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Results: 1-25 | 26-37
Results: 1-25/37
Signal transduction pathways of IL-1 beta-mediated iNOS in pulmonary vascular smooth muscle cells
Authors: Finder, JD Petrus, JL Hamilton, A Villavicencio, RT Pitt, BR Sebti, SM
Citation: Jd. Finder et al., Signal transduction pathways of IL-1 beta-mediated iNOS in pulmonary vascular smooth muscle cells, AM J P-LUNG, 281(4), 2001, pp. L816-L823
Peptidomimetic inhibitors of protein farnesyltransferase show potent antimalarial activity
Authors: Ohkanda, J Lockman, JW Yokoyama, K Gelb, MH Croft, SL Kendrick, H Harrell, MI Feagin, JE Blaskovich, MA Sebti, SM Hamilton, AD
Citation: J. Ohkanda et al., Peptidomimetic inhibitors of protein farnesyltransferase show potent antimalarial activity, BIOORG MED, 11(6), 2001, pp. 761-764
Ras and RhoA suppress whereas RhoB enhances cytokine-induced transcriptionof nitric oxide synthase-2 in human normal liver AKN-1 cells and lung cancer A-549 cells
Authors: Delarue, FL Taylor, BS Sebti, SM
Citation: Fl. Delarue et al., Ras and RhoA suppress whereas RhoB enhances cytokine-induced transcriptionof nitric oxide synthase-2 in human normal liver AKN-1 cells and lung cancer A-549 cells, ONCOGENE, 20(45), 2001, pp. 6531-6537
The farnesyltransferase inhibitor, FTI-2153, blocks bipolar spindle formation and chromosome alignment and causes prometaphase accumulation during mitosis of human lung cancer cells
Authors: Crespo, NC Ohkanda, J Yen, TJ Hamilton, AD Sebti, SM
Citation: Nc. Crespo et al., The farnesyltransferase inhibitor, FTI-2153, blocks bipolar spindle formation and chromosome alignment and causes prometaphase accumulation during mitosis of human lung cancer cells, J BIOL CHEM, 276(19), 2001, pp. 16161-16167
CEP1612, a dipeptidyl proteasome inhibitor, induces p21(WAF1) and p27(KIP1) expression and apoptosis and inhibits the growth of the human lung adenocarcinoma A-549 in nude mice
Authors: Sun, JZ Nam, SK Lee, CS Li, BY Coppola, D Hamilton, AD Dou, QP Sebti, SM
Citation: Jz. Sun et al., CEP1612, a dipeptidyl proteasome inhibitor, induces p21(WAF1) and p27(KIP1) expression and apoptosis and inhibits the growth of the human lung adenocarcinoma A-549 in nude mice, CANCER RES, 61(4), 2001, pp. 1280-1284
Signaling events required for transforming growth factor-beta stimulation of connective tissue growth factor expression by cultured human lung fibroblasts
Authors: Kucich, U Rosenbloom, JC Herrick, DJ Abrams, WR Hamilton, AD Sebti, SM Rosenbloom, J
Citation: U. Kucich et al., Signaling events required for transforming growth factor-beta stimulation of connective tissue growth factor expression by cultured human lung fibroblasts, ARCH BIOCH, 395(1), 2001, pp. 103-112
Peptidomimetic-based inhibitors of farnesyltransferase
Authors: Knowles, D Sun, JZ Rosenberg, S Sebti, SM Hamilton, AD
Citation: D. Knowles et al., Peptidomimetic-based inhibitors of farnesyltransferase, CANC DRUG, 8, 2001, pp. 49-64
Prenyltransferase inhibitors as radiosensitizers
Authors: Bernhard, EJ Muschel, RH Cohen-Jonathan, E Favre, G Hamilton, AD Sebti, SM McKenna, WG
Citation: Ej. Bernhard et al., Prenyltransferase inhibitors as radiosensitizers, CANC DRUG, 8, 2001, pp. 171-195
Farnesyltransferase and geranylgeranyltransferase I inhibitors as novel agents for cancer and cardiovascular diseases
