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Results: 1-17 |
Results: 17
A multireceptorial binding reinvestigation on an extended class of sigma ligands: N-[omega-(Indan-1-yl and tetralin-1-yl)alkyl] derivatives of 3,3-dimethylpiperidine reveal high affinities towards sigma(1) and EBP sites
Authors: Berardi, F Ferorelli, S Colabufo, NA Leopoldo, M Perrone, R Tortorella, V
Citation: F. Berardi et al., A multireceptorial binding reinvestigation on an extended class of sigma ligands: N-[omega-(Indan-1-yl and tetralin-1-yl)alkyl] derivatives of 3,3-dimethylpiperidine reveal high affinities towards sigma(1) and EBP sites, BIO MED CH, 9(5), 2001, pp. 1325-1335
Trans-4-[4-(methoxyphenyl)cyclohexyll-1-arylpiperazines: A new class of potent and selective 5-HT1A receptor ligands as conformationally constrained analogues of 4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]-1-arylpiperazines
Authors: Perrone, R Berardi, F Colabufo, NA Leopoldo, M Lacivita, E Tortorella, V Leonardi, A Poggesi, E Testa, R
Citation: R. Perrone et al., Trans-4-[4-(methoxyphenyl)cyclohexyll-1-arylpiperazines: A new class of potent and selective 5-HT1A receptor ligands as conformationally constrained analogues of 4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]-1-arylpiperazines, J MED CHEM, 44(25), 2001, pp. 4431-4442
Determination of dopamine D-4 receptor density in rat striatum using PB12 as a probe
Authors: Colabufo, NA Berardi, F Calo, R Leopoldo, M Perrone, R Tortorella, V
Citation: Na. Colabufo et al., Determination of dopamine D-4 receptor density in rat striatum using PB12 as a probe, EUR J PHARM, 427(1), 2001, pp. 1-5
N-aryl- or N-alkylpiperazine derivatives: The role of N-substituent on sigma(1), sigma(2), 5-HT1A and D-2 receptor affinity
Authors: Perrone, R Berardi, F Colabufo, NA Leopoldo, M Abate, C Tortorella, V
Citation: R. Perrone et al., N-aryl- or N-alkylpiperazine derivatives: The role of N-substituent on sigma(1), sigma(2), 5-HT1A and D-2 receptor affinity, MED CHEM RE, 10(4), 2000, pp. 201-207
1-substituted-4-[3-(1,2,3,4-tetrahydro-5-or 7-methoxynaphthalen-1-yl)propyl]piperazines: Influence of the N-1 piperazine substituent on 5-HT1A receptor affinity and selectivity versus D-2 and alpha(1) receptors. Part 6
Authors: Perrone, R Berardi, F Colabufo, NA Leopoldo, M Tortorella, V
Citation: R. Perrone et al., 1-substituted-4-[3-(1,2,3,4-tetrahydro-5-or 7-methoxynaphthalen-1-yl)propyl]piperazines: Influence of the N-1 piperazine substituent on 5-HT1A receptor affinity and selectivity versus D-2 and alpha(1) receptors. Part 6, BIO MED CH, 8(5), 2000, pp. 873-881
Stereospecific synthesis of mexiletine and related compounds: Mitsunobu versus Williamson reaction
Authors: Carocci, A Catalano, A Corbo, F Duranti, A Amoroso, R Franchini, C Lentini, G Tortorella, V
Citation: A. Carocci et al., Stereospecific synthesis of mexiletine and related compounds: Mitsunobu versus Williamson reaction, TETRAHEDR-A, 11(17), 2000, pp. 3619-3634
Facile entry to (-)-(R)- and (+)-(S)-mexiletine
Authors: Carocci, A Franchini, C Lentini, G Loiodice, F Tortorella, V
Citation: A. Carocci et al., Facile entry to (-)-(R)- and (+)-(S)-mexiletine, CHIRALITY, 12(3), 2000, pp. 103-106
Different behavior toward racemization in basic media from chiral analogs of clofibric acid, the active metabolite of the antilipidemic drug clofibrate
Authors: Ferorelli, S Loiodice, F Longo, A Molfetta, A Tortorella, V Amoroso, R
Citation: S. Ferorelli et al., Different behavior toward racemization in basic media from chiral analogs of clofibric acid, the active metabolite of the antilipidemic drug clofibrate, CHIRALITY, 12(10), 2000, pp. 697-704
Homologation of mexiletine alkyl chain and stereoselective blockade of skeletal muscle sodium channels
Authors: Duranti, A Franchini, C Lentini, G Loiodice, F Tortorella, V De Luca, A Pierno, S Camerino, DC
