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Results: 1-25 | 26-50 | 51-58
Results: 1-25/58
Farnesyl transferase inhibitors - a novel therapy for breast cancer
Authors: Johnston, SRD Kelland, LR
Citation: Srd. Johnston et Lr. Kelland, Farnesyl transferase inhibitors - a novel therapy for breast cancer, ENDOCR-R CA, 8(3), 2001, pp. 227-235
Preclinical antitumor activity and pharmacodynamic studies with the farnesylprotein transferase inhibitor R115777 in human breast cancer
Authors: Kelland, LR Smith, V Valenti, M Patterson, L Clarke, PA Detre, S End, D Howes, AJ Dowsett, M Workman, P Johnston, SRD
Citation: Lr. Kelland et al., Preclinical antitumor activity and pharmacodynamic studies with the farnesylprotein transferase inhibitor R115777 in human breast cancer, CLIN CANC R, 7(11), 2001, pp. 3544-3550
In vitro prevention of the emergence of multidrug resistance in a pediatric rhabdomyosarcoma cell line
Authors: Cocker, HA Tiffin, N Pritchard-Jones, K Pinkerton, CR Kelland, LR
Citation: Ha. Cocker et al., In vitro prevention of the emergence of multidrug resistance in a pediatric rhabdomyosarcoma cell line, CLIN CANC R, 7(10), 2001, pp. 3193-3198
Synthesis of the first example of a C2-C3/C2 '-C3 '-endo unsaturated pyrrolo[2,1-c][1,4]benzodiazepine dimer
Authors: Gregson, SJ Howard, PW Corcoran, KE Jenkins, TC Kelland, LR Thurston, DE
Citation: Sj. Gregson et al., Synthesis of the first example of a C2-C3/C2 '-C3 '-endo unsaturated pyrrolo[2,1-c][1,4]benzodiazepine dimer, BIOORG MED, 11(21), 2001, pp. 2859-2862
Synthesis and antitumour activity of platinum(II) and platinum(IV) complexes containing ethylenediamine-derived ligands having alcohol, carboxylic acid and acetate substituents - Crystal and molecular structure of [(PtLCl2)-Cl-4]center dot H2O where L-4 is ethylenediamine-N,N '-diacetate
Authors: Jolley, JN Yanovsky, AI Kelland, LR Nolan, KB
Citation: Jn. Jolley et al., Synthesis and antitumour activity of platinum(II) and platinum(IV) complexes containing ethylenediamine-derived ligands having alcohol, carboxylic acid and acetate substituents - Crystal and molecular structure of [(PtLCl2)-Cl-4]center dot H2O where L-4 is ethylenediamine-N,N '-diacetate, J INORG BIO, 83(2-3), 2001, pp. 91-100
Structure-based design of selective and potent G quadruplex-mediated telomerase inhibitors
Authors: Read, M Harrison, RJ Romagnoli, B Tanious, FA Gowan, SH Reszka, AP Wilson, WD Kelland, LR Neidle, S
Citation: M. Read et al., Structure-based design of selective and potent G quadruplex-mediated telomerase inhibitors, P NAS US, 98(9), 2001, pp. 4844-4849
Short tandem repeat profiling provides an international reference standardfor human cell lines
Authors: Masters, JR Thomson, JA Daly-Burns, B Reid, YA Dirks, WG Packer, P Toji, LH Ohno, T Tanabe, H Arlett, CF Kelland, LR Harrison, M Virmani, A Ward, TH Ayres, KL Debenham, PG
