEP ALPHA-1 ISOFORM OF NA-ATPASE STABILIZES A K+-INDUCED CONFORMATIONAL CHANGE(,K+)
Authors: KUNTZWEILER TA WALLICK ET JOHNSON CL LINGREL JB
Citation: Ta. Kuntzweiler et al., GLUTAMIC-ACID-327 IN THE SHEEP ALPHA-1 ISOFORM OF NA-ATPASE STABILIZES A K+-INDUCED CONFORMATIONAL CHANGE(,K+), The Journal of biological chemistry, 270(7), 1995, pp. 2993-3000
AMINO-ACID REPLACEMENT OF ASP(369) IN THE SHEEP ALPHA-1 ISOFORM ELIMINATES ATP AND PHOSPHATE STIMULATION OF [H-3] OUABAIN BINDING TO THE NA-ATPASE WITHOUT ALTERING THE CATION-BINDING PROPERTIES OF THE ENZYME(,K+)
Authors: KUNTZWEILER TA WALLICK ET JOHNSON CL LINGREL JB
Citation: Ta. Kuntzweiler et al., AMINO-ACID REPLACEMENT OF ASP(369) IN THE SHEEP ALPHA-1 ISOFORM ELIMINATES ATP AND PHOSPHATE STIMULATION OF [H-3] OUABAIN BINDING TO THE NA-ATPASE WITHOUT ALTERING THE CATION-BINDING PROPERTIES OF THE ENZYME(,K+), The Journal of biological chemistry, 270(27), 1995, pp. 16206-16212
Risultati: 1-13 |