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Antinociceptive activity of derivatives of improgran and burimamide
Authors: Hough, LB Nalwalk, JW Leurs, R Menge, WMPB Timmerman, H
Citation: Lb. Hough et al., Antinociceptive activity of derivatives of improgran and burimamide, PHARM BIO B, 65(1), 2000, pp. 61-66
Characterization of histamine H-3 receptors in mouse brain using the H-3 antagonist [I-125]iodophenpropit
Authors: Jansen, FP Mochizuki, T Maeyama, K Leurs, R Timmerman, H
Citation: Fp. Jansen et al., Characterization of histamine H-3 receptors in mouse brain using the H-3 antagonist [I-125]iodophenpropit, N-S ARCH PH, 362(1), 2000, pp. 60-67
The effect of mutations in the DRY motif on the constitutive activity and structural instability of the histamine H-2 receptor
Authors: Alewijnse, AE Timmerman, H Jacobs, EH Smit, MJ Roovers, E Cotecchia, S Leurs, R
Citation: Ae. Alewijnse et al., The effect of mutations in the DRY motif on the constitutive activity and structural instability of the histamine H-2 receptor, MOLEC PHARM, 57(5), 2000, pp. 890-898
The ligand-receptor-G-protein ternary complex as a GTP-synthase. Steady-state proton pumping and dose-response relationships for beta-adrenoceptors
Authors: Broadley, KJ Nederkoorn, PHJ Timmerman, H Timms, D Davies, RH
Citation: Kj. Broadley et al., The ligand-receptor-G-protein ternary complex as a GTP-synthase. Steady-state proton pumping and dose-response relationships for beta-adrenoceptors, J THEOR BIO, 205(2), 2000, pp. 297-320
Characterization of the binding site of the histamine H-3 receptor. 2. Synthesis, in vitro pharmacology, and QSAR of a series of monosubstituted benzyl analogues of thioperamide
Authors: Windhorst, AD Timmerman, H Worthington, EA Bijloo, GJ Nederkoorn, PHJ Menge, WMPB Leurs, R Herscheid, JDM
Citation: Ad. Windhorst et al., Characterization of the binding site of the histamine H-3 receptor. 2. Synthesis, in vitro pharmacology, and QSAR of a series of monosubstituted benzyl analogues of thioperamide, J MED CHEM, 43(9), 2000, pp. 1754-1761
Isoquinoline and quinazoline urea analogues as antagonists for the human adenosine A(3) receptor
Authors: van Muijlwijk-Koezen, JE Timmerman, H van der Goot, H Menge, WMPB Kunzel, JFV de Groote, M IJzerman, AP
Citation: Je. Van Muijlwijk-koezen et al., Isoquinoline and quinazoline urea analogues as antagonists for the human adenosine A(3) receptor, J MED CHEM, 43(11), 2000, pp. 2227-2238
Histamine H-1 receptor ligands Part II. Synthesis and in vitro pharmacology of 2-[2-(phenylamino)thiazol-4-yl]ethanamine and 2-(2-benzhydrylthiazol-4-yl)ethanamine derivatives
Authors: Walczynski, K Guryn, R Zuiderveld, OP Zhang, MQ Timmerman, H
Citation: K. Walczynski et al., Histamine H-1 receptor ligands Part II. Synthesis and in vitro pharmacology of 2-[2-(phenylamino)thiazol-4-yl]ethanamine and 2-(2-benzhydrylthiazol-4-yl)ethanamine derivatives, FARMACO, 55(9-10), 2000, pp. 569-574
Constitutive activity of the histamine H-1 receptor reveals inverse agonism of histamine H-1 receptor antagonists