Citation: Jr. Masters et al., Short tandem repeat profiling provides an international reference standardfor human cell lines, P NAS US, 98(14), 2001, pp. 8012-8017
Characterization of a human colorectal carcinoma cell line with acquired resistance to flavopiridol
Authors: Smith, V Raynaud, F Workman, P Kelland, LR
Citation: V. Smith et al., Characterization of a human colorectal carcinoma cell line with acquired resistance to flavopiridol, MOLEC PHARM, 60(5), 2001, pp. 885-893
Potent inhibition of telomerase by small-molecule pentacyclic acridines capable of interacting with G-quadruplexes
Authors: Gowan, SM Heald, R Stevens, MFG Kelland, LR
Citation: Sm. Gowan et al., Potent inhibition of telomerase by small-molecule pentacyclic acridines capable of interacting with G-quadruplexes, MOLEC PHARM, 60(5), 2001, pp. 981-988
Design, synthesis, and evaluation of a novel pyrrolobenzodiazepine DNA-interactive agent with highly efficient cross-linking ability and potent cytotoxicity
Authors: Gregson, SJ Howard, PW Hartley, JA Brooks, NA Adams, LJ Jenkins, TC Kelland, LR Thurston, DE
Citation: Sj. Gregson et al., Design, synthesis, and evaluation of a novel pyrrolobenzodiazepine DNA-interactive agent with highly efficient cross-linking ability and potent cytotoxicity, J MED CHEM, 44(5), 2001, pp. 737-748
A new class of symmetric bisbenzimidazole-based DNA minor groove-binding agents showing antitumor activity
Authors: Mann, J Baron, A Opoku-Boahen, Y Johansson, E Parkinson, G Kelland, LR Neidle, S
Citation: J. Mann et al., A new class of symmetric bisbenzimidazole-based DNA minor groove-binding agents showing antitumor activity, J MED CHEM, 44(2), 2001, pp. 138-144
Novel approaches to polynuclear platinum pro-drugs. Selective release of cytotoxic platinum spermidine species through hydrolytic cleavage of carbamates
Authors: Hegmans, A Qu, Y Kelland, LR Roberts, JD Farrell, N
Citation: A. Hegmans et al., Novel approaches to polynuclear platinum pro-drugs. Selective release of cytotoxic platinum spermidine species through hydrolytic cleavage of carbamates, INORG CHEM, 40(24), 2001, pp. 6108-6114
Synthesis, cytotoxicity and DNA cross-linking activity of symmetrical dimers based upon the epoxide domain of the azinomycins
Authors: Hartley, JA Hazrati, A Hodgkinson, TJ Kelland, LR Khanim, R Shipman, M Suzenet, F
Citation: Ja. Hartley et al., Synthesis, cytotoxicity and DNA cross-linking activity of symmetrical dimers based upon the epoxide domain of the azinomycins, PHYS CHEM P, 2(23), 2000, pp. 2325-2326
A synthetic azinomycin analogue with demonstrated DNA cross-linking activity: Insights into the mechanism of action of this class of antitumor agent
Authors: Hartley, JA Hazrati, A Kelland, LR Khanim, R Shipman, M Suzenet, F Walker, LF
Citation: Ja. Hartley et al., A synthetic azinomycin analogue with demonstrated DNA cross-linking activity: Insights into the mechanism of action of this class of antitumor agent, ANGEW CHEM, 39(19), 2000, pp. 3467
A new resistance mechanism to cisplatin?
