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Results: 1-25 | 26-28
Results: 1-25/28
QUANTITATIVE STRUCTURE-ACTIVITY-RELATIONSHIPS ON 5-SUBSTITUTED TERBENZIMIDAZOLES AS TOPOISOMERASE-I POISONS AND ANTITUMOR AGENTS
Authors: KIM JS SUN Q YU C LIU A LIU LF LAVOIE EJ
Citation: Js. Kim et al., QUANTITATIVE STRUCTURE-ACTIVITY-RELATIONSHIPS ON 5-SUBSTITUTED TERBENZIMIDAZOLES AS TOPOISOMERASE-I POISONS AND ANTITUMOR AGENTS, Bioorganic & medicinal chemistry, 6(2), 1998, pp. 163-172
ORIGIN OF THE ANTICANCER ACTIVITY OF TOPOISOMERASE INHIBITORS
Authors: LIU LF DESAI SD SIM SP PILCH DS LI TK LAVOIE EJ SANDERS M DARPA P WANG H WU JX LIU A YU C
Citation: Lf. Liu et al., ORIGIN OF THE ANTICANCER ACTIVITY OF TOPOISOMERASE INHIBITORS, Annals of oncology, 9, 1998, pp. 40-40
DNA MINOR-GROOVE BINDING-DIRECTED POISONING OF HUMAN DNA TOPOISOMERASE-I BY TERBENZIMIDAZOLES
Authors: XU ZT LI TK KIM JS LAVOIE EJ BRESLAUER KJ LIU LF PILCH DS
Citation: Zt. Xu et al., DNA MINOR-GROOVE BINDING-DIRECTED POISONING OF HUMAN DNA TOPOISOMERASE-I BY TERBENZIMIDAZOLES, Biochemistry, 37(10), 1998, pp. 3558-3566
SELECTIVE CYTOTOXICITY OF TOPOISOMERASE-DIRECTED PROTOBERBERINES AGAINST GLIOBLASTOMA CELLS
Authors: SANDERS MM LIU AA LI TK WU HY DESAI SD MAO Y RUBIN EH LAVOIE EJ MAKHEY D LIU LF
Citation: Mm. Sanders et al., SELECTIVE CYTOTOXICITY OF TOPOISOMERASE-DIRECTED PROTOBERBERINES AGAINST GLIOBLASTOMA CELLS, Biochemical pharmacology, 56(9), 1998, pp. 1157-1166
INHIBITORY EFFECT OF ALKYLATING MODULATORS ON THE FUNCTION OF P-GLYCOPROTEIN
Authors: YANG JM SULLIVAN GF MAKHEY DB LAVOIE EJ HAIT WN
Citation: Jm. Yang et al., INHIBITORY EFFECT OF ALKYLATING MODULATORS ON THE FUNCTION OF P-GLYCOPROTEIN, Oncology research, 9(9), 1997, pp. 477-484
A TERBENZIMIDAZOLE THAT PREFERENTIALLY BINDS AND CONFORMATIONALLY ALTERS STRUCTURALLY DISTINCT DNA DUPLEX DOMAINS - A POTENTIAL MECHANISM FOR TOPOISOMERASE-I POISONING
Authors: PILCH DS XU ZT SUN Q LAVOIE EJ LIU LF BRESLAUER KJ
Citation: Ds. Pilch et al., A TERBENZIMIDAZOLE THAT PREFERENTIALLY BINDS AND CONFORMATIONALLY ALTERS STRUCTURALLY DISTINCT DNA DUPLEX DOMAINS - A POTENTIAL MECHANISM FOR TOPOISOMERASE-I POISONING, Proceedings of the National Academy of Sciences of the United Statesof America, 94(25), 1997, pp. 13565-13570
