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Results: 1-9 |
Results: 9
Synthesis, antifolate, and antitumor activities of classical and nonclassical 2-amino-4-oxo-5-substituted-pyrrolo[2,3-d]pyrimidines
Authors: Gangjee, A Vidwans, A Elzein, E McGuire, JJ Queener, SF Kisliuk, RL
Citation: A. Gangjee et al., Synthesis, antifolate, and antitumor activities of classical and nonclassical 2-amino-4-oxo-5-substituted-pyrrolo[2,3-d]pyrimidines, J MED CHEM, 44(12), 2001, pp. 1993-2003
Synthesis of novel, nonclassical 2-amino-4-oxo-6(arylthio)ethylpyrrolo[2,3-d]pyrimidines as potential inhibitors of thymidylate synthase
Authors: Gangjee, A Dubash, NP Kisliuk, RL
Citation: A. Gangjee et al., Synthesis of novel, nonclassical 2-amino-4-oxo-6(arylthio)ethylpyrrolo[2,3-d]pyrimidines as potential inhibitors of thymidylate synthase, J HETERO CH, 38(2), 2001, pp. 349-354
Synergistic interactions among antifolates
Authors: Kisliuk, RL
Citation: Rl. Kisliuk, Synergistic interactions among antifolates, PHARM THERA, 85(3), 2000, pp. 183-190
Design, synthesis, and X-ray crystal structure of a potent dual inhibitor of thymidylate synthase and dihydrofolate reductase as an antitumor agent
Authors: Gangjee, A Yu, JM McGuire, JJ Cody, V Galitsky, N Kisliuk, RL Queener, SF
Citation: A. Gangjee et al., Design, synthesis, and X-ray crystal structure of a potent dual inhibitor of thymidylate synthase and dihydrofolate reductase as an antitumor agent, J MED CHEM, 43(21), 2000, pp. 3837-3851
Effect of C9-methyl substitution and C8-C9 conformational restriction on antifolate and antitumor activity of classical 5-substituted 2,4-diaminofuro[2,3-d] pyrimidines
Authors: Gangjee, A Zeng, YB McGuire, JJ Kisliuk, RL
Citation: A. Gangjee et al., Effect of C9-methyl substitution and C8-C9 conformational restriction on antifolate and antitumor activity of classical 5-substituted 2,4-diaminofuro[2,3-d] pyrimidines, J MED CHEM, 43(16), 2000, pp. 3125-3133
The synthesis of novel nonclassical reversed bridge quinazoline antifolates as inhibitors of thymidylate synthase [1a,b]
Authors: Gangjee, A Kothare, M Kisliuk, RL
Citation: A. Gangjee et al., The synthesis of novel nonclassical reversed bridge quinazoline antifolates as inhibitors of thymidylate synthase [1a,b], J HETERO CH, 37(5), 2000, pp. 1097-1102
Metabolism blocked classical folate analog inhibitors of dihydrofolate reductase-1: Synthesis and biological evaluation of mobiletrex
Authors: Nair, MG Fayard, ML Lariccia, JM Amato, AE McGuire, JJ Galivan, JH Kisliuk, RL
Citation: Mg. Nair et al., Metabolism blocked classical folate analog inhibitors of dihydrofolate reductase-1: Synthesis and biological evaluation of mobiletrex, MED CHEM RE, 9(3), 1999, pp. 176-185
Synthesis of classical and a nonclassical 2-amino-4-oxo-6-methyl-5-substituted pyrrolo[2,3-d]pyrimidine antifolate inhibitors of thymidylate synthase
Authors: Gangjee, A Mavandadi, F Kisliuk, RL Queener, SF
Citation: A. Gangjee et al., Synthesis of classical and a nonclassical 2-amino-4-oxo-6-methyl-5-substituted pyrrolo[2,3-d]pyrimidine antifolate inhibitors of thymidylate synthase, J MED CHEM, 42(12), 1999, pp. 2272-2279
Folate biochemistry in relation to antifolate selectivity
Authors: Kisliuk, RL
Citation: Rl. Kisliuk, Folate biochemistry in relation to antifolate selectivity, CANC DRUG, 1999, pp. 13-36
Risultati: 1-9 |