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Results: 1-19 |
Results: 19
Inhibition of BCRP-mediated drug efflux by fumitremorgin-type indolyl diketopiperazines
Authors: van Loevezijn, A Allen, JD Schinkel, AH Koomen, GJ
Citation: A. Van Loevezijn et al., Inhibition of BCRP-mediated drug efflux by fumitremorgin-type indolyl diketopiperazines, BIOORG MED, 11(1), 2001, pp. 29-32
Bidirectional action of the Igf2r imprint control element on upstream and downstream imprinted genes
Authors: Zwart, R Sleutels, F Wutz, A Schinkel, AH Barlow, DP
Citation: R. Zwart et al., Bidirectional action of the Igf2r imprint control element on upstream and downstream imprinted genes, GENE DEV, 15(18), 2001, pp. 2361-2366
Reduced hepatic uptake and intestinal excretion of organic cations in micewith a targeted disruption of the organic cation transporter 1 (Oct1 [Slc22a1]) gene
Authors: Jonker, JW Wagenaar, E Mol, CAAM Buitelaar, M Koepsell, H Smit, JW Schinkel, AH
Citation: Jw. Jonker et al., Reduced hepatic uptake and intestinal excretion of organic cations in micewith a targeted disruption of the organic cation transporter 1 (Oct1 [Slc22a1]) gene, MOL CELL B, 21(16), 2001, pp. 5471-5477
P-glycoprotein limits oral availability, brain, and fetal penetration of saquinavir even with high doses of ritonavir
Authors: Huisman, MT Smit, JW Wiltshire, HR Hoetelmans, RMW Beijnen, JH Schinkel, AH
Citation: Mt. Huisman et al., P-glycoprotein limits oral availability, brain, and fetal penetration of saquinavir even with high doses of ritonavir, MOLEC PHARM, 59(4), 2001, pp. 806-813
Subcellular localization and distribution of the breast cancer resistance protein transporter in normal human tissues
Authors: Maliepaard, M Scheffer, GL Faneyte, IF van Gastelen, MA Pijnenborg, ACLM Schinkel, AH van de Vijver, MJ Scheper, RJ Schellens, JHM
Citation: M. Maliepaard et al., Subcellular localization and distribution of the breast cancer resistance protein transporter in normal human tissues, CANCER RES, 61(8), 2001, pp. 3458-3464
Role of breast cancer resistance protein in the bioavailability and fetal penetration of topotecan
Authors: Jonker, JW Smit, JW Brinkhuis, RF Maliepaard, M Beijnen, JH Schellens, JHM Schinkel, AH
Citation: Jw. Jonker et al., Role of breast cancer resistance protein in the bioavailability and fetal penetration of topotecan, J NAT CANC, 92(20), 2000, pp. 1651-1656
Modulation of oral bioavailability of anticancer drugs: from mouse to man
Authors: Schellens, JHM Malingre, MM Kruijtzer, CMF Bardelmeijer, HA van Tellingen, O Schinkel, AH Beijnen, JH
Citation: Jhm. Schellens et al., Modulation of oral bioavailability of anticancer drugs: from mouse to man, EUR J PH SC, 12(2), 2000, pp. 103-110
Significance of P-glycoprotein for the pharmacology and clinical use of HIV protease inhibitors
Authors: Huisman, MT Smit, JW Schinkel, AH
Citation: Mt. Huisman et al., Significance of P-glycoprotein for the pharmacology and clinical use of HIV protease inhibitors, AIDS, 14(3), 2000, pp. 237-242
Altered expression of hepatic cytochromes P-450 in mice deficient in one or more mdr1 genes. (vol 57, pg 188, 2000)
Authors: Schuetz, EG Umbenhauer, DR Yasuda, K Brimer, C Nguyen, L Relling, MV Schuetz, JD Schinkel, AH
Citation: Eg. Schuetz et al., Altered expression of hepatic cytochromes P-450 in mice deficient in one or more mdr1 genes. (vol 57, pg 188, 2000), MOLEC PHARM, 57(6), 2000, pp. NIL_1-NIL_1
Altered expression of hepatic cytochromes P-450 in mice deficient in one or more mdr1 genes
Authors: Schuetz, EG Umbenhauer, DR Yasuda, K Brimer, C Nguyen, L Relling, MV Schuetz, JD Schinkel, AH