TERBENZIMIDAZOLES - INFLUENCE OF 2''-SUBSTITUENT, 4-SUBSTITUENT, AND 5-SUBSTITUENT ON CYTOTOXICITY AND RELATIVE POTENCY AS TOPOISOMERASE-I POISONS
Authors: KIM JS YU C LIU A LIU LF LAVOIE EJ
Citation: Js. Kim et al., TERBENZIMIDAZOLES - INFLUENCE OF 2''-SUBSTITUENT, 4-SUBSTITUENT, AND 5-SUBSTITUENT ON CYTOTOXICITY AND RELATIVE POTENCY AS TOPOISOMERASE-I POISONS, Journal of medicinal chemistry, 40(18), 1997, pp. 2818-2824
DIFFERENTIAL POISONING OF TOPOISOMERASES BY MENOGARIL AND NOGALAMYCINDICTATED BY THE MINOR GROOVE-BINDING NOGALOSE SUGAR
Authors: SIM SP GATTO B YU C LIU AA LI TK PILCH DS LAVOIE EJ LIU LF
Citation: Sp. Sim et al., DIFFERENTIAL POISONING OF TOPOISOMERASES BY MENOGARIL AND NOGALAMYCINDICTATED BY THE MINOR GROOVE-BINDING NOGALOSE SUGAR, Biochemistry, 36(43), 1997, pp. 13285-13291
MINOR GROOVE-DIRECTED AND INTERCALATIVE LIGAND-DNA INTERACTIONS IN THE POISONING OF HUMAN DNA TOPOISOMERASE-I BY PROTOBERBERINE ANALOGS
Authors: PILCH DS YU C MAKHEY D LAVOIE EJ SRINIVASAN AR OLSON WK SAUERS RR BRESLAUER KJ GEACINTOV NE LIU LF
Citation: Ds. Pilch et al., MINOR GROOVE-DIRECTED AND INTERCALATIVE LIGAND-DNA INTERACTIONS IN THE POISONING OF HUMAN DNA TOPOISOMERASE-I BY PROTOBERBERINE ANALOGS, Biochemistry, 36(41), 1997, pp. 12542-12553
DIFFERENTIAL POISONING OF HUMAN AND ASPERGILLUS-NIDULANS DNA TOPOISOMERASE-I BY BI-BENZIMIDAZOLE AND TERBENZIMIDAZOLE
Authors: GOLDMAN GH YU C WU HY SANDERS MM LAVOIE EJ LIU LF
Citation: Gh. Goldman et al., DIFFERENTIAL POISONING OF HUMAN AND ASPERGILLUS-NIDULANS DNA TOPOISOMERASE-I BY BI-BENZIMIDAZOLE AND TERBENZIMIDAZOLE, Biochemistry, 36(21), 1997, pp. 6488-6494
SYNTHESIS OF BENZIMIDAZO[2,1-ALPHA]ISOQUINOLINES AND 5,6-DIHYDROBENZIMIDAZO[2,1-ALPHA]ISOQUINOLINES
Authors: SUN Q LAVOIE EJ
Citation: Q. Sun et Ej. Lavoie, SYNTHESIS OF BENZIMIDAZO[2,1-ALPHA]ISOQUINOLINES AND 5,6-DIHYDROBENZIMIDAZO[2,1-ALPHA]ISOQUINOLINES, Heterocycles, 43(4), 1996, pp. 737-743
MAMMARY CARCINOGENICITY OF DIOL EPOXIDE METABOLITES OF BENZO[J]FLUORANTHENE IN FEMALE CD RATS
Authors: HECHT SS RIVENSON A AMIN S KRZEMINSKI J ELBAYOUMY K REDDY BS KURTZKE C LAVOIE EJ
Citation: Ss. Hecht et al., MAMMARY CARCINOGENICITY OF DIOL EPOXIDE METABOLITES OF BENZO[J]FLUORANTHENE IN FEMALE CD RATS, Cancer letters, 106(2), 1996, pp. 251-255
