AAAAAA

   
Results: 1-25 | 26-50 | 51-54
Results: 1-25/54
EVOLUTION OF THE CYTOCHROME-P450 SUPERFAMILY - SEQUENCE ALIGNMENTS AND PHARMACOGENETICS
Authors: LEWIS DFV WATSON E LAKE BG
Citation: Dfv. Lewis et al., EVOLUTION OF THE CYTOCHROME-P450 SUPERFAMILY - SEQUENCE ALIGNMENTS AND PHARMACOGENETICS, Mutation research-reviews in mutation research, 410(3), 1998, pp. 245-270
FURTHER EVALUATION OF COMPACT, THE MOLECULAR-ORBITAL APPROACH FOR THEPROSPECTIVE SAFETY EVALUATION OF CHEMICALS
Authors: LEWIS DFV IOANNIDES C PARKE DV
Citation: Dfv. Lewis et al., FURTHER EVALUATION OF COMPACT, THE MOLECULAR-ORBITAL APPROACH FOR THEPROSPECTIVE SAFETY EVALUATION OF CHEMICALS, Mutation research. Genetic toxicology and environmental mutagenesis, 412(1), 1998, pp. 41-54
AMINO-ACID RESIDUE-250 HAS A FUNCTIONAL-ROLE IN THE ASSEMBLY OF RABBIT LIVER MICROSOMAL CYTOCHROME-P450-2B4
Authors: SCHULZE J LEHNERER M LEWIS DFV HLAVICA P
Citation: J. Schulze et al., AMINO-ACID RESIDUE-250 HAS A FUNCTIONAL-ROLE IN THE ASSEMBLY OF RABBIT LIVER MICROSOMAL CYTOCHROME-P450-2B4, Biochemistry and molecular biology international, 44(6), 1998, pp. 1147-1155
A COMBINED COMPACT AND HAZARDEXPERT STUDY OF 40 CHEMICALS FOR WHICH INFORMATION ON MUTAGENICITY AND CARCINOGENICITY IS KNOWN, INCLUDING THERESULTS OF HUMAN EPIDEMIOLOGIC STUDIES
Authors: LEWIS DFV IOANNIDES C PARKE DV
Citation: Dfv. Lewis et al., A COMBINED COMPACT AND HAZARDEXPERT STUDY OF 40 CHEMICALS FOR WHICH INFORMATION ON MUTAGENICITY AND CARCINOGENICITY IS KNOWN, INCLUDING THERESULTS OF HUMAN EPIDEMIOLOGIC STUDIES, Human & experimental toxicology, 17(10), 1998, pp. 577-586
MOLECULAR MODELING OF STEROIDOGENIC CYTOCHROMES P450 FROM FAMILIES CYP11, CYP17, CYP19 AND CYP21 BASED ON THE CYP102 CRYSTAL-STRUCTURE
Authors: LEWIS DFV LEEROBICHAUD P
Citation: Dfv. Lewis et P. Leerobichaud, MOLECULAR MODELING OF STEROIDOGENIC CYTOCHROMES P450 FROM FAMILIES CYP11, CYP17, CYP19 AND CYP21 BASED ON THE CYP102 CRYSTAL-STRUCTURE, Journal of steroid biochemistry and molecular biology, 66(4), 1998, pp. 217-233
MOLECULAR MODELING AND QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP STUDIES ON THE INTERACTION OF OMEPRAZOLE WITH CYTOCHROME-P450 ISOZYMES
Authors: LEWIS DFV LAKE BG
Citation: Dfv. Lewis et Bg. Lake, MOLECULAR MODELING AND QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP STUDIES ON THE INTERACTION OF OMEPRAZOLE WITH CYTOCHROME-P450 ISOZYMES, Toxicology, 125(1), 1998, pp. 31-44
ENVIRONMENTAL ESTROGEN-MIMICS DISPLAY LIPOSOMAL MEMBRANE-ANTIOXIDANT ABILITY - IMPORTANCE OF MOLECULAR MODELING PREDICTIONS