Citation: A. Duranti et al., Homologation of mexiletine alkyl chain and stereoselective blockade of skeletal muscle sodium channels, EUR J MED C, 35(1), 2000, pp. 147-156
Pharmacological characterization of chloride channels belonging to the ClCfamily by the use of chiral clofibric acid derivatives
Authors: Pusch, M Liantonio, A Bertorello, L Accardi, A De Luca, A Pierno, S Tortorella, V Camerino, DC
Citation: M. Pusch et al., Pharmacological characterization of chloride channels belonging to the ClCfamily by the use of chiral clofibric acid derivatives, MOLEC PHARM, 58(3), 2000, pp. 498-507
Molecular determinants of mexiletine structure for potent and use-dependent block of skeletal muscle sodium channels
Authors: De Luca, A Natuzzi, F Desaphy, JF Loni, G Lentini, G Franchini, C Tortorella, V Camerino, DC
Citation: A. De Luca et al., Molecular determinants of mexiletine structure for potent and use-dependent block of skeletal muscle sodium channels, MOLEC PHARM, 57(2), 2000, pp. 268-277
Synthesis of new 2,6-prolylxylidide analogues of tocainide as stereoselective blockers of voltage-gated Na+ channels with increased potency and improved use-dependent activity
Authors: Franchini, C Corbo, F Lentini, G Bruno, G Scilimati, A Tortorella, V Camerino, DC De Luca, A
Citation: C. Franchini et al., Synthesis of new 2,6-prolylxylidide analogues of tocainide as stereoselective blockers of voltage-gated Na+ channels with increased potency and improved use-dependent activity, J MED CHEM, 43(20), 2000, pp. 3792-3798
A structure-affinity relationship study on derivatives of N-[2-[4-(4-chlorophenyl)piperazin-1-yl]ethyl]-3-methoxybenzamide, a high-affinity and selective D-4 receptor ligand
Authors: Perrone, R Berardi, F Colabufo, NA Leopoldo, M Tortorella, V
Citation: R. Perrone et al., A structure-affinity relationship study on derivatives of N-[2-[4-(4-chlorophenyl)piperazin-1-yl]ethyl]-3-methoxybenzamide, a high-affinity and selective D-4 receptor ligand, J MED CHEM, 43(2), 2000, pp. 270-277
2-(aryloxy)ethylamine derivatives: Ring opened congeners of long chain 1-arylpiperazines with high 5-HT1A receptor affinity and selectivity versus D-2 and alpha(1) receptors
Authors: Perrone, R Berardi, F Colabufo, NA Leopoldo, M Tortorella, V
Citation: R. Perrone et al., 2-(aryloxy)ethylamine derivatives: Ring opened congeners of long chain 1-arylpiperazines with high 5-HT1A receptor affinity and selectivity versus D-2 and alpha(1) receptors, MED CHEM RE, 9(5), 1999, pp. 340-353
Effect of mexiletine on sea anemone toxin-induced non-inactivating sodium channels of rat skeletal muscle: a model of sodium channel myotonia
Authors: Desaphy, JF Camerino, DC Tortorella, V De Luca, A
Citation: Jf. Desaphy et al., Effect of mexiletine on sea anemone toxin-induced non-inactivating sodium channels of rat skeletal muscle: a model of sodium channel myotonia, NEUROMUSC D, 9(3), 1999, pp. 182-189
1-aryl-4-[(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)alkyl]piperazines and their analogues: Influence of the stereochemistry of the tetrahydronaphthalen-1-yl nucleus on 5-HT1A receptor affinity and selectivity versus alpha(1) and D-2 receptors. 5
Authors: Perrone, R Berardi, F Colabufo, NA Leopoldo, M Tortorella, V
Citation: R. Perrone et al., 1-aryl-4-[(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)alkyl]piperazines and their analogues: Influence of the stereochemistry of the tetrahydronaphthalen-1-yl nucleus on 5-HT1A receptor affinity and selectivity versus alpha(1) and D-2 receptors. 5, J MED CHEM, 42(3), 1999, pp. 490-496
Increased hindrance on the chiral carbon atom of mexiletine enhances the block of rat skeletal muscle Na+ channels in a model of myotonia induced by ATX
Authors: Desaphy, JF Camerino, DC Franchini, C Lentini, G Tortorella, V De Luca, A
Citation: Jf. Desaphy et al., Increased hindrance on the chiral carbon atom of mexiletine enhances the block of rat skeletal muscle Na+ channels in a model of myotonia induced by ATX, BR J PHARM, 128(6), 1999, pp. 1165-1174
Risultati: 1-17 |