Authors: Sebti, SM Hamilton, AD
Citation: Sm. Sebti et Ad. Hamilton, Farnesyltransferase and geranylgeranyltransferase I inhibitors as novel agents for cancer and cardiovascular diseases, CANC DRUG, 8, 2001, pp. 197-219
Protein prenylation in trypanosomatids - A new piggy-back medicinal chemistry target for the development of agents against tropical diseases
Authors: Gelb, MH Buckner, FS Yokoyama, K Ohkanda, J Hamilton, AD Nguyen, L Rossi-Bergmann, B Stuart, KD Sebti, SM Van Voorhis, WC
Citation: Mh. Gelb et al., Protein prenylation in trypanosomatids - A new piggy-back medicinal chemistry target for the development of agents against tropical diseases, CANC DRUG, 8, 2001, pp. 221-232
Farnesyltransferase and geranylgeranyltransferase I inhibitors in cancer therapy: important mechanistic and bench to bedside issues
Authors: Sebti, SM Hamilton, AD
Citation: Sm. Sebti et Ad. Hamilton, Farnesyltransferase and geranylgeranyltransferase I inhibitors in cancer therapy: important mechanistic and bench to bedside issues, EXPERT OP I, 9(12), 2000, pp. 2767-2782
Design of GFB-111, a platelet-derived growth factor binding molecule with antiangiogenic and anticancer activity against human tumors in mice
Authors: Blaskovich, MA Lin, Q Delarue, FL Sun, J Park, HS Coppola, D Hamilton, AD Sebti, SM
Citation: Ma. Blaskovich et al., Design of GFB-111, a platelet-derived growth factor binding molecule with antiangiogenic and anticancer activity against human tumors in mice, NAT BIOTECH, 18(10), 2000, pp. 1065-1070
Colony-stimulating factor-1 receptor utilizes multiple signaling pathways to induce cyclin D2 expression
Authors: Dey, A She, HY Kim, L Boruch, A Guris, DL Carlberg, K Sebti, SM Woodley, DT Imamoto, A Li, W
Citation: A. Dey et al., Colony-stimulating factor-1 receptor utilizes multiple signaling pathways to induce cyclin D2 expression, MOL BIOL CE, 11(11), 2000, pp. 3835-3848
Prenyltransferase inhibitors block superoxide production by pulmonary vascular smooth muscle
Authors: Boota, A Johnson, B Lee, KL Blaskovich, MA Liu, SX Kagan, VE Hamilton, A Pitt, B Sebti, SM Davies, P
Citation: A. Boota et al., Prenyltransferase inhibitors block superoxide production by pulmonary vascular smooth muscle, AM J P-LUNG, 278(2), 2000, pp. L329-L334
Design of growth factor antagonists with antiangiogenic and antitumor properties
Authors: Sebti, SM Hamilton, AD
Citation: Sm. Sebti et Ad. Hamilton, Design of growth factor antagonists with antiangiogenic and antitumor properties, ONCOGENE, 19(56), 2000, pp. 6566-6573
Farnesyltransferase and geranylgeranyltransferase I inhibitors and cancer therapy: Lessons from mechanism and bench-to-bedside translational studies
Authors: Sebti, SM Hamilton, AD
Citation: Sm. Sebti et Ad. Hamilton, Farnesyltransferase and geranylgeranyltransferase I inhibitors and cancer therapy: Lessons from mechanism and bench-to-bedside translational studies, ONCOGENE, 19(56), 2000, pp. 6584-6593
Inhibition of farnesyltransferase increases TGF beta type II receptor expression and enhances the responsiveness of human cancer cells to TGF beta
Authors: Adnane, J Bizouarn, FA Chen, Z Ohkanda, J Hamilton, AD Munoz-Antonia, T Sebti, SM
Citation: J. Adnane et al., Inhibition of farnesyltransferase increases TGF beta type II receptor expression and enhances the responsiveness of human cancer cells to TGF beta, ONCOGENE, 19(48), 2000, pp. 5525-5533
