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CONFORMATIONALLY CONSTRAINED ANALOGS OF DIACYLGLYCEROL (DAG) - 14 - DISSECTION OF THE ROLES OF THE SN-1 AND SN-2 CARBONYLS IN DAG MIMETICS BY ISOPHARMACOPHORE REPLACEMENT
Authors: MARQUEZ VE SHARMA R WANG SM LEWIN NE BLUMBERG PM KIM IS LEE J
Citation: Ve. Marquez et al., CONFORMATIONALLY CONSTRAINED ANALOGS OF DIACYLGLYCEROL (DAG) - 14 - DISSECTION OF THE ROLES OF THE SN-1 AND SN-2 CARBONYLS IN DAG MIMETICS BY ISOPHARMACOPHORE REPLACEMENT, Bioorganic & medicinal chemistry letters, 8(13), 1998, pp. 1757-1762
CONFORMATIONALLY CONSTRAINED ANALOGS OF DIACYLGLYCEROL HAVING A PERHYDROFURO[3,4-C]FURAN-1,4-DIONE BIS-GAMMA-BUTYROLACTONE SKELETON
Authors: LEE J LEWIN NE BLUMBERG PM MARQUEZ VE
Citation: J. Lee et al., CONFORMATIONALLY CONSTRAINED ANALOGS OF DIACYLGLYCEROL HAVING A PERHYDROFURO[3,4-C]FURAN-1,4-DIONE BIS-GAMMA-BUTYROLACTONE SKELETON, Archives of pharmacal research, 21(2), 1998, pp. 164-167
SPECIFIC VANILLOID RESPONSES IN C6 RAT GLIOMA-CELLS
Authors: BIRO T BRODIE C MODARRES S LEWIN NE ACS P BLUMBERG PM
Citation: T. Biro et al., SPECIFIC VANILLOID RESPONSES IN C6 RAT GLIOMA-CELLS, Molecular brain research, 56(1-2), 1998, pp. 89-98
CHARACTERIZATION OF FUNCTIONAL VANILLOID RECEPTORS EXPRESSED BY MAST-CELLS
Authors: BIRO T MAURER M MODARRES S LEWIN NE BRODIE C ACS G ACS P PAUS R BLUMBERG PM
Citation: T. Biro et al., CHARACTERIZATION OF FUNCTIONAL VANILLOID RECEPTORS EXPRESSED BY MAST-CELLS, Blood, 91(4), 1998, pp. 1332-1340
STRUCTURE-BASED DESIGN OF A NEW CLASS OF PROTEIN-KINASE-C MODULATORS
Authors: QIAO LX WANG SM GEORGE C LEWIN NE BLUMBERG PM KOZIKOWSKI AP
Citation: Lx. Qiao et al., STRUCTURE-BASED DESIGN OF A NEW CLASS OF PROTEIN-KINASE-C MODULATORS, Journal of the American Chemical Society, 120(26), 1998, pp. 6629-6630
MODELING CHEMISTRY, AND BIOLOGY OF THE BENZOLACTAM ANALOGS OF INDOLACTAM-V (ILV) .2. IDENTIFICATION OF THE BINDING-SITE OF THE BENZOLACTAMSIN THE CRD2 ACTIVATOR-BINDING DOMAIN OF PKC-DELTA AND DISCOVERY OF ANILV ANALOG OF IMPROVED ISOZYME SELECTIVITY
Authors: KOZIKOWSKI AP WANG SM MA DW YAO JC AHMAD S GLAZER RI BOGI K ACS P MODARRES S LEWIN NE BLUMBERG PM
Citation: Ap. Kozikowski et al., MODELING CHEMISTRY, AND BIOLOGY OF THE BENZOLACTAM ANALOGS OF INDOLACTAM-V (ILV) .2. IDENTIFICATION OF THE BINDING-SITE OF THE BENZOLACTAMSIN THE CRD2 ACTIVATOR-BINDING DOMAIN OF PKC-DELTA AND DISCOVERY OF ANILV ANALOG OF IMPROVED ISOZYME SELECTIVITY, Journal of medicinal chemistry, 40(9), 1997, pp. 1316-1326
CONFORMATIONALLY CONSTRAINED ANALOGS OF DIACYLGLYCEROL .13. PROTEIN-KINASE-C LIGANDS BASED ON TEMPLATES DERIVED FROM 2,3-DIDEOXY-L-ERYTHRO(THREO)-HEXONO-1,4-LACTONE AND 2-DEOXYAPIOLACTONE (VOL 39, PG 4915, 1996)
Authors: LEE J LEWIN NE ACS P BLUMBERG PM MARQUEZ VE