Authors: Bakker, RA Wieland, K Timmerman, H Leurs, R
Citation: Ra. Bakker et al., Constitutive activity of the histamine H-1 receptor reveals inverse agonism of histamine H-1 receptor antagonists, EUR J PHARM, 387(1), 2000, pp. R5-R7
Modulation of histamine H-2 receptor signalling by G-protein-coupled receptor kinase 2 and 3
Authors: Rodriguez-Pena, MS Timmerman, H Leurs, R
Citation: Ms. Rodriguez-pena et al., Modulation of histamine H-2 receptor signalling by G-protein-coupled receptor kinase 2 and 3, BR J PHARM, 131(8), 2000, pp. 1707-1715
Improgan, a cimetidine analog, induces morphine-like antinociception in opioid receptor-knockout mice
Authors: Hough, LB Nalwalk, JW Chen, Y Schuller, A Zhu, Y Zhang, J Menge, WMPB Leurs, R Timmerman, H Pintar, JE
Citation: Lb. Hough et al., Improgan, a cimetidine analog, induces morphine-like antinociception in opioid receptor-knockout mice, BRAIN RES, 880(1-2), 2000, pp. 102-108
Radiosynthesis and biodistribution of I-123-labeled antagonists of the histamine H-3 receptor as potential SPECT ligands
Authors: Windhorst, AD Timmerman, H Klok, RP Custers, FGJ Menge, WMPB Leurs, R Stark, H Schunack, W Gielen, EGJ van Kroonenburgh, MJPG Herscheid, JDM
Citation: Ad. Windhorst et al., Radiosynthesis and biodistribution of I-123-labeled antagonists of the histamine H-3 receptor as potential SPECT ligands, NUCL MED BI, 26(6), 1999, pp. 651-659
Evaluation of [F-18]VUF 5000 as a potential PET ligand for brain imaging of the histamine H-3 receptor
Authors: Windhorst, AD Timmerman, H Klok, RP Menge, WMPB Leurs, R Herscheid, JDM
Citation: Ad. Windhorst et al., Evaluation of [F-18]VUF 5000 as a potential PET ligand for brain imaging of the histamine H-3 receptor, BIO MED CH, 7(9), 1999, pp. 1761-1767
Synthesis and histamine H-3 receptor activity of 4-(n-alkyl)-1H-imidazolesand 4-(omega-phenylalkyl)-1H-imidazoles
Authors: De Esch, IJP Gaffar, A Menge, WMPB Timmerman, H
Citation: Ijp. De Esch et al., Synthesis and histamine H-3 receptor activity of 4-(n-alkyl)-1H-imidazolesand 4-(omega-phenylalkyl)-1H-imidazoles, BIO MED CH, 7(12), 1999, pp. 3003-3009
Why are non-sedating antihistamines non-sedating?
Authors: Timmerman, H
Citation: H. Timmerman, Why are non-sedating antihistamines non-sedating?, CLIN EXP AL, 29, 1999, pp. 13-18
Molecular properties and signalling pathways of the histamine H-1 receptor
Authors: Smit, MJ Hoffmann, M Timmerman, H Leurs, R
Citation: Mj. Smit et al., Molecular properties and signalling pathways of the histamine H-1 receptor, CLIN EXP AL, 29, 1999, pp. 19-28
Non-imidazole histamine H-3 ligands, part 2: New 2-substituted benzothiazoles as histamine H-3 antagonists
Authors: Walczynski, K Guryn, R Zuiderveld, OP Timmerman, H
Citation: K. Walczynski et al., Non-imidazole histamine H-3 ligands, part 2: New 2-substituted benzothiazoles as histamine H-3 antagonists, ARCH PHARM, 332(11), 1999, pp. 389-398
Synthesis, in vitro pharmacology and radiosynthesis of N-(cis-4-fluoromethylcyclohexyl)-4-(1(H)-imidazol-4-yl)piperidine-1-thiocarbonamide (VUF 5000), a potential pet ligand for the histamine H-3 receptor.