Loss of p21(WAF1/CIP1) accelerates Ras oncogenesis in a transgenic/knockout mammary cancer model
Authors: Adnane, J Jackson, RJ Nicosia, SV Cantor, AB Pledger, WJ Sebti, SM
Citation: J. Adnane et al., Loss of p21(WAF1/CIP1) accelerates Ras oncogenesis in a transgenic/knockout mammary cancer model, ONCOGENE, 19(47), 2000, pp. 5338-5347
Tyrosine phosphorylation of focal adhesion kinase by PDGF is dependent on Ras in human hepatic stellate cells
Authors: Carloni, V Pinzani, M Giusti, S Romanelli, RG Parola, M Bellomo, G Failli, P Hamilton, AD Sebti, SM Laffi, G Gentilini, P
Citation: V. Carloni et al., Tyrosine phosphorylation of focal adhesion kinase by PDGF is dependent on Ras in human hepatic stellate cells, HEPATOLOGY, 31(1), 2000, pp. 131-140
The phosphoinositide 3-OH kinase/AKT2 pathway as a critical target for farnesyltransferase inhibitor-induced apoptosis
Authors: Jiang, K Coppola, D Crespo, NC Nicosia, SV Hamilton, AD Sebti, SM Cheng, JQ
Citation: K. Jiang et al., The phosphoinositide 3-OH kinase/AKT2 pathway as a critical target for farnesyltransferase inhibitor-induced apoptosis, MOL CELL B, 20(1), 2000, pp. 139-148
Effect of farnesyltransferase inhibitor FTI-276 on established lung adenomas from A/J mice induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone
Authors: Lantry, LE Zhang, ZQ Yao, RS Crist, KA Wang, Y Ohkanda, J Hamilton, AD Sebti, SM Lubet, RA You, M
Citation: Le. Lantry et al., Effect of farnesyltransferase inhibitor FTI-276 on established lung adenomas from A/J mice induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, CARCINOGENE, 21(1), 2000, pp. 113-116
Inhibition of Rho GTPases using protein geranylgeranyltransferase I inhibitors
Authors: Sebti, SM Hamilton, AD
Citation: Sm. Sebti et Ad. Hamilton, Inhibition of Rho GTPases using protein geranylgeranyltransferase I inhibitors, METH ENZYM, 325, 2000, pp. 381-388
Development of a tripeptide mimetic strategy for the inhibition of proteinfarnesyltransferase
Authors: Kothare, MA Ohkanda, J Lockman, JW Qian, YM Blaskovich, MA Sebti, SM Hamilton, AD
Citation: Ma. Kothare et al., Development of a tripeptide mimetic strategy for the inhibition of proteinfarnesyltransferase, TETRAHEDRON, 56(50), 2000, pp. 9833-9841
Farnesyltransferase inhibitors potentiate the antitumor effect of radiation on a human tumor xenograft expressing activated HRAS
Authors: Cohen-Jonathan, E Muschel, RJ McKenna, WG Evans, SM Cerniglia, G Mick, R Kusewitt, D Sebti, SM Hamilton, AD Oliff, A Kohl, N Gibbs, JB Bernhard, EJ
Citation: E. Cohen-jonathan et al., Farnesyltransferase inhibitors potentiate the antitumor effect of radiation on a human tumor xenograft expressing activated HRAS, RADIAT RES, 154(2), 2000, pp. 125-132
RhoA prenylation is required for promotion of cell growth and transformation and cytoskeleton organization but not for induction of serum response element transcription
Authors: Allal, C Favre, G Couderc, B Salicio, S Sixou, S Hamilton, AD Sebti, SM Lajoie-Mazenc, I Pradines, A
Citation: C. Allal et al., RhoA prenylation is required for promotion of cell growth and transformation and cytoskeleton organization but not for induction of serum response element transcription, J BIOL CHEM, 275(40), 2000, pp. 31001-31008
Risultati: 1-25 | 26-37