Citation: Eg. Schuetz et al., Altered expression of hepatic cytochromes P-450 in mice deficient in one or more mdr1 genes, MOLEC PHARM, 57(1), 2000, pp. 188-197
Multidrug resistance protein 1 protects the choroid plexus epithelium and contributes to the blood-cerebrospinal fluid barrier
Authors: Wijnholds, J de Lange, ECM Scheffer, GL van den Berg, DJ Mol, CAAM van der Valk, M Schinkel, AH Scheper, RJ Breimer, DD Borst, P
Citation: J. Wijnholds et al., Multidrug resistance protein 1 protects the choroid plexus epithelium and contributes to the blood-cerebrospinal fluid barrier, J CLIN INV, 105(3), 2000, pp. 279-285
Extensive contribution of the multidrug transporters P-glycoprotein and Mrp1 to basal drug resistance
Authors: Allen, JD Brinkhuis, RF van Deemter, L Wijnholds, J Schinkel, AH
Citation: Jd. Allen et al., Extensive contribution of the multidrug transporters P-glycoprotein and Mrp1 to basal drug resistance, CANCER RES, 60(20), 2000, pp. 5761-5766
Transport mechanisms for cationic drugs and proteins in kidney, liver and intestine: implication for drug interactions and cell-specific drug delivery
Authors: Meijer, DKF Hooiveld, GJEJ Schinkel, AH van Montfoort, JE Haas, M de Zeeuw, D Moolenaar, F Smit, JW Meier, PJ
Citation: Dkf. Meijer et al., Transport mechanisms for cationic drugs and proteins in kidney, liver and intestine: implication for drug interactions and cell-specific drug delivery, NEPH DIAL T, 14, 1999, pp. 1-51
P-glycoprotein, a gatekeeper in the blood-brain barrier
Authors: Schinkel, AH
Citation: Ah. Schinkel, P-glycoprotein, a gatekeeper in the blood-brain barrier, ADV DRUG DE, 36(2-3), 1999, pp. 179-194
Comparative pharmacokinetics of vinblastine after a 96-hour continuous infusion in wild-type mice and mice lacking mdr1a P-glycoprotein
Authors: van Asperen, J van Tellingen, O Schinkel, AH Beijnen, JH
Citation: J. Van Asperen et al., Comparative pharmacokinetics of vinblastine after a 96-hour continuous infusion in wild-type mice and mice lacking mdr1a P-glycoprotein, J PHARM EXP, 289(1), 1999, pp. 329-333
Absence or pharmacological blocking of placental P-glycoprotein profoundlyincreases fetal drug exposure
Authors: Smit, JW Huisman, MT van Tellingen, O Wiltshire, HR Schinkel, AH
Citation: Jw. Smit et al., Absence or pharmacological blocking of placental P-glycoprotein profoundlyincreases fetal drug exposure, J CLIN INV, 104(10), 1999, pp. 1441-1447
The mouse Bcrp1/Mxr/Abcp gene: Amplification and overexpression in cell lines selected for resistance to topotecan, mitoxantrone, or doxorubicin
Authors: Allen, JD Brinkhuis, RF Wijnholds, J Schinkel, AH
Citation: Jd. Allen et al., The mouse Bcrp1/Mxr/Abcp gene: Amplification and overexpression in cell lines selected for resistance to topotecan, mitoxantrone, or doxorubicin, CANCER RES, 59(17), 1999, pp. 4237-4241
Role of blood-brain barrier P-glycoprotein in limiting brain accumulation and sedative side-effects of asimadoline, a peripherally acting analgaesic drug
Authors: Jonker, JW Wagenaar, E van Deemter, L Gottschlich, R Bender, HM Dasenbrock, J Schinkel, AH
Citation: Jw. Jonker et al., Role of blood-brain barrier P-glycoprotein in limiting brain accumulation and sedative side-effects of asimadoline, a peripherally acting analgaesic drug, BR J PHARM, 127(1), 1999, pp. 43-50
Increased accumulation of doxorubicin and doxorubicinol in cardiac tissue of mice lacking mdr1a P-glycoprotein
Authors: van Asperen, J van Tellingen, O Tijssen, F Schinkel, AH Beijnen, JH
Citation: J. Van Asperen et al., Increased accumulation of doxorubicin and doxorubicinol in cardiac tissue of mice lacking mdr1a P-glycoprotein, BR J CANC, 79(1), 1999, pp. 108-113
Risultati: 1-19 |