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Results: 1-25 | 26-33
Results: 1-25/33
Low pH modulation of recombinant vanilloid receptors and perivascular capsaicin-sensitive sensory neurotransmission
Authors: Ralevic, V Kendall, DA Jerman, JC Davis, JB Middlemiss, DN Smart, D
Citation: V. Ralevic et al., Low pH modulation of recombinant vanilloid receptors and perivascular capsaicin-sensitive sensory neurotransmission, AUTON NEURO, 88(1-2), 2001, pp. 36-44
Quantitative mRNA analysis of five C-terminal splice variants of the human5-HT4 receptor in the central nervous system by TaqMan real time RT-PCR
Authors: Medhurst, AD Lezoualc'h, F Fischmeister, R Middlemiss, DN Sanger, GJ
Citation: Ad. Medhurst et al., Quantitative mRNA analysis of five C-terminal splice variants of the human5-HT4 receptor in the central nervous system by TaqMan real time RT-PCR, MOL BRAIN R, 90(2), 2001, pp. 125-134
SB-243213; a selective 5-HT2C receptor inverse agonist with improved anxiolytic profile: lack of tolerance and withdrawal anxiety
Authors: Wood, MD Reavill, C Trail, B Wilson, A Stean, T Kennett, GA Lightowler, S Blackburn, TP Thomas, D Gager, TL Riley, G Holland, V Bromidge, SM Forbes, IT Middlemiss, DN
Citation: Md. Wood et al., SB-243213; a selective 5-HT2C receptor inverse agonist with improved anxiolytic profile: lack of tolerance and withdrawal anxiety, NEUROPHARM, 41(2), 2001, pp. 186-199
Cannabinoid activation of recombinant and endogenous vanilloid receptors
Authors: Ralevic, V Kendall, DA Jerman, JC Middlemiss, DN Smart, D
Citation: V. Ralevic et al., Cannabinoid activation of recombinant and endogenous vanilloid receptors, EUR J PHARM, 424(3), 2001, pp. 211-219
Pharmacological characterisation of human 5-HT2 receptor subtypes
Authors: Jerman, JC Brough, SJ Gager, T Wood, M Coldwell, MC Smart, D Middlemiss, DN
Citation: Jc. Jerman et al., Pharmacological characterisation of human 5-HT2 receptor subtypes, EUR J PHARM, 414(1), 2001, pp. 23-30
SB-272183, a selective 5-HT1A, 5-HT1B and 5-HT1D receptor antagonist in native tissue
Authors: Watson, J Roberts, C Scott, C Kendall, I Collin, L Day, NC Harries, MH Soffin, E Davies, CH Randall, AD Heightman, T Gaster, L Wyman, P Parker, C Price, GW Middlemiss, DN
Citation: J. Watson et al., SB-272183, a selective 5-HT1A, 5-HT1B and 5-HT1D receptor antagonist in native tissue, BR J PHARM, 133(6), 2001, pp. 797-806
The effect of SB-269970, a 5-HT7 receptor antagonist, on 5-HT release fromserotonergic terminals and cell bodies
Authors: Roberts, C Allen, L Langmead, CJ Hagan, JJ Middlemiss, DN Price, GW
Citation: C. Roberts et al., The effect of SB-269970, a 5-HT7 receptor antagonist, on 5-HT release fromserotonergic terminals and cell bodies, BR J PHARM, 132(7), 2001, pp. 1574-1580
1-[2-[(heteroaryloxy)heteroaryl]carbamoyl]indolines: Novel and selective 5-HT2C receptor inverse agonists with potential as antidepressant/anxiolyticagents
Authors: Bromidge, SM Dabbs, S Davies, S Duckworth, DM Forbes, IT Jones, GE Jones, J King, FD Saunders, DV Blackburn, TP Holland, V Kennett, GA Lightowler, S Middlemiss, DN Riley, GJ Trail, B Wood, MD
Citation: Sm. Bromidge et al., 1-[2-[(heteroaryloxy)heteroaryl]carbamoyl]indolines: Novel and selective 5-HT2C receptor inverse agonists with potential as antidepressant/anxiolyticagents, BIOORG MED, 10(16), 2000, pp. 1863-1866
1-[2-[(heteroarylmethoxy)aryl]carbamoyl]indolines are selective and orallyactive 5-HT2C receptor inverse agonists
Authors: Bromidge, SM Davies, S Duckworth, DM Forbes, IT Jones, GE Jones, J King, FD Blackburn, TP Holland, V Kennett, GA Lightowler, S Middlemiss, DN Riley, GJ Trail, B Wood, MD
Citation: Sm. Bromidge et al., 1-[2-[(heteroarylmethoxy)aryl]carbamoyl]indolines are selective and orallyactive 5-HT2C receptor inverse agonists, BIOORG MED, 10(16), 2000, pp. 1867-1870
Cloning and characterization of human NTT5 and v7-3: Two orphan transporters of the Na+/Cl--dependent neurotransmitter transporter gene family
