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Results: 1-15 |
Results: 15
Synthesis of 7,8-disubstituted benzolactam-V8 and its binding to protein kinase C
Authors: Ma, DW Zhang, T Wang, GQ Kozikowski, AP Lewin, NE Blumberg, PM
Citation: Dw. Ma et al., Synthesis of 7,8-disubstituted benzolactam-V8 and its binding to protein kinase C, BIOORG MED, 11(2), 2001, pp. 99-101
Conformationally constrained analogues of diacylglycerol. 18. The incorporation of a hydroxamate moiety into diacylglycerol-lactones reduces lipophilicity and helps discriminate between sn-1 and sn-2 binding modes to proteinkinase c (PK-C). Implications for isozyme specificity
Authors: Lee, J Han, KC Kang, JH Pearce, LL Lewin, NE Yan, SQ Benzaria, S Nicklaus, MC Blumberg, PM Marquez, VE
Citation: J. Lee et al., Conformationally constrained analogues of diacylglycerol. 18. The incorporation of a hydroxamate moiety into diacylglycerol-lactones reduces lipophilicity and helps discriminate between sn-1 and sn-2 binding modes to proteinkinase c (PK-C). Implications for isozyme specificity, J MED CHEM, 44(25), 2001, pp. 4309-4312
Iridals are a novel class of ligands for phorbol ester receptors with modest selectivity for the RasGRP receptor subfamily
Authors: Shao, L Lewin, NE Lorenzo, PS Hu, ZJ Enyedy, IJ Garfield, SH Stone, JC Marner, FJ Blumberg, PM Wang, SM
Citation: L. Shao et al., Iridals are a novel class of ligands for phorbol ester receptors with modest selectivity for the RasGRP receptor subfamily, J MED CHEM, 44(23), 2001, pp. 3872-3880
An optimized protein kinase C activating diacylglycerol combining high binding affinity (K-i) with reduced lipophilicity (log P)
Authors: Nacro, K Sigano, DM Yan, SQ Nicklaus, MC Pearce, LL Lewin, NE Garfield, SH Blumberg, PM Marquez, VE
Citation: K. Nacro et al., An optimized protein kinase C activating diacylglycerol combining high binding affinity (K-i) with reduced lipophilicity (log P), J MED CHEM, 44(12), 2001, pp. 1892-1904
Diacylglycerols with lipophilically equivalent branched acyl chains display high affinity for protein kinase C (PK-C). A direct measure of the effectof constraining the glycerol backbone in DAG lactones
Authors: Nacro, K Bienfait, B Lewin, NE Blumberg, PM Marquez, VE
Citation: K. Nacro et al., Diacylglycerols with lipophilically equivalent branched acyl chains display high affinity for protein kinase C (PK-C). A direct measure of the effectof constraining the glycerol backbone in DAG lactones, BIOORG MED, 10(7), 2000, pp. 653-655
Diacylglycerols with lipophilically equivalent branched acyl chains display high affinity for protein kinase C (PK-C). A direct measure of the effectof constraining the glycerol backbone in DAG lactones (vol 10, pg 653, 2000)
Authors: Nacro, K Bienfait, B Lewin, NE Blumberg, PM Marquez, VE
Citation: K. Nacro et al., Diacylglycerols with lipophilically equivalent branched acyl chains display high affinity for protein kinase C (PK-C). A direct measure of the effectof constraining the glycerol backbone in DAG lactones (vol 10, pg 653, 2000), BIOORG MED, 10(12), 2000, pp. 1401-1401
Conformationally constrained analogues of diacylglycerol (DAG). 16. How much structural complexity is necessary for recognition and high binding affinity to protein kinase C?
