Authors:
Takeuchi, K
Kohn, TJ
Harper, RW
Lin, HS
Gifford-Moore, DS
Richett, ME
Sall, DJ
Smith, GF
Zhang, MS
Citation: K. Takeuchi et al., Diamino benzo[b]thiophene derivatives as a novel class of active site directed thrombin inhibitors. Part 6: Further focus on the contracted C4 '-sidechain analogues, BIOORG MED, 10(11), 2000, pp. 1199-1202
Authors:
Sall, DJ
Bailey, DL
Bastian, JA
Buben, JA
Chirgadze, NY
Clemens-Smith, AC
Denney, ML
Fisher, MJ
Giera, DD
Gifford-Moore, DS
Harper, RW
Johnson, LM
Klimkowski, VJ
Kohn, TJ
Lin, HS
McCowan, JR
Palkowitz, AD
Richett, ME
Smith, GF
Snyder, DW
Takeuchi, K
Toth, JE
Zhang, MS
Citation: Dj. Sall et al., Diamino benzo[b]thiophene derivatives as a novel class of active site directed thrombin inhibitors. 5. Potency, efficacy, and pharmacokinetic properties of modified C-3 side chain derivatives, J MED CHEM, 43(4), 2000, pp. 649-663
Authors:
Takeuchi, K
Kohn, TJ
Sall, DJ
Denney, ML
McCowan, JR
Smith, GF
Gifford-Moore, DS
Citation: K. Takeuchi et al., Dibasic benzo[b]thiophene derivatives as a novel class of active site directed thrombin inhibitors: 4. SAR studies on the conformationally restrictedC3-side chain of hydroxybenzo[b]thiophenes, BIOORG MED, 9(5), 1999, pp. 759-764
Authors:
Zhang, MS
Bailey, DL
Bastian, JA
Briggs, SL
Chirgadze, NY
Clawson, DK
Denney, ML
Gifford-Moore, DS
Harper, RW
Johnson, LM
Klimkowski, VJ
Kohn, TJ
Lin, HS
McCowan, JR
Richett, ME
Sall, DJ
Smith, AJ
Smith, GF
Snyder, DW
Takeuchi, K
Utterback, BG
Yan, SCB
Citation: Ms. Zhang et al., Dibasic benzo[b]thiophene derivatives as a novel class of active site directed thrombin inhibitors: 2. Sidechain optimization and demonstration of invivo efficacy, BIOORG MED, 9(5), 1999, pp. 775-780
Authors:
Takeuchi, K
Kohn, TJ
True, TA
Mais, DE
Wikel, JH
Utterback, BG
Wyss, VL
Jakubowski, JA
Citation: K. Takeuchi et al., Development of dual-acting agents for thromboxane receptor antagonism and thromboxane synthase inhibition. 3. Synthesis and biological activities of oxazolecarboxamide-substituted omega-phenyl-omega-(3-pyridyl)alkenoic acid derivatives and related compounds, J MED CHEM, 41(27), 1998, pp. 5362-5374