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Results: 1-25 | 26-26
Results: 1-25/26
Pharmacological evidence for a 7-benzylidenenaltrexone-preferring opioid receptor mediating the inhibitory actions of peptidic delta- and mu-opioid agonists on neurogenic ion transport in porcine ileal mucosa
Authors: Poonyachoti, S Portoghese, PS Brown, DR
Citation: S. Poonyachoti et al., Pharmacological evidence for a 7-benzylidenenaltrexone-preferring opioid receptor mediating the inhibitory actions of peptidic delta- and mu-opioid agonists on neurogenic ion transport in porcine ileal mucosa, J PHARM EXP, 297(2), 2001, pp. 672-679
Characterization of opioid receptors modulating neurogenic contractions ofcircular muscle from porcine ileum and evidence that delta- and kappa-opioid receptors are coexpressed in myenteric neurons
Authors: Poonyachoti, S Portoghese, PS Brown, DR
Citation: S. Poonyachoti et al., Characterization of opioid receptors modulating neurogenic contractions ofcircular muscle from porcine ileum and evidence that delta- and kappa-opioid receptors are coexpressed in myenteric neurons, J PHARM EXP, 297(1), 2001, pp. 69-77
Covalently induced activation of the delta opioid receptor by a fluorogenic affinity label, 7 '-(phthalaldehyde-carboxamido)naltrindole (PNTI)
Authors: Le Bourdonnec, B El Kouhen, R Poda, G Law, PY Loh, HH Ferguson, DM Portoghese, PS
Citation: B. Le Bourdonnec et al., Covalently induced activation of the delta opioid receptor by a fluorogenic affinity label, 7 '-(phthalaldehyde-carboxamido)naltrindole (PNTI), J MED CHEM, 44(7), 2001, pp. 1017-1020
Investigation of the selectivity of oxymorphone- and naltrexone-derived ligands via site-directed mutagenesis of opioid receptors: Exploring the 'address' recognition locus
Authors: Metzger, TG Paterlini, MG Ferguson, DM Portoghese, PS
Citation: Tg. Metzger et al., Investigation of the selectivity of oxymorphone- and naltrexone-derived ligands via site-directed mutagenesis of opioid receptors: Exploring the 'address' recognition locus, J MED CHEM, 44(6), 2001, pp. 857-862
Alfred Burger Award address in medicinal chemistry. From models to molecules: Opioid receptor dimers, bivalent ligands, and selective opioid receptorprobes. (vol 44, pg 2266, 2001)
Authors: Portoghese, PS
Citation: Ps. Portoghese, Alfred Burger Award address in medicinal chemistry. From models to molecules: Opioid receptor dimers, bivalent ligands, and selective opioid receptorprobes. (vol 44, pg 2266, 2001), J MED CHEM, 44(22), 2001, pp. 3758-3758
From models to molecules: Opioid receptor dimers, bivalent ligands, and selective opioid receptor probes
Authors: Portoghese, PS
Citation: Ps. Portoghese, From models to molecules: Opioid receptor dimers, bivalent ligands, and selective opioid receptor probes, J MED CHEM, 44(14), 2001, pp. 2259-2269
Transformation of a kappa-opioid receptor antagonist to a kappa-agonist bytransfer of a guanidinium group from the 5 '- to 6 '-position of naltrindole
Authors: Sharma, SK Jones, RM Metzger, TG Ferguson, DM Portoghese, PS
Citation: Sk. Sharma et al., Transformation of a kappa-opioid receptor antagonist to a kappa-agonist bytransfer of a guanidinium group from the 5 '- to 6 '-position of naltrindole, J MED CHEM, 44(13), 2001, pp. 2073-2079
The kappa-opioid antagonist GNTI reduces U50,488-, DAMGO-, and deprivation-induced feeding, but not butorphanol- and neuropeptide Y-induced feeding in rats
Authors: Jewett, DC Grace, MK Jones, RM Billington, CJ Portoghese, PS Levine, AS
Citation: Dc. Jewett et al., The kappa-opioid antagonist GNTI reduces U50,488-, DAMGO-, and deprivation-induced feeding, but not butorphanol- and neuropeptide Y-induced feeding in rats, BRAIN RES, 909(1-2), 2001, pp. 75-80
kappa-opioid receptor agonist suppression of HIV-1 expression in CD4(+) lymphocytes
Authors: Peterson, PK Gekker, G Lokensgard, JR Bidlack, JM Chang, AC Fang, XG Portoghese, PS
Citation: Pk. Peterson et al., kappa-opioid receptor agonist suppression of HIV-1 expression in CD4(+) lymphocytes, BIOCH PHARM, 61(9), 2001, pp. 1145-1151
Investigation of phenolic bioisosterism in opiates: 3-sulfonamido analogues of naltrexone and oxymorphone
Authors: McCurdy, CR Jones, RM Portoghese, PS
Citation: Cr. Mccurdy et al., Investigation of phenolic bioisosterism in opiates: 3-sulfonamido analogues of naltrexone and oxymorphone, ORG LETT, 2(6), 2000, pp. 819-821
Morphine tolerance in mice changes response of heroin from mu to delta opioid receptors
Authors: Rady, JJ Holmes, BB Portoghese, PS Fujimoto, JM
Citation: Jj. Rady et al., Morphine tolerance in mice changes response of heroin from mu to delta opioid receptors, P SOC EXP M, 224(2), 2000, pp. 93-101
Binding of norbinaltorphimine (norBNI) congeners to wild-type and mutant mu and kappa opioid receptors: Molecular recognition loci for the pharmacophore and address components of kappa antagonists
