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Results: 1-17 |
Results: 17
NONPEPTIDIC HIV PROTEASE INHIBITORS - C-2-SYMMETRY-BASED DESIGN OF BIS-SULFONAMIDE DIHYDROPYRONES
Authors: JANAKIRAMAN MN WATENPAUGH KD TOMICH PK CHONG KT TURNER SR TOMMASI RA THAISRIVONGS S STROHBACH JW
Citation: Mn. Janakiraman et al., NONPEPTIDIC HIV PROTEASE INHIBITORS - C-2-SYMMETRY-BASED DESIGN OF BIS-SULFONAMIDE DIHYDROPYRONES, Bioorganic & medicinal chemistry letters, 8(10), 1998, pp. 1237-1242
TIPRANAVIR (PNU-140690) - A POTENT, ORALLY BIOAVAILABLE NONPEPTIDIC HIV PROTEASE INHIBITOR OF THE 5,6-DIHYDRO-4-HYDROXY-2-PYRONE SULFONAMIDE CLASS
Authors: TURNER SR STROHBACH JW TOMMASI RA ARISTOFF PA JOHNSON PD SKULNICK HI DOLAK LA SEEST EP TOMICH PK BOHANAN MJ HORNG MM LYNN JC CHONG KT HINSHAW RR WATENPAUGH KD JANAKIRAMAN MN THAISRIVONGS S
Citation: Sr. Turner et al., TIPRANAVIR (PNU-140690) - A POTENT, ORALLY BIOAVAILABLE NONPEPTIDIC HIV PROTEASE INHIBITOR OF THE 5,6-DIHYDRO-4-HYDROXY-2-PYRONE SULFONAMIDE CLASS, Journal of medicinal chemistry, 41(18), 1998, pp. 3467-3476
SYNTHESIS AND PHARMACOLOGICAL EVALUATION OF SULFONE SUBSTITUTED HIV PROTEASE INHIBITORS
Authors: SCHWARTZ TM BUNDY GL STROHBACH JW THAISRIVONGS S JOHNSON PD SKULNICK HI TOMICH PK LYNN JC CHONG KT HINSHAW RR RAUB TJ PADBURY GE TOTH LN
Citation: Tm. Schwartz et al., SYNTHESIS AND PHARMACOLOGICAL EVALUATION OF SULFONE SUBSTITUTED HIV PROTEASE INHIBITORS, Bioorganic & medicinal chemistry letters, 7(4), 1997, pp. 399-402
ANTIVIRAL ACTIVITY OF THE DIHYDROPYRONE PNU-140690, A NEW NONPEPTIDICHUMAN-IMMUNODEFICIENCY-VIRUS PROTEASE INHIBITOR
Authors: POPPE SM SLADE DE CHONG KT HINSHAW RR PAGANO PJ MARKOWITZ M HO DD MO H GORMAN RR DUEWEKE TJ THAISRIVONGS S TARPLEY WG
Citation: Sm. Poppe et al., ANTIVIRAL ACTIVITY OF THE DIHYDROPYRONE PNU-140690, A NEW NONPEPTIDICHUMAN-IMMUNODEFICIENCY-VIRUS PROTEASE INHIBITOR, Antimicrobial agents and chemotherapy, 41(5), 1997, pp. 1058-1063
POTENTIAL HIV PROTEASE INHIBITORS - PREPARATION OF DI-N-ALKYLATED 2-AMINODEOXY-DERIVATIVE, 6-AMINODEOXY-DERIVATIVE, AND 2,6-AMINODEOXY-DERIVATIVE OF D-GLUCOSE BY DIRECT DISPLACEMENT AND BY A NOVEL REDUCTIVE-ALKYLATION PROCEDURE
Authors: CAI JQ DAVISON BE GANELLIN CR THAISRIVONGS S WIBLEY KS
Citation: Jq. Cai et al., POTENTIAL HIV PROTEASE INHIBITORS - PREPARATION OF DI-N-ALKYLATED 2-AMINODEOXY-DERIVATIVE, 6-AMINODEOXY-DERIVATIVE, AND 2,6-AMINODEOXY-DERIVATIVE OF D-GLUCOSE BY DIRECT DISPLACEMENT AND BY A NOVEL REDUCTIVE-ALKYLATION PROCEDURE, Carbohydrate research, 300(2), 1997, pp. 109-117
STRUCTURE-BASED DESIGN OF HIV PROTEASE INHIBITORS - 5,6-DIHYDRO-4-HYDROXY-2-PYRONES AS EFFECTIVE, NONPEPTIDIC INHIBITORS
Authors: THAISRIVONGS S ROMERO DL TOMMASI RA JANAKIRAMAN MN STROHBACH JW TURNER SR BILES C MORGE RR JOHNSON PD ARISTOFF PA TOMICH PK LYNN JC HORNG MM CHONG KT HINSHAW RR HOWE WJ FINZEL BC WATENPAUGH KD
Citation: S. Thaisrivongs et al., STRUCTURE-BASED DESIGN OF HIV PROTEASE INHIBITORS - 5,6-DIHYDRO-4-HYDROXY-2-PYRONES AS EFFECTIVE, NONPEPTIDIC INHIBITORS, Journal of medicinal chemistry, 39(23), 1996, pp. 4630-4642