Authors: Nacro, K Bienfait, B Lee, J Han, KC Kang, JH Benzaria, S Lewin, NE Bhattacharyya, DK Blumberg, PM Marquez, VE
Citation: K. Nacro et al., Conformationally constrained analogues of diacylglycerol (DAG). 16. How much structural complexity is necessary for recognition and high binding affinity to protein kinase C?, J MED CHEM, 43(5), 2000, pp. 921-944
Conformationally constrained analogues of diacylglycerol (DAG). 17. Contrast between sn-1 and sn-2 DAG lactones in binding to protein kinase C
Authors: Tamamura, H Bienfait, B Nacro, K Lewin, NE Blumberg, PM Marquez, VE
Citation: H. Tamamura et al., Conformationally constrained analogues of diacylglycerol (DAG). 17. Contrast between sn-1 and sn-2 DAG lactones in binding to protein kinase C, J MED CHEM, 43(17), 2000, pp. 3209-3217
Synthesis and protein kinase C binding activity of benzolactam-V7
Authors: Ma, DW Wang, GQ Wang, SM Kozikowski, AP Lewin, NE Blumberg, PM
Citation: Dw. Ma et al., Synthesis and protein kinase C binding activity of benzolactam-V7, BIOORG MED, 9(10), 1999, pp. 1371-1374
The transition from a pharmacophore-guided approach to a receptor-guided approach in the design of potent protein kinase C ligands
Authors: Marquez, VE Nacro, K Benzaria, S Lee, J Sharma, R Teng, K Milne, GWA Bienfait, B Wang, SM Lewin, NE Blumberg, PM
Citation: Ve. Marquez et al., The transition from a pharmacophore-guided approach to a receptor-guided approach in the design of potent protein kinase C ligands, PHARM THERA, 82(2-3), 1999, pp. 251-261
beta 2-chimaerin is a novel target for diacylglycerol: Binding properties and changes in subcellular localization mediated by ligand binding to its C1 domain
Authors: Caloca, MJ Garcia-Bermejo, ML Blumberg, PM Lewin, NE Kremmer, E Mischak, H Wang, SM Nacro, K Bienfait, B Marquez, VE Kazanietz, MG
Citation: Mj. Caloca et al., beta 2-chimaerin is a novel target for diacylglycerol: Binding properties and changes in subcellular localization mediated by ligand binding to its C1 domain, P NAS US, 96(21), 1999, pp. 11854-11859
General and stereospecific route to 9-substituted, 8,9-disubstituted, and 9,10-disubstituted analogues of benzolactam-V8
Authors: Ma, DW Tang, TJ Kozikowski, AP Lewin, NE Blumberg, PM
Citation: Dw. Ma et al., General and stereospecific route to 9-substituted, 8,9-disubstituted, and 9,10-disubstituted analogues of benzolactam-V8, J ORG CHEM, 64(17), 1999, pp. 6366-6373
Probing the binding of indolactam-V to protein kinase C through site-directed mutagenesis and computational docking simulations
Authors: Wang, SM Liu, M Lewin, NE Lorenzo, PS Bhattacharrya, D Qiao, LX Kozikowski, AP Blumberg, PM
Citation: Sm. Wang et al., Probing the binding of indolactam-V to protein kinase C through site-directed mutagenesis and computational docking simulations, J MED CHEM, 42(18), 1999, pp. 3436-3446
Synthesis and biological evaluation of highly functionalized analogues of ingenol
Authors: Winkler, JD Kim, SH Harrison, S Lewin, NE Blumberg, PM
Citation: Jd. Winkler et al., Synthesis and biological evaluation of highly functionalized analogues of ingenol, J AM CHEM S, 121(2), 1999, pp. 296-300
Conformationally constrained analogues of diacylglycerol (DAG). 15. The indispensable role of the sn-1 and sn-2 carbonyls in the binding of DAG-lactones to protein kinase C (PK-C)
Authors: Benzaria, S Bienfait, B Nacro, K Wang, SM Lewin, NE Beheshti, M Blumberg, PM Marquez, VE
Citation: S. Benzaria et al., Conformationally constrained analogues of diacylglycerol (DAG). 15. The indispensable role of the sn-1 and sn-2 carbonyls in the binding of DAG-lactones to protein kinase C (PK-C), BIOORG MED, 8(23), 1998, pp. 3403-3408
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