Authors: Larson, DL Jones, RM Hjorth, SA Schwartz, TW Portoghese, PS
Citation: Dl. Larson et al., Binding of norbinaltorphimine (norBNI) congeners to wild-type and mutant mu and kappa opioid receptors: Molecular recognition loci for the pharmacophore and address components of kappa antagonists, J MED CHEM, 43(8), 2000, pp. 1573-1576
Isosteric replacement of acidic with neutral residues in extracellular loop-2 of the kappa-opioid receptor does not affect dynorphin A(1-13) affinityand function
Authors: Ferguson, DM Kramer, S Metzger, TG Law, PY Portoghese, PS
Citation: Dm. Ferguson et al., Isosteric replacement of acidic with neutral residues in extracellular loop-2 of the kappa-opioid receptor does not affect dynorphin A(1-13) affinityand function, J MED CHEM, 43(7), 2000, pp. 1251-1252
Molecular docking reveals a novel binding site model for fentanyl at the mu-opioid receptor
Authors: Subramanian, G Paterlini, MG Portoghese, PS Ferguson, DM
Citation: G. Subramanian et al., Molecular docking reveals a novel binding site model for fentanyl at the mu-opioid receptor, J MED CHEM, 43(3), 2000, pp. 381-391
Potent and selective indolomorphinan antagonists of the kappa-opioid receptor
Authors: Stevens, WC Jones, RM Subramanian, G Metzger, TG Ferguson, DM Portoghese, PS
Citation: Wc. Stevens et al., Potent and selective indolomorphinan antagonists of the kappa-opioid receptor, J MED CHEM, 43(14), 2000, pp. 2759-2769
Reporter affinity labels: An o-phthalaldehyde derivative of beta-naltrexamine as a fluorogenic ligand for opioid receptors
Authors: Le Bourdonnec, B El Kouhen, R Lunzer, MM Law, PY Loh, HH Portoghese, PS
Citation: B. Le Bourdonnec et al., Reporter affinity labels: An o-phthalaldehyde derivative of beta-naltrexamine as a fluorogenic ligand for opioid receptors, J MED CHEM, 43(13), 2000, pp. 2489-2492
GRAS flavoring substances 19
Authors: Newberne, P Smith, RL Doull, J Feron, VJ Goodman, JI Munro, IC Portoghese, PS Waddell, WJ Wagner, BM Weil, CS Adams, TB Hallagan, JB
Citation: P. Newberne et al., GRAS flavoring substances 19, FOOD TECHN, 54(6), 2000, pp. 66
5 '-guanidinonaltrindole, a highly selective and potent kappa-opioid receptor antagonist
Authors: Jones, RM Portoghese, PS
Citation: Rm. Jones et Ps. Portoghese, 5 '-guanidinonaltrindole, a highly selective and potent kappa-opioid receptor antagonist, EUR J PHARM, 396(1), 2000, pp. 49-52
Stereochemical requirements for receptor recognition of the mu-opioid peptide endomorphin-1
Authors: Paterlini, MG Avitabile, F Ostrowski, BG Ferguson, DM Portoghese, PS
Citation: Mg. Paterlini et al., Stereochemical requirements for receptor recognition of the mu-opioid peptide endomorphin-1, BIOPHYS J, 78(2), 2000, pp. 590-599
The delta(2)-opioid receptor antagonist naltriben reduces motivated responding for ethanol
Authors: June, HL McCane, SR Zink, RW Portoghese, PS Li, TK Froehlich, JC
Citation: Hl. June et al., The delta(2)-opioid receptor antagonist naltriben reduces motivated responding for ethanol, PSYCHOPHAR, 147(1), 1999, pp. 81-89
The FEMA GRAS assessment of trans-anethole used as a flavouring substance
Authors: Newberne, P Smith, RL Doull, J Goodman, JI Munro, IC Portoghese, PS Wagner, BM Weil, CS Woods, LA Adams, TB Lucas, CD Ford, RA
Citation: P. Newberne et al., The FEMA GRAS assessment of trans-anethole used as a flavouring substance, FOOD CHEM T, 37(7), 1999, pp. 789-811
Endomorphin-1 potentiates HIV-1 expression in human brain cell cultures: implication of an atypical mu-opioid receptor
Authors: Peterson, PK Gekker, G Hu, SX Lokensgard, J Portoghese, PS Chao, CC
Citation: Pk. Peterson et al., Endomorphin-1 potentiates HIV-1 expression in human brain cell cultures: implication of an atypical mu-opioid receptor, NEUROPHARM, 38(2), 1999, pp. 273-278
A flexible policy concerning purity criteria for published target compounds
Authors: Portoghese, PS
Citation: Ps. Portoghese, A flexible policy concerning purity criteria for published target compounds, J MED CHEM, 42(24), 1999, pp. 4927-4927
Impact of recombinant DNA technology and molecular modeling on the practice of medicinal chemistry: Structure-activity analysis of opioid ligands
Authors: Portoghese, PS
Citation: Ps. Portoghese, Impact of recombinant DNA technology and molecular modeling on the practice of medicinal chemistry: Structure-activity analysis of opioid ligands, AM J PHAR E, 63(3), 1999, pp. 342-347
Mutational evidence for a common kappa antagonist binding pocket in the wild-type kappa and mutant mu[K303E] opioid receptors
Authors: Jones, RM Hjorth, SA Schwartz, TW Portoghese, PS
Citation: Rm. Jones et al., Mutational evidence for a common kappa antagonist binding pocket in the wild-type kappa and mutant mu[K303E] opioid receptors, J MED CHEM, 41(25), 1998, pp. 4911-4914
Risultati: 1-25 | 26-26