Authors: LEADLEY J LEWIS DFV WISEMAN H GOLDFARB PS WISEMAN A
Citation: J. Leadley et al., ENVIRONMENTAL ESTROGEN-MIMICS DISPLAY LIPOSOMAL MEMBRANE-ANTIOXIDANT ABILITY - IMPORTANCE OF MOLECULAR MODELING PREDICTIONS, Journal of chemical technology and biotechnology, 73(2), 1998, pp. 131-136
CYTOCHROMES P450 AND SPECIES-DIFFERENCES IN XENOBIOTIC METABOLISM ANDACTIVATION OF CARCINOGEN
Authors: LEWIS DFV IOANNIDES C PARKE DV
Citation: Dfv. Lewis et al., CYTOCHROMES P450 AND SPECIES-DIFFERENCES IN XENOBIOTIC METABOLISM ANDACTIVATION OF CARCINOGEN, Environmental health perspectives, 106(10), 1998, pp. 633-641
THE CYP2 FAMILY - MODELS, MUTANTS AND INTERACTIONS
Authors: LEWIS DFV
Citation: Dfv. Lewis, THE CYP2 FAMILY - MODELS, MUTANTS AND INTERACTIONS, Xenobiotica, 28(7), 1998, pp. 617-661
MOLECULAR MODELING OF HUMAN CYP2C SUBFAMILY ENZYMES CYP2C9 AND CYP2C19 - RATIONALIZATION OF SUBSTRATE-SPECIFICITY AND SITE-DIRECTED MUTAGENESIS EXPERIMENTS IN THE CYP2C SUBFAMILY
Authors: LEWIS DFV DICKINS M WEAVER RJ EDDERSHAW PJ GOLDFARB PS TARBIT MH
Citation: Dfv. Lewis et al., MOLECULAR MODELING OF HUMAN CYP2C SUBFAMILY ENZYMES CYP2C9 AND CYP2C19 - RATIONALIZATION OF SUBSTRATE-SPECIFICITY AND SITE-DIRECTED MUTAGENESIS EXPERIMENTS IN THE CYP2C SUBFAMILY, Xenobiotica, 28(3), 1998, pp. 235-268
INFLUENCE OF MUTATION OF THE AMINO-TERMINAL SIGNAL ANCHOR SEQUENCE OFCYTOCHROME-P450 2B4 ON THE ENZYME STRUCTURE AND ELECTRON-TRANSFER PROCESSES
Authors: LEHNERER M SCHULZE J PERNECKY SJ LEWIS DFV EULITZ M HLAVICA P
Citation: M. Lehnerer et al., INFLUENCE OF MUTATION OF THE AMINO-TERMINAL SIGNAL ANCHOR SEQUENCE OFCYTOCHROME-P450 2B4 ON THE ENZYME STRUCTURE AND ELECTRON-TRANSFER PROCESSES, Journal of Biochemistry, 124(2), 1998, pp. 396-403
STRUCTURAL DETERMINANTS OF CYTOCHROME-P450 SUBSTRATE-SPECIFICITY, BINDING-AFFINITY AND CATALYTIC RATE
Authors: LEWIS DFV EDDERSHAW PJ DICKENS M TARBIT MH GOLDFARB PS
Citation: Dfv. Lewis et al., STRUCTURAL DETERMINANTS OF CYTOCHROME-P450 SUBSTRATE-SPECIFICITY, BINDING-AFFINITY AND CATALYTIC RATE, Chemico-biological interactions, 115(3), 1998, pp. 175-199
QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP (QSAR) ANALYSIS FOR A SERIES OF RODENT PEROXISOME PROLIFERATORS - INTERACTION WITH THE MOUSE-LIVER PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR-ALPHA (MPPAR-ALPHA)
Authors: LEWIS DFV LAKE BG