Authors: Farmer, MK Robbins, MJ Medhurst, AD Campbell, DA Ellington, K Duckworth, M Brown, AM Middlemiss, DN Price, GW Pangalos, MN
Citation: Mk. Farmer et al., Cloning and characterization of human NTT5 and v7-3: Two orphan transporters of the Na+/Cl--dependent neurotransmitter transporter gene family, GENOMICS, 70(2), 2000, pp. 241-252
Molecular cloning and characterization of two novel retinoic acid-inducible orphan G-protein-coupled receptors (GPRC5B and GPRC5C)
Authors: Robbins, MJ Michalovich, D Hill, J Calver, AR Medhurst, AD Gloger, I Sims, M Middlemiss, DN Pangalos, MN
Citation: Mj. Robbins et al., Molecular cloning and characterization of two novel retinoic acid-inducible orphan G-protein-coupled receptors (GPRC5B and GPRC5C), GENOMICS, 67(1), 2000, pp. 8-18
The expression of GABA(B1) and GABA(B2) receptor subunits in the CNS differs from that in peripheral tissues
Authors: Calver, AR Medhurst, AD Robbins, MJ Charles, KJ Evans, ML Harrison, DC Stammers, M Hughes, SA Hervieu, G Couve, A Moss, SJ Middlemiss, DN Pangalos, MN
Citation: Ar. Calver et al., The expression of GABA(B1) and GABA(B2) receptor subunits in the CNS differs from that in peripheral tissues, NEUROSCIENC, 100(1), 2000, pp. 155-170
The effect of SB-236057-A, a selective 5-HT1B receptor inverse agonist, onin vivo extracellular 5-HT levels in the freely-moving guinea-pig
Authors: Roberts, C Hatcher, P Hagan, JJ Austin, NE Jeffrey, P Wyman, P Gaster, LM Routledge, C Middlemiss, DN
Citation: C. Roberts et al., The effect of SB-236057-A, a selective 5-HT1B receptor inverse agonist, onin vivo extracellular 5-HT levels in the freely-moving guinea-pig, N-S ARCH PH, 362(2), 2000, pp. 177-183
Pharmacological actions of a novel, high-affinity, and selective human dopamine D-3 receptor antagonist, SB-277011-A
Authors: Reavill, C Taylor, SG Wood, MD Ashmeade, T Austin, NE Avenell, KY Boyfield, I Branch, CL Cilia, J Coldwell, MC Hadley, MS Hunter, AJ Jeffrey, P Jewitt, F Johnson, CN Jones, DNC Medhurst, AD Middlemiss, DN Nash, DJ Riley, GJ Routledge, C Stemp, G Thewlis, KM Trail, B Vong, AKK Hagan, JJ
Citation: C. Reavill et al., Pharmacological actions of a novel, high-affinity, and selective human dopamine D-3 receptor antagonist, SB-277011-A, J PHARM EXP, 294(3), 2000, pp. 1154-1165
Acute and chronic administration of the selective D-3 receptor antagonist SB-277011-A alters activity of midbrain dopamine neurons in rats: An in vivo electrophysiological study
Authors: Ashby, CR Minabe, Y Stemp, G Hagan, JJ Middlemiss, DN
Citation: Cr. Ashby et al., Acute and chronic administration of the selective D-3 receptor antagonist SB-277011-A alters activity of midbrain dopamine neurons in rats: An in vivo electrophysiological study, J PHARM EXP, 294(3), 2000, pp. 1166-1174
Design and synthesis of trans-N-[4-[2-(6-cyano-1,2,3,4-tetrahydroisoquinolin-2-yl)ethyl]cyclohexyl]-4-quinolinecarboxamide (SB-277011): A potent and selective dopamine D-3 receptor antagonist with high oral bioavailability and CNS penetration in the rat
Authors: Stemp, G Ashmeade, T Branch, CL Hadley, MS Hunter, AJ Johnson, CN Nash, DJ Thewlis, KM Vong, AKK Austin, NE Jeffrey, P Avenell, KY Boyfield, I Hagan, JJ Middlemiss, DN Reavill, C Riley, GJ Routledge, C Wood, M
Citation: G. Stemp et al., Design and synthesis of trans-N-[4-[2-(6-cyano-1,2,3,4-tetrahydroisoquinolin-2-yl)ethyl]cyclohexyl]-4-quinolinecarboxamide (SB-277011): A potent and selective dopamine D-3 receptor antagonist with high oral bioavailability and CNS penetration in the rat, J MED CHEM, 43(9), 2000, pp. 1878-1885
Biarylcarbamoylindolines are novel and selective 5-HT2C receptor inverse agonists: Identification of 5-methyl-1-[[2-[(2-methyl-3-pyridyl)oxy]-5-pyridyl]carbamoyl]-6-trifluoromethylindoline (SB-243213) as a potential antidepressant/anxiolytic agent