Citation: J. Lee et al., CONFORMATIONALLY CONSTRAINED ANALOGS OF DIACYLGLYCEROL .13. PROTEIN-KINASE-C LIGANDS BASED ON TEMPLATES DERIVED FROM 2,3-DIDEOXY-L-ERYTHRO(THREO)-HEXONO-1,4-LACTONE AND 2-DEOXYAPIOLACTONE (VOL 39, PG 4915, 1996), Journal of medicinal chemistry, 40(10), 1997, pp. 1560-1560
BETA-2-CHIMAERIN IS A HIGH-AFFINITY RECEPTOR FOR THE PHORBOL ESTER TUMOR PROMOTERS
Authors: CALOCA MJ FERNANDEZ N LEWIN NE CHING DX MODALI R BLUMBERG PM KAZANIETZ MG
Citation: Mj. Caloca et al., BETA-2-CHIMAERIN IS A HIGH-AFFINITY RECEPTOR FOR THE PHORBOL ESTER TUMOR PROMOTERS, The Journal of biological chemistry, 272(42), 1997, pp. 26488-26496
ANTINEOPLASTIC AGENTS .340. ISOLATION AND STRUCTURAL ELUCIDATION OF BRYOSTATINS-16-18
Authors: PETTIT GR GAO F BLUMBERG PM HERALD CL COLL JC KAMANO Y LEWIN NE SCHMIDT JM CHAPUIS JC
Citation: Gr. Pettit et al., ANTINEOPLASTIC AGENTS .340. ISOLATION AND STRUCTURAL ELUCIDATION OF BRYOSTATINS-16-18, Journal of natural products, 59(3), 1996, pp. 286-289
CONFORMATIONALLY CONSTRAINED ANALOGS OF DIACYLGLYCEROL .13. PROTEIN-KINASE-C LIGANDS BASED ON TEMPLATES DERIVED FROM 2,3-DIDEOXY-L-ERYTHRO(THREO)-HEXONO-1,4-LACTONE AND 2-DEOXYAPIOLACTONE
Authors: LEE J LEWIN NE ACS P BLUMBERG PM MARQUEZ VE
Citation: J. Lee et al., CONFORMATIONALLY CONSTRAINED ANALOGS OF DIACYLGLYCEROL .13. PROTEIN-KINASE-C LIGANDS BASED ON TEMPLATES DERIVED FROM 2,3-DIDEOXY-L-ERYTHRO(THREO)-HEXONO-1,4-LACTONE AND 2-DEOXYAPIOLACTONE, Journal of medicinal chemistry, 39(25), 1996, pp. 4912-4919
CONFORMATIONALLY CONSTRAINED ANALOGS OF DIACYLGLYCEROL .10. ULTRAPOTENT PROTEIN-KINASE-C LIGANDS BASED ON A RACEMIC 5-DISUBSTITUTED TETRAHYDRO-2-FURANONE TEMPLATE
Authors: SHARMA R LEE J WANG SM MILNE GWA LEWIN NE BLUMBERG PM MARQUEZ VE
Citation: R. Sharma et al., CONFORMATIONALLY CONSTRAINED ANALOGS OF DIACYLGLYCEROL .10. ULTRAPOTENT PROTEIN-KINASE-C LIGANDS BASED ON A RACEMIC 5-DISUBSTITUTED TETRAHYDRO-2-FURANONE TEMPLATE, Journal of medicinal chemistry, 39(1), 1996, pp. 19-28
CONFORMATIONALLY CONSTRAINED ANALOGS OF DIACYLGLYCEROL .11. ULTRAPOTENT PROTEIN-KINASE-C LIGANDS BASED ON A CHIRAL 5-DISUBSTITUTED TETRAHYDRO-2-FURANONE TEMPLATE
Authors: LEE J WANG SM MILNE GWA SHARMA R LEWIN NE BLUMBERG PM MARQUEZ VE
Citation: J. Lee et al., CONFORMATIONALLY CONSTRAINED ANALOGS OF DIACYLGLYCEROL .11. ULTRAPOTENT PROTEIN-KINASE-C LIGANDS BASED ON A CHIRAL 5-DISUBSTITUTED TETRAHYDRO-2-FURANONE TEMPLATE, Journal of medicinal chemistry, 39(1), 1996, pp. 29-35
CONFORMATIONALLY CONSTRAINED ANALOGS OF DIACYLGLYCEROL .12. ULTRAPOTENT PROTEIN-KINASE-C LIGANDS BASED ON A CHIRAL 4,4-DISUBSTITUTED HEPTONO-1,4-LACTONE TEMPLATE
Authors: LEE J SHARMA R WANG SM MILNE GWA LEWIN NE SZALLASI Z BLUMBERG PM GEORGE C MARQUEZ VE