Citation: Dfv. Lewis et Bg. Lake, QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP (QSAR) ANALYSIS FOR A SERIES OF RODENT PEROXISOME PROLIFERATORS - INTERACTION WITH THE MOUSE-LIVER PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR-ALPHA (MPPAR-ALPHA), Toxicology in vitro, 11(1-2), 1997, pp. 99-105
NITROSAMINE CARCINOGENESIS - RODENT ASSAYS, QUANTITATIVE STRUCTURE-ACTIVITY-RELATIONSHIPS, AND HUMAN RISK ASSESSMENT
Authors: LEWIS DFV BRANTOM PG IOANNIDES C WALKER R PARKE DV
Citation: Dfv. Lewis et al., NITROSAMINE CARCINOGENESIS - RODENT ASSAYS, QUANTITATIVE STRUCTURE-ACTIVITY-RELATIONSHIPS, AND HUMAN RISK ASSESSMENT, Drug metabolism reviews, 29(4), 1997, pp. 1055-1078
QUANTITATIVE STRUCTURE-ACTIVITY-RELATIONSHIPS IN SUBSTRATES, INDUCERS, AND INHIBITORS OF CYTOCHROME P4501 (CYP1)
Authors: LEWIS DFV
Citation: Dfv. Lewis, QUANTITATIVE STRUCTURE-ACTIVITY-RELATIONSHIPS IN SUBSTRATES, INDUCERS, AND INHIBITORS OF CYTOCHROME P4501 (CYP1), Drug metabolism reviews, 29(3), 1997, pp. 589-650
MOLECULAR MODELING OF CYP2E1 ENZYMES FROM RAT, MOUSE AND MAN - AN EXPLANATION FOR SPECIES-DIFFERENCES IN BUTADIENE METABOLISM AND POTENTIALCARCINOGENICITY, AND RATIONALIZATION OF CYP2E SUBSTRATE-SPECIFICITY
Authors: LEWIS DFV BIRD MG PARKE DV
Citation: Dfv. Lewis et al., MOLECULAR MODELING OF CYP2E1 ENZYMES FROM RAT, MOUSE AND MAN - AN EXPLANATION FOR SPECIES-DIFFERENCES IN BUTADIENE METABOLISM AND POTENTIALCARCINOGENICITY, AND RATIONALIZATION OF CYP2E SUBSTRATE-SPECIFICITY, Toxicology, 118(2-3), 1997, pp. 93-113
DIAMINONAPHTHALENES AND RELATED AMINOCOMPOUNDS - MUTAGENICITY, CYP1A INDUCTION AND INTERACTION WITH THE AH RECEPTOR
Authors: CHEUNG YL LEWIS DFV RIDD TI GRAY TJB IOANNIDES C
Citation: Yl. Cheung et al., DIAMINONAPHTHALENES AND RELATED AMINOCOMPOUNDS - MUTAGENICITY, CYP1A INDUCTION AND INTERACTION WITH THE AH RECEPTOR, Toxicology, 118(2-3), 1997, pp. 115-127
MOLECULAR MODELING OF MAMMALIAN CYP2B ISOFORMS AND THEIR INTERACTION WITH SUBSTRATES, INHIBITORS AND REDOX PARTNERS
Authors: LEWIS DFV LAKE BG
Citation: Dfv. Lewis et Bg. Lake, MOLECULAR MODELING OF MAMMALIAN CYP2B ISOFORMS AND THEIR INTERACTION WITH SUBSTRATES, INHIBITORS AND REDOX PARTNERS, Xenobiotica, 27(5), 1997, pp. 443-478
MOLECULAR MODELING OF CYTOCHROME P4502D6 (CYP2D6) BASED ON AN ALIGNMENT WITH CYP102 - STRUCTURAL STUDIES ON SPECIFIC CYP2D6 SUBSTRATE METABOLISM
Authors: LEWIS DFV EDDERSHAW PJ GOLDFARB PS TARBIT MH
Citation: Dfv. Lewis et al., MOLECULAR MODELING OF CYTOCHROME P4502D6 (CYP2D6) BASED ON AN ALIGNMENT WITH CYP102 - STRUCTURAL STUDIES ON SPECIFIC CYP2D6 SUBSTRATE METABOLISM, Xenobiotica, 27(4), 1997, pp. 319-339