Authors: Kelland, LR
Citation: Lr. Kelland, A new resistance mechanism to cisplatin?, DRUG RESIST, 3(3), 2000, pp. 139-141
Synthesis, cytotoxicity and DNA cross-linking activity of symmetrical dimers based upon the epoxide domain of the azinomycins
Authors: Hartley, JA Hazrati, A Hodgkinson, TJ Kelland, LR Khanim, R Shipman, M Suzenet, F
Citation: Ja. Hartley et al., Synthesis, cytotoxicity and DNA cross-linking activity of symmetrical dimers based upon the epoxide domain of the azinomycins, CHEM COMMUN, (23), 2000, pp. 2325-2326
An update on satraplatin: the first orally available platinum anticancer drug
Authors: Kelland, LR
Citation: Lr. Kelland, An update on satraplatin: the first orally available platinum anticancer drug, EXPERT OP I, 9(6), 2000, pp. 1373-1382
Flavopiridol, the first cyclin-dependent kinase inhibitor to enter the clinic: current status
Authors: Kelland, LR
Citation: Lr. Kelland, Flavopiridol, the first cyclin-dependent kinase inhibitor to enter the clinic: current status, EXPERT OP I, 9(12), 2000, pp. 2903-2911
BBR 3464: A novel triplatinum complex, exhibiting a preclinical profile ofantitumor efficacy different from cisplatin
Authors: Manzotti, C Pratesi, G Menta, E Di Domenico, R Cavalletti, E Fiebig, HH Kelland, LR Farrell, N Polizzi, D Supino, R Pezzoni, G Zunino, F
Citation: C. Manzotti et al., BBR 3464: A novel triplatinum complex, exhibiting a preclinical profile ofantitumor efficacy different from cisplatin, CLIN CANC R, 6(7), 2000, pp. 2626-2634
Chemical synthesis and cytotoxicity of some azinomycin analogues devoid ofthe 1-azabicyclo[3.1.0]hexane subunit
Authors: Hodgkinson, TJ Kelland, LR Shipman, M Suzenet, F
Citation: Tj. Hodgkinson et al., Chemical synthesis and cytotoxicity of some azinomycin analogues devoid ofthe 1-azabicyclo[3.1.0]hexane subunit, BIOORG MED, 10(3), 2000, pp. 239-241
Effect of C2-exo unsaturation on the cytotoxicity and DNA-binding reactivity of pyrrolo[2,1-c][1,4]benzodiazepines
Authors: Gregson, SJ Howard, PW Corcoran, KE Barcella, S Yasin, MM Hurst, AA Jenkins, TC Kelland, LR Thurston, DE
Citation: Sj. Gregson et al., Effect of C2-exo unsaturation on the cytotoxicity and DNA-binding reactivity of pyrrolo[2,1-c][1,4]benzodiazepines, BIOORG MED, 10(16), 2000, pp. 1845-1847
Effect of C2/C3-endo unsaturation on the cytotoxicity and DNA-binding reactivity of pyrrolo[2,1-c][1,4]benzodiazepines
Authors: Gregson, SJ Howard, PW Barcella, S Nakamya, A Jenkins, TC Kelland, LR Thurston, DE
Citation: Sj. Gregson et al., Effect of C2/C3-endo unsaturation on the cytotoxicity and DNA-binding reactivity of pyrrolo[2,1-c][1,4]benzodiazepines, BIOORG MED, 10(16), 2000, pp. 1849-1851
Mechanisms of drug resistance to the platinum complex ZD0473 in ovarian cancer cell lines
Authors: Holford, J Beale, PJ Boxall, FE Sharp, SY Kelland, LR
Citation: J. Holford et al., Mechanisms of drug resistance to the platinum complex ZD0473 in ovarian cancer cell lines, EUR J CANC, 36(15), 2000, pp. 1984-1990
Telomerase inhibitors: targeting the vulnerable end of cancer?
Authors: Kelland, LR
Citation: Lr. Kelland, Telomerase inhibitors: targeting the vulnerable end of cancer?, ANTI-CANC D, 11(7), 2000, pp. 503-513
Induction of apoptosis by a novel copper-based anticancer compound, casiopeina II, in L1210 murine leukaemia and CH1 human ovarian carcinoma cells
Authors: De Vizcaya-Ruiz, A Rivero-Muller, A Ruiz-Ramirez, L Kass, GEN Kelland, LR Orr, RM Dobrota, M
Citation: A. De Vizcaya-ruiz et al., Induction of apoptosis by a novel copper-based anticancer compound, casiopeina II, in L1210 murine leukaemia and CH1 human ovarian carcinoma cells, TOX VITRO, 14(1), 2000, pp. 1-5
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