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Results: 1-20 |
Results: 20
Engineering of a functional human NADH-dependent cytochrome P450 system
Authors: Dohr, O Paine, MJI Friedberg, T Roberts, GCK Wolf, CR
Citation: O. Dohr et al., Engineering of a functional human NADH-dependent cytochrome P450 system, P NAS US, 98(1), 2001, pp. 81-86
Structure-activity relationships in flexible protein domains: Regulation of rho GTPases by RhoGDI and D4 GDI
Authors: Golovanov, AP Chuang, TH DerMardirossian, C Barsukov, I Hawkins, D Badii, R Bokoch, GM Lian, LY Roberts, GCK
Citation: Ap. Golovanov et al., Structure-activity relationships in flexible protein domains: Regulation of rho GTPases by RhoGDI and D4 GDI, J MOL BIOL, 305(1), 2001, pp. 121-135
Thiomandelic acid, a broad spectrum inhibitor of zinc beta-lactamases - Kinetic and spectroscopic studies
Authors: Mollard, C Moali, C Papamicael, C Damblon, C Vessilier, S Amicosante, G Schofield, CJ Galleni, M Frere, JM Roberts, GCK
Citation: C. Mollard et al., Thiomandelic acid, a broad spectrum inhibitor of zinc beta-lactamases - Kinetic and spectroscopic studies, J BIOL CHEM, 276(48), 2001, pp. 45015-45023
Structural consequences of site-directed mutagenesis in flexible protein domains - NMR characterization of the L(55,56)S mutant of RhoGDI
Authors: Golovanov, AP Hawkins, D Barsukov, I Badii, R Bokoch, GM Lian, LY Roberts, GCK
Citation: Ap. Golovanov et al., Structural consequences of site-directed mutagenesis in flexible protein domains - NMR characterization of the L(55,56)S mutant of RhoGDI, EUR J BIOCH, 268(8), 2001, pp. 2253-2260
Structure and folding of glutathione S-transferase A1-1: structural transition and ligand interactions
Authors: Lian, LY Allardyce, CS Moody, PCE Roberts, GCK
Citation: Ly. Lian et al., Structure and folding of glutathione S-transferase A1-1: structural transition and ligand interactions, CHEM-BIO IN, 133(1-3), 2001, pp. 13-16
Stopped-flow kinetic studies of flavin reduction in human cytochrome P450 reductase and its component domains
Authors: Gutierrez, A Lian, LY Wolf, CR Scrutton, NS Roberts, GCK
Citation: A. Gutierrez et al., Stopped-flow kinetic studies of flavin reduction in human cytochrome P450 reductase and its component domains, BIOCHEM, 40(7), 2001, pp. 1964-1975
Role of the conserved phenylalanine 181 of NADPH-cytochrome p450 oxidoreductase in FMN binding and catalytic activity
Authors: Paine, MJI Ayivor, S Munro, A Tsan, P Lian, LY Roberts, GCK Wolf, CR
Citation: Mji. Paine et al., Role of the conserved phenylalanine 181 of NADPH-cytochrome p450 oxidoreductase in FMN binding and catalytic activity, BIOCHEM, 40(45), 2001, pp. 13439-13447
Dynamics of mononuclear cadmium beta-lactamase revealed by the combinationof NMR and PAC spectroscopy
Authors: Hemmingsen, L Damblon, C Antony, J Jensen, N Adolph, HW Wommer, S Roberts, GCK Bauer, R
Citation: L. Hemmingsen et al., Dynamics of mononuclear cadmium beta-lactamase revealed by the combinationof NMR and PAC spectroscopy, J AM CHEM S, 123(42), 2001, pp. 10329-10335
Applications of NMR in drug discovery
Authors: Roberts, GCK
Citation: Gck. Roberts, Applications of NMR in drug discovery, DRUG DISC T, 5(6), 2000, pp. 230-240
Mapping the binding site for the GTP-binding protein Rac-1 on its inhibitor RhoGDI-1
Authors: Lian, LY Barsukov, I Golovanov, AP Hawkins, DI Badii, R Sze, KH Keep, NH Bokoch, GM Roberts, GCK
Citation: Ly. Lian et al., Mapping the binding site for the GTP-binding protein Rac-1 on its inhibitor RhoGDI-1, STRUCT F D, 8(1), 2000, pp. 47-55
Trp-676 facilitates nicotinamide coenzyme exchange in the reductive half-reaction of human cytochrome P450 reductase: Properties of the soluble W676Rand W676A mutant reductases