Authors: Bromidge, SM Dabbs, S Davies, DT Davies, S Duckworth, DM Forbes, IT Gaster, LM Ham, P Jones, GE King, FD Mulholland, KR Saunders, DV Wyman, PA Blaney, FE Clarke, SE Blackburn, TP Holland, V Kennett, GA Lightowler, S Middlemiss, DN Trail, B Riley, GJ Wood, MD
Citation: Sm. Bromidge et al., Biarylcarbamoylindolines are novel and selective 5-HT2C receptor inverse agonists: Identification of 5-methyl-1-[[2-[(2-methyl-3-pyridyl)oxy]-5-pyridyl]carbamoyl]-6-trifluoromethylindoline (SB-243213) as a potential antidepressant/anxiolytic agent, J MED CHEM, 43(6), 2000, pp. 1123-1134
A novel, potent, and selective 5-HT7 antagonist: (R)-3-(2-(2-(4-methylpiperidin-1-yl)-ethyl)pyrrolidine-1-sulfonyl)phenol (SB-269970)
Authors: Lovell, PJ Bromidge, SM Dabbs, S Duckworth, DM Forbes, IT Jennings, AJ King, FD Middlemiss, DN Rahman, SK Saunders, DV Collin, LL Hagan, JJ Riley, GJ Thomas, DR
Citation: Pj. Lovell et al., A novel, potent, and selective 5-HT7 antagonist: (R)-3-(2-(2-(4-methylpiperidin-1-yl)-ethyl)pyrrolidine-1-sulfonyl)phenol (SB-269970), J MED CHEM, 43(3), 2000, pp. 342-345
Characterization of [I-125]-SB-258585 binding to human recombinant and native 5-HT6 receptors in rat, pig and human brain tissue
Authors: Hirst, WD Minton, JAL Bromidge, SM Moss, SF Latter, AJ Riley, G Routledge, C Middlemiss, DN Price, GW
Citation: Wd. Hirst et al., Characterization of [I-125]-SB-258585 binding to human recombinant and native 5-HT6 receptors in rat, pig and human brain tissue, BR J PHARM, 130(7), 2000, pp. 1597-1605
Characterization of SB-271046: A potent, selective and orally active 5-HT6receptor antagonist
Authors: Routledge, C Bromidge, SM Moss, SF Price, GW Hirst, W Newman, H Riley, G Gager, T Stean, T Upton, N Clarke, SE Brown, AM Middlemiss, DN
Citation: C. Routledge et al., Characterization of SB-271046: A potent, selective and orally active 5-HT6receptor antagonist, BR J PHARM, 130(7), 2000, pp. 1606-1612
Characterization of SB-269970-A, a selective 5-HT7 receptor antagonist
Authors: Hagan, JJ Price, GW Jeffrey, P Deeks, NJ Stean, T Piper, D Smith, MI Upton, N Medhurst, AD Middlemiss, DN Riley, GJ Lovell, PJ Bromidge, SM Thomas, DR
Citation: Jj. Hagan et al., Characterization of SB-269970-A, a selective 5-HT7 receptor antagonist, BR J PHARM, 130(3), 2000, pp. 539-548
[H-3]-SB-269970 - A selective antagonist radioligand for 5-HT7 receptors
Authors: Thomas, DR Atkinson, PJ Ho, M Bromidge, SM Lovell, PJ Villani, AJ Hagan, JJ Middlemiss, DN Price, GW
Citation: Dr. Thomas et al., [H-3]-SB-269970 - A selective antagonist radioligand for 5-HT7 receptors, BR J PHARM, 130(2), 2000, pp. 409-417
Enhancement of 5-HT1B and 5-HT1D receptor antagonist effects on extracellular 5-HT levels in the guinea-pig brain following concurrent 5-HT1A or 5-HTre-uptake site blockade
Authors: Roberts, C Boyd, DF Middlemiss, DN Routledge, C
Citation: C. Roberts et al., Enhancement of 5-HT1B and 5-HT1D receptor antagonist effects on extracellular 5-HT levels in the guinea-pig brain following concurrent 5-HT1A or 5-HTre-uptake site blockade, NEUROPHARM, 38(9), 1999, pp. 1409-1419
5-chloro-N-(4-methoxy-3-piperazin-1-yl-phenyl)-3-methyl-2-benzothiophenesulfonamide (SB-271046): A potent, selective, and orally bioavailable 5-HT6 receptor antagonist
Authors: Bromidge, SM Brown, AM Clarke, SE Dodgson, K Gager, T Grassam, HL Jeffrey, PM Joiner, GF King, FD Middlemiss, DN Moss, SF Newman, H Riley, G Routledge, C Wyman, P
Citation: Sm. Bromidge et al., 5-chloro-N-(4-methoxy-3-piperazin-1-yl-phenyl)-3-methyl-2-benzothiophenesulfonamide (SB-271046): A potent, selective, and orally bioavailable 5-HT6 receptor antagonist, J MED CHEM, 42(2), 1999, pp. 202-205
SB-236057, a selective 5-HT1B receptor inverse agonist, blocks the 5-HT human terminal autoreceptor
Authors: Middlemiss, DN Gothert, M Schlicker, E Scott, CM Selkirk, JV Watson, J Gaster, LM Wyman, P Riley, G Price, GW
Citation: Dn. Middlemiss et al., SB-236057, a selective 5-HT1B receptor inverse agonist, blocks the 5-HT human terminal autoreceptor, EUR J PHARM, 375(1-3), 1999, pp. 359-365
Risultati: 1-25 | 26-33