STRUCTURE-BASED DESIGN OF HIV PROTEASE INHIBITORS - SULFONAMIDE-CONTAINING 5,6-DIHYDRO-4-HYDROXY-2-PYRONES AS NONPEPTIDIC INHIBITORS
Authors: THAISRIVONGS S SKULNICK HI TURNER SR STROHBACH JW TOMMASI RA JOHNSON PD ARISTOFF PA JUDGE TM GAMMILL RB MORRIS JK ROMINES KR CHRUSCIEL RA HINSHAW RR CHONG KT TARPLEY WG POPPE SM SLADE DE LYNN JC HORNG MM TOMICH PK SEEST EP DOLAK LA HOWE WJ HOWARD GM SCHWENDE FJ TOTH LN PADBURY GE WILSON GJ SHIOU LH ZIPP GL WILKINSON KF RUSH BD RUWART MJ KOEPLINGER KA ZHAO ZY COLE S ZAYA RM KAKUK TJ JANAKIRAMAN MN WATENPAUGH KD
Citation: S. Thaisrivongs et al., STRUCTURE-BASED DESIGN OF HIV PROTEASE INHIBITORS - SULFONAMIDE-CONTAINING 5,6-DIHYDRO-4-HYDROXY-2-PYRONES AS NONPEPTIDIC INHIBITORS, Journal of medicinal chemistry, 39(22), 1996, pp. 4349-4353
NEW 3,4-O-ISOPROPYLIDENE DERIVATIVES OF D-GLUCOPYRANOSIDES AND L-GLUCOPYRANOSIDES
Authors: CAI JQ DAVISON BE GANELLIN CR THAISRIVONGS S
Citation: Jq. Cai et al., NEW 3,4-O-ISOPROPYLIDENE DERIVATIVES OF D-GLUCOPYRANOSIDES AND L-GLUCOPYRANOSIDES, Tetrahedron letters, 36(36), 1995, pp. 6535-6536
STRUCTURE-BASED DESIGN OF SULFONAMIDE-SUBSTITUTED NONPEPTIDIC HIV PROTEASE INHIBITORS
Authors: SKULNICK HI JOHNSON PD HOWE WJ TOMICH PK CHONG KT WATENPAUGH KD JANAKIRAMAN MN DOLAK LA MCGRATH JP LYNN JC HORNG MM HINSHAW RR ZIPP GL RUWART MJ SCHWENDE FJ ZHONG WZ PADBURY GE DALGA RJ SHIOU LH POSSERT PL RUSH BD WILKINSON KF HOWARD GM TOTH LN WILLIAMS MG KAKUK TJ COLE SL ZAYA RM LOVASZ KD MORRIS JK ROMINES KR THAISRIVONGS S ARISTOFF PA
Citation: Hi. Skulnick et al., STRUCTURE-BASED DESIGN OF SULFONAMIDE-SUBSTITUTED NONPEPTIDIC HIV PROTEASE INHIBITORS, Journal of medicinal chemistry, 38(26), 1995, pp. 4968-4971
STRUCTURE-BASED DESIGN OF NOVEL HIV PROTEASE INHIBITORS - CARBOXAMIDE-CONTAINING 4-HYDROXYCOUMARINS AND 4-HYDROXY-2-PYRONES AS POTENT NONPEPTIDIC INHIBITORS
Authors: THAISRIVONGS S WATENPAUGH KD HOWE WJ TOMICH PK DOLAK LA CHONG KT TOMICH CSC TOMASSELLI AG TURNER SR STROHBACH JW MULICHAK AM JANAKIRAMAN MN MOON JB LYNN JC HORNG MM HINSHAW RR CURRY KA ROTHROCK DJ
Citation: S. Thaisrivongs et al., STRUCTURE-BASED DESIGN OF NOVEL HIV PROTEASE INHIBITORS - CARBOXAMIDE-CONTAINING 4-HYDROXYCOUMARINS AND 4-HYDROXY-2-PYRONES AS POTENT NONPEPTIDIC INHIBITORS, Journal of medicinal chemistry, 38(18), 1995, pp. 3624-3637
EFFECT OF POINT MUTATIONS ON THE KINETICS AND THE INHIBITION OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 PROTEASE - RELATIONSHIP TO DRUG-RESISTANCE
Authors: LIN YZ LIN XL HONG L FOUNDLING S HEINRIKSON RL THAISRIVONGS S LEELAMANIT W RATERMAN D SHAH M DUNN BM TANG J
Citation: Yz. Lin et al., EFFECT OF POINT MUTATIONS ON THE KINETICS AND THE INHIBITION OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 PROTEASE - RELATIONSHIP TO DRUG-RESISTANCE, Biochemistry, 34(4), 1995, pp. 1143-1152
EFFECTS OF U-75875, A PEPTIDOMIMETIC INHIBITOR OF RETROVIRAL PROTEASES, ON SIMIAN IMMUNODEFICIENCY VIRUS-INFECTION IN RHESUS-MONKEYS
Authors: MARTIN LN SOIKE KF MURPHEYCORB M BOHM RP ROBERTS ED KAKUK TJ THAISRIVONGS S VIDMAR TJ RUWART MJ DAVIO SR TARPLEY WG