Citation: J. Lee et al., CONFORMATIONALLY CONSTRAINED ANALOGS OF DIACYLGLYCEROL .12. ULTRAPOTENT PROTEIN-KINASE-C LIGANDS BASED ON A CHIRAL 4,4-DISUBSTITUTED HEPTONO-1,4-LACTONE TEMPLATE, Journal of medicinal chemistry, 39(1), 1996, pp. 36-45
THE BRYOSTATINS INHIBIT GROWTH OF B16 F10 MELANOMA-CELLS IN-VITRO THROUGH A PROTEIN-KINASE C-INDEPENDENT MECHANISM - DISSOCIATION OF ACTIVITIES USING 26-EPI-BRYOSTATIN-1/
Authors: SZALLASI Z DU L LEVINE R LEWIN NE NGUYEN PN WILLIAMS MD PETTIT GR BLUMBERG PM
Citation: Z. Szallasi et al., THE BRYOSTATINS INHIBIT GROWTH OF B16 F10 MELANOMA-CELLS IN-VITRO THROUGH A PROTEIN-KINASE C-INDEPENDENT MECHANISM - DISSOCIATION OF ACTIVITIES USING 26-EPI-BRYOSTATIN-1/, Cancer research, 56(9), 1996, pp. 2105-2111
ON THE PROTEIN-KINASE-C PHARMACOPHORE - SYNTHESIS AND BIOLOGICAL-ACTIVITY OF 4-HYDROXYLATED ANALOGS OF INGENOL
Authors: WINKLER JD HONG BC KIM S LEWIN NE BLUMBERG PM
Citation: Jd. Winkler et al., ON THE PROTEIN-KINASE-C PHARMACOPHORE - SYNTHESIS AND BIOLOGICAL-ACTIVITY OF 4-HYDROXYLATED ANALOGS OF INGENOL, Synlett, (5), 1995, pp. 533-535
RESINIFERATOXIN-AMIDE AND ANALOGS AS LIGANDS FOR PROTEIN-KINASE-C ANDVANILLOID RECEPTORS AND DETERMINATION OF THEIR BIOLOGICAL-ACTIVITIES AS VANILLOIDS
Authors: ACS G LEE J MARQUEZ VE WANG SM MILNE GWA DU L LEWIN NE BLUMBERG PM
Citation: G. Acs et al., RESINIFERATOXIN-AMIDE AND ANALOGS AS LIGANDS FOR PROTEIN-KINASE-C ANDVANILLOID RECEPTORS AND DETERMINATION OF THEIR BIOLOGICAL-ACTIVITIES AS VANILLOIDS, Journal of neurochemistry, 65(1), 1995, pp. 301-308
RESIDUES IN THE 2ND CYSTEINE-RICH REGION OF PROTEIN-KINASE-C-DELTA RELEVANT TO PHORBOL ESTER BINDING AS REVEALED BY SITE-DIRECTED MUTAGENESIS
Authors: KAZANIETZ MG WANG S MILNE GWA LEWIN NE LIU HL BLUMBERG PM
Citation: Mg. Kazanietz et al., RESIDUES IN THE 2ND CYSTEINE-RICH REGION OF PROTEIN-KINASE-C-DELTA RELEVANT TO PHORBOL ESTER BINDING AS REVEALED BY SITE-DIRECTED MUTAGENESIS, The Journal of biological chemistry, 270(37), 1995, pp. 21852-21859
CHARACTERIZATION OF THE CYSTEINE-RICH REGION OF THE CAENORHABDITIS-ELEGANS PROTEIN UNC-13 AS A HIGH-AFFINITY PHORBOL ESTER RECEPTOR - ANALYSIS OF LIGAND-BINDING INTERACTIONS, LIPID COFACTOR REQUIREMENTS, AND INHIBITOR SENSITIVITY
Authors: KAZANIETZ MG LEWIN NE BRUNS JD BLUMBERG PM
Citation: Mg. Kazanietz et al., CHARACTERIZATION OF THE CYSTEINE-RICH REGION OF THE CAENORHABDITIS-ELEGANS PROTEIN UNC-13 AS A HIGH-AFFINITY PHORBOL ESTER RECEPTOR - ANALYSIS OF LIGAND-BINDING INTERACTIONS, LIPID COFACTOR REQUIREMENTS, AND INHIBITOR SENSITIVITY, The Journal of biological chemistry, 270(18), 1995, pp. 10777-10783
EFFECT OF ALTERATION OF THE HETEROCYCLIC NUCLEUS OF ILV ON ITS ISOFORM SELECTIVITY FOR PKC - PALLADIUM-CATALYZED ROUTE TO BENZOFURAN ANALOGS OF ILV
Authors: KOZIKOWSKI AP MA DW DU L LEWIN NE BLUMBERG PM