THE ROLE OF ACETYLATION IN THE MUTAGENICITY OF THE ANTITUMOR AGENT, BATRACYLIN
Authors: STEVENS GJ LAVOIE EJ MCQUEEN CA
Citation: Gj. Stevens et al., THE ROLE OF ACETYLATION IN THE MUTAGENICITY OF THE ANTITUMOR AGENT, BATRACYLIN, Carcinogenesis, 17(1), 1996, pp. 115-119
SUBSTITUTED 2,5'-BI-1H-BENZIMIDAZOLES - TOPOISOMERASE-I INHIBITION AND CYTOTOXICITY
Authors: KIM JS GATTO B YU C LIU A LIU LF LAVOIE EJ
Citation: Js. Kim et al., SUBSTITUTED 2,5'-BI-1H-BENZIMIDAZOLES - TOPOISOMERASE-I INHIBITION AND CYTOTOXICITY, Journal of medicinal chemistry, 39(4), 1996, pp. 992-998
BIOISOSTERISM - A RATIONAL APPROACH IN DRUG DESIGN
Authors: PATANI GA LAVOIE EJ
Citation: Ga. Patani et Ej. Lavoie, BIOISOSTERISM - A RATIONAL APPROACH IN DRUG DESIGN, Chemical reviews, 96(8), 1996, pp. 3147-3176
IDENTIFICATION OF TOPOISOMERASE-I AS THE CYTOTOXIC TARGET OF THE PROTOBERBERINE ALKALOID CORALYNE
Authors: GATTO B SANDERS MM YU C WU HY MAKHEY D LAVOIE EJ LIU LF
Citation: B. Gatto et al., IDENTIFICATION OF TOPOISOMERASE-I AS THE CYTOTOXIC TARGET OF THE PROTOBERBERINE ALKALOID CORALYNE, Cancer research, 56(12), 1996, pp. 2795-2800
BIOPHYSICAL CHARACTERIZATION OF A CYTOTOXIC, TOPOISOMERASE I-POISONING TERBENZIMIDAZOLE AND ITS INTERACTIONS WITH A NATURAL DNA DUPLEX
Authors: PILCH DS XU ZT SUN Q LAVOIE EJ LIU LF GEACINTOV NE BRESLAUER KJ
Citation: Ds. Pilch et al., BIOPHYSICAL CHARACTERIZATION OF A CYTOTOXIC, TOPOISOMERASE I-POISONING TERBENZIMIDAZOLE AND ITS INTERACTIONS WITH A NATURAL DNA DUPLEX, Biophysical journal, 70(2), 1996, pp. 206-206
SOME OBSERVATIONS ON THE PALLADIUM-CATALYZED TRIFLATE-ARENE CYCLIZATION OF ELECTRON-RICH BIARYL SUBSTRATES
Authors: RICE JE CAI ZW HE ZM LAVOIE EJ
Citation: Je. Rice et al., SOME OBSERVATIONS ON THE PALLADIUM-CATALYZED TRIFLATE-ARENE CYCLIZATION OF ELECTRON-RICH BIARYL SUBSTRATES, Journal of organic chemistry, 60(24), 1995, pp. 8101-8104
SYNTHESIS AND EVALUATION OF TERBENZIMIDAZOLES AS TOPOISOMERASE-I INHIBITORS
Authors: SUN Q GATTO B YU C LIU A LIU LF LAVOIE EJ
Citation: Q. Sun et al., SYNTHESIS AND EVALUATION OF TERBENZIMIDAZOLES AS TOPOISOMERASE-I INHIBITORS, Journal of medicinal chemistry, 38(18), 1995, pp. 3638-3644
STRUCTURE-ACTIVITY OF TOPOISOMERASE-I POISONS RELATED TO HOECHST-33342
Authors: SUN Q GATTO B YU CA LIU A LIU LF LAVOIE EJ