Authors: Gutierrez, A Doehr, O Paine, M Wolf, CR Scrutton, NS Roberts, GCK
Citation: A. Gutierrez et al., Trp-676 facilitates nicotinamide coenzyme exchange in the reductive half-reaction of human cytochrome P450 reductase: Properties of the soluble W676Rand W676A mutant reductases, BIOCHEM, 39(51), 2000, pp. 15990-15999
Interaction of the lantibiotic nisin with mixed lipid bilayers: A P-31 andH-2 NMR study
Authors: Bonev, BB Chan, WC Bycroft, BW Roberts, GCK Watts, A
Citation: Bb. Bonev et al., Interaction of the lantibiotic nisin with mixed lipid bilayers: A P-31 andH-2 NMR study, BIOCHEM, 39(37), 2000, pp. 11425-11433
An unusual matrix of stereocomplementarity in the hydroxylation of monohydroxy fatty acids catalysed by cytochrome P-450 from Bacillus megaterium with potential application in biotransformations
Authors: Ahmed, F Al-Mutairi, EH Avery, KL Cullis, PM Primrose, WU Roberts, GCK Willis, CL
Citation: F. Ahmed et al., An unusual matrix of stereocomplementarity in the hydroxylation of monohydroxy fatty acids catalysed by cytochrome P-450 from Bacillus megaterium with potential application in biotransformations, CHEM COMMUN, (20), 1999, pp. 2049-2050
The power of evolution: accessing the synthetic potential of P450s
Authors: Roberts, GCK
Citation: Gck. Roberts, The power of evolution: accessing the synthetic potential of P450s, CHEM BIOL, 6(10), 1999, pp. R269-R272
Crystal structure of the FMN-binding domain of human cytochrome P450 reductase at 1.93 angstrom resolution
Authors: Zhao, Q Modi, S Smith, G Paine, M McDonagh, PD Wolf, CR Tew, D Lian, LY Roberts, GCK Driessen, HPC
Citation: Q. Zhao et al., Crystal structure of the FMN-binding domain of human cytochrome P450 reductase at 1.93 angstrom resolution, PROTEIN SCI, 8(2), 1999, pp. 298-306
NMR spectroscopy in structure-based drug design
Authors: Roberts, GCK
Citation: Gck. Roberts, NMR spectroscopy in structure-based drug design, CURR OPIN B, 10(1), 1999, pp. 42-47
The role of tyrosine-9 and the C-terminal helix in the catalytic mechanismof Alpha-class glutathione S-transferases
Authors: Allardyce, CS McDonagh, PD Lian, LY Wolf, CR Roberts, GCK
Citation: Cs. Allardyce et al., The role of tyrosine-9 and the C-terminal helix in the catalytic mechanismof Alpha-class glutathione S-transferases, BIOCHEM J, 343, 1999, pp. 525-531
Determinants of specificity for aflatoxin B-1-8,9-epoxide in Alpha-class glutathione S-transferases
Authors: McDonagh, PD Judah, DJ Hayes, JD Lian, LY Neal, GE Wolf, CR Roberts, GCK
Citation: Pd. Mcdonagh et al., Determinants of specificity for aflatoxin B-1-8,9-epoxide in Alpha-class glutathione S-transferases, BIOCHEM J, 339, 1999, pp. 95-101
Direct measurement of the pK(a) of aspartic acid 26 in Lactobacillus caseidihydrofolate reductase: Implications for the catalytic mechanism
Authors: Casarotto, MG Basran, J Badii, R Sze, KH Roberts, GCK
Citation: Mg. Casarotto et al., Direct measurement of the pK(a) of aspartic acid 26 in Lactobacillus caseidihydrofolate reductase: Implications for the catalytic mechanism, BIOCHEM, 38(25), 1999, pp. 8038-8044
H-1-N-15 HMQC for the identification of metal-bound histidines in Cd-113-substituted Bacillus cereus zinc beta-lactamase
Authors: Damblon, C Prosperi, C Lian, LY Barsukov, I Soto, RP Galleni, M Frere, JM Roberts, GCK
Citation: C. Damblon et al., H-1-N-15 HMQC for the identification of metal-bound histidines in Cd-113-substituted Bacillus cereus zinc beta-lactamase, J AM CHEM S, 121(49), 1999, pp. 11575-11576
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