Citation: Ap. Kozikowski et al., EFFECT OF ALTERATION OF THE HETEROCYCLIC NUCLEUS OF ILV ON ITS ISOFORM SELECTIVITY FOR PKC - PALLADIUM-CATALYZED ROUTE TO BENZOFURAN ANALOGS OF ILV, Il Farmaco, 50(6), 1995, pp. 425-430
EFFECT OF ALTERATION OF THE HETEROCYCLIC NUCLEUS OF ILV ON ITS ISOFORM SELECTIVITY FOR PKC - PALLADIUM-CATALYZED ROUTE TO BENZOFURAN ANALOGS OF ILV
Authors: KOZIKOWSKI AP MA DW DU L LEWIN NE BLUMBERG PM
Citation: Ap. Kozikowski et al., EFFECT OF ALTERATION OF THE HETEROCYCLIC NUCLEUS OF ILV ON ITS ISOFORM SELECTIVITY FOR PKC - PALLADIUM-CATALYZED ROUTE TO BENZOFURAN ANALOGS OF ILV, Journal of the American Chemical Society, 117(25), 1995, pp. 6666-6672
CONFORMATIONALLY CONSTRAINED ANALOGS OF DAG .7. INTERACTION OF A MEDIUM-SIZE EPSILON-LACTONE WITH PROTEIN-KINASE-C (PK-C)
Authors: LEE JW MARQUEZ VE LEWIN NE BLUMBERG PM
Citation: Jw. Lee et al., CONFORMATIONALLY CONSTRAINED ANALOGS OF DAG .7. INTERACTION OF A MEDIUM-SIZE EPSILON-LACTONE WITH PROTEIN-KINASE-C (PK-C), Bioorganic & medicinal chemistry letters, 4(4), 1994, pp. 543-548
SYNTHESIS OF THE BENZOFURAN ANALOG OF ILV, A NEW-PROTEIN KINASE-C (PKC) ACTIVATOR
Authors: KOZIKOWSKI AP MA DW DU L LEWIN NE BLUMBERG PM
Citation: Ap. Kozikowski et al., SYNTHESIS OF THE BENZOFURAN ANALOG OF ILV, A NEW-PROTEIN KINASE-C (PKC) ACTIVATOR, Bioorganic & medicinal chemistry letters, 4(4), 1994, pp. 637-640
CONFORMATIONALLY CONSTRAINED ANALOGS OF DIACYLGLYCEROL .9. THE EFFECTOF SIDE-CHAIN ORIENTATION ON THE PROTEIN-KINASE-C (PK-C) BINDING-AFFINITY OF DELTA-LACTONES
Authors: LEE JW LEWIN NE BLUMBERG PM MARQUEZ VE
Citation: Jw. Lee et al., CONFORMATIONALLY CONSTRAINED ANALOGS OF DIACYLGLYCEROL .9. THE EFFECTOF SIDE-CHAIN ORIENTATION ON THE PROTEIN-KINASE-C (PK-C) BINDING-AFFINITY OF DELTA-LACTONES, Bioorganic & medicinal chemistry letters, 4(20), 1994, pp. 2405-2410
CONFORMATIONALLY CONSTRAINED ANALOGS OF DIACYLGLYCEROL .6. CHANGES INPK-C BINDING-AFFINITY FOR 3-O-ACYL-2-DEOXY-L-RIBONOLACTONES BEARING DIFFERENT ACYL CHAINS
Authors: MARQUEZ VE LEE JW SHARMA R TENG K WANG SM LEWIN NE BAHADOR A KAZANIETZ MG BLUMBERG PM
Citation: Ve. Marquez et al., CONFORMATIONALLY CONSTRAINED ANALOGS OF DIACYLGLYCEROL .6. CHANGES INPK-C BINDING-AFFINITY FOR 3-O-ACYL-2-DEOXY-L-RIBONOLACTONES BEARING DIFFERENT ACYL CHAINS, Bioorganic & medicinal chemistry letters, 4(2), 1994, pp. 355-360
CONFORMATIONALLY CONSTRAINED ANALOGS OF DAG .8. CHANGES IN PK-C BINDING-AFFINITY PRODUCED BY ISOSTERIC GROUPS OF THE 3-O-ACYL FUNCTION IN 2-DEOXY-L-RIBONOLACTONES
Authors: LEE JW SHARMA R TENG K LEWIN NE BLUMBERG PM MARQUEZ VE
Citation: Jw. Lee et al., CONFORMATIONALLY CONSTRAINED ANALOGS OF DAG .8. CHANGES IN PK-C BINDING-AFFINITY PRODUCED BY ISOSTERIC GROUPS OF THE 3-O-ACYL FUNCTION IN 2-DEOXY-L-RIBONOLACTONES, Bioorganic & medicinal chemistry letters, 4(11), 1994, pp. 1369-1374
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