Citation: Q. Sun et al., STRUCTURE-ACTIVITY OF TOPOISOMERASE-I POISONS RELATED TO HOECHST-33342, Bioorganic & medicinal chemistry letters, 4(24), 1994, pp. 2871-2876
TUMORIGENIC ACTIVITY OF FLUORANTHENE, 2-METHYLFLUORANTHENE AND 3-METHYLFLUORANTHENE IN NEWBORN CD-1 MICE
Authors: LAVOIE EJ CAI ZW MESCHTER CL WEYAND EH
Citation: Ej. Lavoie et al., TUMORIGENIC ACTIVITY OF FLUORANTHENE, 2-METHYLFLUORANTHENE AND 3-METHYLFLUORANTHENE IN NEWBORN CD-1 MICE, Carcinogenesis, 15(10), 1994, pp. 2131-2135
SYNTHESIS AND PHARMACOLOGICAL EVALUATION OF ISOINDOLO[1,2-B]QUINAZOLINONE AND ISOINDOLO[2,1-A]BENZIMIDAZOLE DERIVATIVES RELATED TO THE ANTITUMOR AGENT BATRACYLIN
Authors: MEEGALLA SK STEVENS GJ MCQUEEN CA CHEN AY YU C LIU LF BARROWS LR LAVOIE EJ
Citation: Sk. Meegalla et al., SYNTHESIS AND PHARMACOLOGICAL EVALUATION OF ISOINDOLO[1,2-B]QUINAZOLINONE AND ISOINDOLO[2,1-A]BENZIMIDAZOLE DERIVATIVES RELATED TO THE ANTITUMOR AGENT BATRACYLIN, Journal of medicinal chemistry, 37(20), 1994, pp. 3434-3439
TUMORIGENIC ACTIVITY OF THE 4,5-DIHYDRODIOLS AND 9,10-DIHYDRODIOLS OFBENZO[J]FLUORANTHENE AND THEIR SYN-DIOL AND ANTI-DIOL EPOXIDES IN NEWBORN MICE
Authors: LAVOIE EJ HE ZM WU Y MESCHTER CL WEYAND EH
Citation: Ej. Lavoie et al., TUMORIGENIC ACTIVITY OF THE 4,5-DIHYDRODIOLS AND 9,10-DIHYDRODIOLS OFBENZO[J]FLUORANTHENE AND THEIR SYN-DIOL AND ANTI-DIOL EPOXIDES IN NEWBORN MICE, Cancer research, 54(4), 1994, pp. 962-968
MUTAGENIC ACTIVITY OF THE 4,5-DIHYDRODIOLS AND 9,10-DIHYDRODIOLS OF BENZOI!FLUORANTHENE AND THEIR SYN-DIHYDRODIOL AND ANTI-DIHYDRODIOL EPOXIDES IN SALMONELLA-TYPHIMURIUM
Authors: MARSHALL MV HE ZM WEYAND EH RICE JE LAVOIE EJ
Citation: Mv. Marshall et al., MUTAGENIC ACTIVITY OF THE 4,5-DIHYDRODIOLS AND 9,10-DIHYDRODIOLS OF BENZOI!FLUORANTHENE AND THEIR SYN-DIHYDRODIOL AND ANTI-DIHYDRODIOL EPOXIDES IN SALMONELLA-TYPHIMURIUM, Environmental and molecular mutagenesis, 22(1), 1993, pp. 34-45
DETECTION OF THE MAJOR DNA-ADDUCTS OF BENZO[B]FLUORANTHENE IN MOUSE SKIN - ROLE OF PHENOLIC DIHYDRODIOLS
Authors: WEYAND EH CAI ZW WU Y RICE JE HE ZM LAVOIE EJ
Citation: Eh. Weyand et al., DETECTION OF THE MAJOR DNA-ADDUCTS OF BENZO[B]FLUORANTHENE IN MOUSE SKIN - ROLE OF PHENOLIC DIHYDRODIOLS, Chemical research in toxicology, 6(4), 1993, pp. 568-577
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