Authors: Windhorst, AD Timmerman, H Menge, WMPB Leurs, R Herscheid, JDM
Citation: Ad. Windhorst et al., Synthesis, in vitro pharmacology and radiosynthesis of N-(cis-4-fluoromethylcyclohexyl)-4-(1(H)-imidazol-4-yl)piperidine-1-thiocarbonamide (VUF 5000), a potential pet ligand for the histamine H-3 receptor., J LABEL C R, 42(3), 1999, pp. 293-307
Characterization of the binding site of the histamine H-3 receptor. 1. Various approaches to the synthesis of 2-(1H-imidazol-4-yl)cyclopropylamine and histaminergic activity of (1R,2R)- and (1S,2S)-2-(1H-imidazol-4-yl)cyclopropylamine
Authors: De Esch, IJP Vollinga, RC Goubitz, K Schenk, H Appelberg, U Hacksell, U Lemstra, S Zuiderveld, OP Hoffmann, M Leurs, R Menge, WMPB Timmerman, H
Citation: Ijp. De Esch et al., Characterization of the binding site of the histamine H-3 receptor. 1. Various approaches to the synthesis of 2-(1H-imidazol-4-yl)cyclopropylamine and histaminergic activity of (1R,2R)- and (1S,2S)-2-(1H-imidazol-4-yl)cyclopropylamine, J MED CHEM, 42(7), 1999, pp. 1115-1122
Mutational analysis of the antagonist-binding site of the histamine H-1 receptor
Authors: Wieland, K Ter Laak, AM Smit, MJ Kuhne, R Timmerman, H Leurs, R
Citation: K. Wieland et al., Mutational analysis of the antagonist-binding site of the histamine H-1 receptor, J BIOL CHEM, 274(42), 1999, pp. 29994-30000
Histamine H-1 receptor ligands Part I. Novel thiazol-4-ylethanamine derivatives: synthesis and in vitro pharmacology
Authors: Walczynski, K Timmerman, H Zuiderveld, OP Zhang, MQ Glinka, R
Citation: K. Walczynski et al., Histamine H-1 receptor ligands Part I. Novel thiazol-4-ylethanamine derivatives: synthesis and in vitro pharmacology, FARMACO, 54(8), 1999, pp. 533-541
Non-imidazole histamine H-3 ligands. Part I. Synthesis of 2-(1-piperazinyl)- and 2-(hexahydro-1H-1,4-diazepin-1-yl)benzothiazole derivatives as H-3-antagonists with H-1 blocking activities
Authors: Walczynski, K Guryn, R Zuiderweld, OP Timmerman, H
Citation: K. Walczynski et al., Non-imidazole histamine H-3 ligands. Part I. Synthesis of 2-(1-piperazinyl)- and 2-(hexahydro-1H-1,4-diazepin-1-yl)benzothiazole derivatives as H-3-antagonists with H-1 blocking activities, FARMACO, 54(10), 1999, pp. 684-694
Nitric oxide synthase inhibition by dimaprit and dimaprit analogues
Authors: Paquay, JBG 't Hoen, PAC Voss, HP Bast, A Timmerman, H Haenen, GRMM
Citation: Jbg. Paquay et al., Nitric oxide synthase inhibition by dimaprit and dimaprit analogues, BR J PHARM, 127(2), 1999, pp. 331-334
Agonist-independent regulation of constitutively active G-protein-coupled receptors
Authors: Leurs, R Smit, MJ Alewijnse, AE Timmerman, H
Citation: R. Leurs et al., Agonist-independent regulation of constitutively active G-protein-coupled receptors, TRENDS BIOC, 23(11), 1998, pp. 418-422
Radioligands for the histamine H-3 receptor and their use in pharmacology.
Authors: Jansen, FP Leurs, R Timmerman, H
Citation: Fp. Jansen et al., Radioligands for the histamine H-3 receptor and their use in pharmacology., PHARMCHEM L, 30, 1998, pp. 127-144
Substituted imidazoles, the key to histaminergic receptors
Authors: Menge, WMPB Timmerman, H
Citation: Wmpb. Menge et H. Timmerman, Substituted imidazoles, the key to histaminergic receptors, PHARMCHEM L, 30, 1998, pp. 145-158
Risultati: 1-25 | 26-50 | 51-55