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Results: 1-11 |
Results: 11
Inhibition of (cytosine C5)-methyltransferase by oligonucleotides containing flexible (cyclopentane) and conformationally constrained (bicyclo[3.1.0]hexane) abasic sites
Authors: Marquez, VE Wang, PY Nicklaus, MC Maier, M Manoharan, M Christman, JK Banavali, NK Mackerell, AD
Citation: Ve. Marquez et al., Inhibition of (cytosine C5)-methyltransferase by oligonucleotides containing flexible (cyclopentane) and conformationally constrained (bicyclo[3.1.0]hexane) abasic sites, NUCLEOS NUC, 20(4-7), 2001, pp. 451-459
Comparison of the NCI open database with seven large chemical structural databases
Authors: Voigt, JH Bienfait, B Wang, SM Nicklaus, MC
Citation: Jh. Voigt et al., Comparison of the NCI open database with seven large chemical structural databases, J CHEM INF, 41(3), 2001, pp. 702-712
Conformationally constrained analogues of diacylglycerol. 18. The incorporation of a hydroxamate moiety into diacylglycerol-lactones reduces lipophilicity and helps discriminate between sn-1 and sn-2 binding modes to proteinkinase c (PK-C). Implications for isozyme specificity
Authors: Lee, J Han, KC Kang, JH Pearce, LL Lewin, NE Yan, SQ Benzaria, S Nicklaus, MC Blumberg, PM Marquez, VE
Citation: J. Lee et al., Conformationally constrained analogues of diacylglycerol. 18. The incorporation of a hydroxamate moiety into diacylglycerol-lactones reduces lipophilicity and helps discriminate between sn-1 and sn-2 binding modes to proteinkinase c (PK-C). Implications for isozyme specificity, J MED CHEM, 44(25), 2001, pp. 4309-4312
An optimized protein kinase C activating diacylglycerol combining high binding affinity (K-i) with reduced lipophilicity (log P)
Authors: Nacro, K Sigano, DM Yan, SQ Nicklaus, MC Pearce, LL Lewin, NE Garfield, SH Blumberg, PM Marquez, VE
Citation: K. Nacro et al., An optimized protein kinase C activating diacylglycerol combining high binding affinity (K-i) with reduced lipophilicity (log P), J MED CHEM, 44(12), 2001, pp. 1892-1904
Identification of HIV-1 integrase inhibitors via three-dimensional database searching using ASV and HIV-1 integrases as targets
Authors: Chen, IJ Neamati, N Nicklaus, MC Orr, A Anderson, L Barchi, JJ Kelley, JA Pommier, Y MacKerell, AD
Citation: Ij. Chen et al., Identification of HIV-1 integrase inhibitors via three-dimensional database searching using ASV and HIV-1 integrases as targets, BIO MED CH, 8(10), 2000, pp. 2385-2398
Interactions of conformationally biased north and south 2 '-fluoro-2 ',3 '-dideoxynucleoside 5 '-triphosphates with the active site of HIV-1 reverse transcriptase
Authors: Mu, L Sarafianos, SG Nicklaus, MC Russ, P Siddiqui, MA Ford, H Mitsuya, H Le, R Kodama, E Meier, C Knispel, T Anderson, L Barchi, JJ Marquez, VE
Citation: L. Mu et al., Interactions of conformationally biased north and south 2 '-fluoro-2 ',3 '-dideoxynucleoside 5 '-triphosphates with the active site of HIV-1 reverse transcriptase, BIOCHEM, 39(37), 2000, pp. 11205-11215
Adenosine deaminase prefers a distinct sugar ring conformation for bindingand catalysis: Kinetic and structural studies
Authors: Ford, H Dai, F Mu, L Siddiqui, MA Nicklaus, MC Anderson, L Marquez, VE Barchi, JJ
Citation: H. Ford et al., Adenosine deaminase prefers a distinct sugar ring conformation for bindingand catalysis: Kinetic and structural studies, BIOCHEM, 39(10), 2000, pp. 2581-2592
Use of oligodeoxyribonucleotides with conformationally constrained abasic sugar targets to probe the mechanism of base flipping by HhaI DNA (cytosineC5)-methyltransferase
Authors: Wang, PY Brank, AS Banavali, NK Nicklaus, MC Marquez, VE Christman, JK MacKerell, AD
Citation: Py. Wang et al., Use of oligodeoxyribonucleotides with conformationally constrained abasic sugar targets to probe the mechanism of base flipping by HhaI DNA (cytosineC5)-methyltransferase, J AM CHEM S, 122(50), 2000, pp. 12422-12434
Conformationally restricted nucleosides. The reaction of adenosine deaminase with substrates built on a bicyclo[3.1.0]hexane template
Authors: Marquez, VE Russ, P Alonso, R Siddiqui, MA Shin, KJ George, C Nicklaus, MC Dai, F Ford, H
Citation: Ve. Marquez et al., Conformationally restricted nucleosides. The reaction of adenosine deaminase with substrates built on a bicyclo[3.1.0]hexane template, NUCLEOS NUC, 18(4-5), 1999, pp. 521-530
Mutation of a conserved serine residue in a quinolone-resistant type II topoisomerase alters the enzyme-DNA and drug interactions
Authors: Strumberg, D Nitiss, JL Rose, A Nicklaus, MC Pommier, Y
Citation: D. Strumberg et al., Mutation of a conserved serine residue in a quinolone-resistant type II topoisomerase alters the enzyme-DNA and drug interactions, J BIOL CHEM, 274(11), 1999, pp. 7292-7301
Synthesis of conformationally restricted carbocyclic nucleosides: The roleof the O(4 ')-atom in the key hydration step of adenosine deaminase
Authors: Marquez, VE Russ, P Alonso, R Siddiqui, MA Hernandez, S George, C Nicklaus, MC Dai, F Ford, H
Citation: Ve. Marquez et al., Synthesis of conformationally restricted carbocyclic nucleosides: The roleof the O(4 ')-atom in the key hydration step of adenosine deaminase, HELV CHIM A, 82(12), 1999, pp. 2119-2129
Risultati: 1-11 |