CYTOCHROME P4501A (CYP1A) INDUCTION IN RAT AND MAN BY THE BENZODIOXINO DERIVATIVE, FLUPAROXAN
Authors: BERESFORD AP ELLIS WJ AYRTON J JOHNSON MA LEWIS DFV
Citation: Ap. Beresford et al., CYTOCHROME P4501A (CYP1A) INDUCTION IN RAT AND MAN BY THE BENZODIOXINO DERIVATIVE, FLUPAROXAN, Xenobiotica, 27(2), 1997, pp. 159-173
IN-VITRO METABOLISM OF DEXAMETHASONE (DEX) IN HUMAN LIVER AND KIDNEY - THE INVOLVEMENT OF CYP3A4 AND CYP17 (17,20 LYASE) AND MOLECULAR MODELING STUDIES
Authors: TOMLINSON ES LEWIS DFV MAGGS JL KROEMER HK PARK BK BACK DJ
Citation: Es. Tomlinson et al., IN-VITRO METABOLISM OF DEXAMETHASONE (DEX) IN HUMAN LIVER AND KIDNEY - THE INVOLVEMENT OF CYP3A4 AND CYP17 (17,20 LYASE) AND MOLECULAR MODELING STUDIES, Biochemical pharmacology, 54(5), 1997, pp. 605-611
A VALIDATION-STUDY OF THE COMPACT AND HAZARDEXPERT TECHNIQUES WITH 40CHEMICALS
Authors: LEWIS DFV LANGLEY GR
Citation: Dfv. Lewis et Gr. Langley, A VALIDATION-STUDY OF THE COMPACT AND HAZARDEXPERT TECHNIQUES WITH 40CHEMICALS, Mutation research. Genetic toxicology testing, 369(3-4), 1996, pp. 157-174
THE METABOLISM OF TAMOXIFEN BY HUMAN CYTOCHROMES P450 IS RATIONALIZEDBY MOLECULAR MODELING OF THE ENZYME-SUBSTRATE INTERACTIONS - POTENTIAL IMPORTANCE TO ITS PROPOSED ANTI-CARCINOGENIC CARCINOGENIC ACTIONS/
Authors: WISEMAN H LEWIS DFV
Citation: H. Wiseman et Dfv. Lewis, THE METABOLISM OF TAMOXIFEN BY HUMAN CYTOCHROMES P450 IS RATIONALIZEDBY MOLECULAR MODELING OF THE ENZYME-SUBSTRATE INTERACTIONS - POTENTIAL IMPORTANCE TO ITS PROPOSED ANTI-CARCINOGENIC CARCINOGENIC ACTIONS/, Carcinogenesis, 17(6), 1996, pp. 1357-1360
COMPACT AND MOLECULAR-STRUCTURE IN TOXICITY ASSESSMENT - A PROSPECTIVE EVALUATION OF 30 CHEMICALS CURRENTLY BEING TESTED FOR RODENT CARCINOGENICITY BY THE NCI NTP/
Authors: LEWIS DFV IOANNIDES C PARKE DV
Citation: Dfv. Lewis et al., COMPACT AND MOLECULAR-STRUCTURE IN TOXICITY ASSESSMENT - A PROSPECTIVE EVALUATION OF 30 CHEMICALS CURRENTLY BEING TESTED FOR RODENT CARCINOGENICITY BY THE NCI NTP/, Environmental health perspectives, 104, 1996, pp. 1011-1016
MOLECULAR MODELING OF CYP1A SUBFAMILY MEMBERS BASED ON AN ALIGNMENT WITH CYP102 - RATIONALIZATION OF CYP1A SUBSTRATE-SPECIFICITY IN TERMS OF ACTIVE-SITE AMINO-ACID-RESIDUES
Authors: LEWIS DFV LAKE BG
Citation: Dfv. Lewis et Bg. Lake, MOLECULAR MODELING OF CYP1A SUBFAMILY MEMBERS BASED ON AN ALIGNMENT WITH CYP102 - RATIONALIZATION OF CYP1A SUBSTRATE-SPECIFICITY IN TERMS OF ACTIVE-SITE AMINO-ACID-RESIDUES, Xenobiotica, 26(7), 1996, pp. 723-753
Risultati: 1-25 | 26-50 | 51-54