Citation: Ln. Martin et al., EFFECTS OF U-75875, A PEPTIDOMIMETIC INHIBITOR OF RETROVIRAL PROTEASES, ON SIMIAN IMMUNODEFICIENCY VIRUS-INFECTION IN RHESUS-MONKEYS, Antimicrobial agents and chemotherapy, 38(6), 1994, pp. 1277-1283
STRUCTURE-BASED DESIGN OF HIV PROTEASE INHIBITORS - 4-HYDROXYCOUMARINS AND 4-HYDROXY-2-PYRONES AS NONPEPTIDIC INHIBITORS
Authors: THAISRIVONGS S TOMICH PK WATENPAUGH KD CHONG KT HOWE WJ YANG CP STROHBACH JW TURNER SR MCGRATH JP BOHANON MJ LYNN JC MULICHAK AM SPINELLI PA HINSHAW RR PAGANO PJ MOON JB RUWART MJ WILKINSON KF RUSH BD ZIPP GL DALGA RJ SCHWENDE FJ HOWARD GM PADBURY GE TOTH LN ZHAO ZY KOEPLINGER KA KAKUK TJ COLE SL ZAYA RM PIPER RC JEFFREY P
Citation: S. Thaisrivongs et al., STRUCTURE-BASED DESIGN OF HIV PROTEASE INHIBITORS - 4-HYDROXYCOUMARINS AND 4-HYDROXY-2-PYRONES AS NONPEPTIDIC INHIBITORS, Journal of medicinal chemistry, 37(20), 1994, pp. 3200-3204
INHIBITORS OF THE PROTEASE FROM HUMAN-IMMUNODEFICIENCY-VIRUS - SYNTHESIS, ENZYME-INHIBITION, AND ANTIVIRAL ACTIVITY OF A SERIES OF COMPOUNDS CONTAINING THE DIHYDROXYETHYLENE TRANSITION-STATE ISOSTERE
Authors: THAISRIVONGS S TURNER SR STROHBACH JW TENBRINK RE TARPLEY WG MCQUADE TJ HEINRIKSON RL TOMASSELLI AG HUI JO HOWE WJ
Citation: S. Thaisrivongs et al., INHIBITORS OF THE PROTEASE FROM HUMAN-IMMUNODEFICIENCY-VIRUS - SYNTHESIS, ENZYME-INHIBITION, AND ANTIVIRAL ACTIVITY OF A SERIES OF COMPOUNDS CONTAINING THE DIHYDROXYETHYLENE TRANSITION-STATE ISOSTERE, Journal of medicinal chemistry, 36(8), 1993, pp. 941-952
PEPTIDOMIMETIC HIV PROTEASE INHIBITORS - PHOSPHATE PRODRUGS WITH IMPROVED BIOLOGICAL-ACTIVITIES
Authors: CHONG KT RUWART MJ HINSHAW RR WILKINSON KF RUSH BD YANCEY MF STROHBACH JW THAISRIVONGS S
Citation: Kt. Chong et al., PEPTIDOMIMETIC HIV PROTEASE INHIBITORS - PHOSPHATE PRODRUGS WITH IMPROVED BIOLOGICAL-ACTIVITIES, Journal of medicinal chemistry, 36(17), 1993, pp. 2575-2577
INHIBITION OF THE PROTEASE OF HUMAN-IMMUNODEFICIENCY-VIRUS BLOCKS REPLICATION AND INFECTIVITY OF THE VIRUS IN CHRONICALLY INFECTED MACROPHAGES
Authors: PERNO CF BERGAMINI A PESCE CD MILANESE G CAPOZZI M AQUARO S THAISRIVONGS S TARPLEY WG ZON G DAGOSTINI C ROCCHI G GARACI E CALIO R
Citation: Cf. Perno et al., INHIBITION OF THE PROTEASE OF HUMAN-IMMUNODEFICIENCY-VIRUS BLOCKS REPLICATION AND INFECTIVITY OF THE VIRUS IN CHRONICALLY INFECTED MACROPHAGES, The Journal of infectious diseases, 168(5), 1993, pp. 1148-1156
THE CRYSTALLOGRAPHIC STRUCTURE OF THE PROTEASE FROM HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-2 WITH 2 SYNTHETIC PEPTIDIC TRANSITION-STATE ANALOG INHIBITORS
Authors: MULICHAK AM HUI JO TOMASSELLI AG HEINRIKSON RL CURRY KA TOMICH CS THAISRIVONGS S SAWYER TK WATENPAUGH KD
Citation: Am. Mulichak et al., THE CRYSTALLOGRAPHIC STRUCTURE OF THE PROTEASE FROM HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-2 WITH 2 SYNTHETIC PEPTIDIC TRANSITION-STATE ANALOG INHIBITORS, The Journal of biological chemistry, 268(18), 1993, pp. 3103-3109
Risultati: 1-17 |