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Results: 1-22 |
Results: 22
Structure of beta-lactam synthetase reveals how to synthesize antibiotics instead of asparagine
Authors: Miller, MT Bachmann, BO Townsend, CA Rosenzweig, AC
Citation: Mt. Miller et al., Structure of beta-lactam synthetase reveals how to synthesize antibiotics instead of asparagine, NAT ST BIOL, 8(8), 2001, pp. 684-689
Hexanoate synthase, a specialized type I fatty acid synthase in aflatoxin B-1 biosynthesis
Authors: Hitchman, TS Schmidt, EW Trail, F Rarick, MD Linz, JE Townsend, CA
Citation: Ts. Hitchman et al., Hexanoate synthase, a specialized type I fatty acid synthase in aflatoxin B-1 biosynthesis, BIOORG CHEM, 29(5), 2001, pp. 293-307
Haemophilus ducreyi associates with phagocytes, collagen, and fibrin and remains extracellular throughout infection of human volunteers
Authors: Bauer, ME Goheen, MP Townsend, CA Spinola, SM
Citation: Me. Bauer et al., Haemophilus ducreyi associates with phagocytes, collagen, and fibrin and remains extracellular throughout infection of human volunteers, INFEC IMMUN, 69(4), 2001, pp. 2549-2557
Spectroscopic studies of substrate interactions with clavaminate synthase 2, a multifunctional alpha-KG-dependent non-heme iron enzyme: Correlation with mechanisms and reactivities
Authors: Zhou, J Kelly, WL Bachmann, BO Gunsior, M Townsend, CA Solomon, EI
Citation: J. Zhou et al., Spectroscopic studies of substrate interactions with clavaminate synthase 2, a multifunctional alpha-KG-dependent non-heme iron enzyme: Correlation with mechanisms and reactivities, J AM CHEM S, 123(30), 2001, pp. 7388-7398
Predictive, structure-based model of amino acid recognition by nonribosomal peptide synthetase adenylation domains
Authors: Challis, GL Ravel, J Townsend, CA
Citation: Gl. Challis et al., Predictive, structure-based model of amino acid recognition by nonribosomal peptide synthetase adenylation domains, CHEM BIOL, 7(3), 2000, pp. 211-224
Requirement of monooxygenase-mediated steps for sterigmatocystin biosynthesis by Aspergillus nidulans
Authors: Keller, NP Watanabe, CMH Kelkar, HS Adams, TH Townsend, CA
Citation: Np. Keller et al., Requirement of monooxygenase-mediated steps for sterigmatocystin biosynthesis by Aspergillus nidulans, APPL ENVIR, 66(1), 2000, pp. 359-362
Reduced food intake and body weight in mice treated with fatty acid synthase inhibitors
Authors: Loftus, TM Jaworsky, DE Frehywot, GL Townsend, CA Ronnett, GV Lane, MD Kuhajda, FP
Citation: Tm. Loftus et al., Reduced food intake and body weight in mice treated with fatty acid synthase inhibitors, SCIENCE, 288(5475), 2000, pp. 2379-2381
Synthesis and antitumor activity of an inhibitor of fatty acid synthase
Authors: Kuhajda, FP Pizer, ES Li, JN Mani, NS Frehywot, GL Townsend, CA
Citation: Fp. Kuhajda et al., Synthesis and antitumor activity of an inhibitor of fatty acid synthase, P NAS US, 97(7), 2000, pp. 3450-3454
A new class of antituberculosis agents
Authors: Jones, PB Parrish, NM Houston, TA Stapon, A Bansal, NP Dick, JD Townsend, CA
Citation: Pb. Jones et al., A new class of antituberculosis agents, J MED CHEM, 43(17), 2000, pp. 3304-3314
Expansion of the clavulanic acid gene cluster: Identification and in vivo functional analysis of three new genes required for biosynthesis of clavulanic acid by Streptomyces clavuligerus
Authors: Li, RF Khaleeli, N Townsend, CA
Citation: Rf. Li et al., Expansion of the clavulanic acid gene cluster: Identification and in vivo functional analysis of three new genes required for biosynthesis of clavulanic acid by Streptomyces clavuligerus, J BACT, 182(14), 2000, pp. 4087-4095
Malonyl-coenzyme-A is a potential mediator of cytotoxicity induced by fatty-acid synthase inhibition in human breast cancer cells and xenograft
Authors: Pizer, ES Thupari, J Han, WF Pinn, ML Chrest, FJ Frehywot, GL Townsend, CA Kuhajda, FP
Citation: Es. Pizer et al., Malonyl-coenzyme-A is a potential mediator of cytotoxicity induced by fatty-acid synthase inhibition in human breast cancer cells and xenograft, CANCER RES, 60(2), 2000, pp. 213-218
Kinetic mechanism of the beta-lactam synthetase of Streptomyces clavuligerus
Authors: Bachmann, BO Townsend, CA
Citation: Bo. Bachmann et Ca. Townsend, Kinetic mechanism of the beta-lactam synthetase of Streptomyces clavuligerus, BIOCHEM, 39(37), 2000, pp. 11187-11193
Site-directed mutagenesis and biochemical analysis of the endogenous ligands in the ferrous active site of clavaminate synthase. The His-3 variant ofthe 2-His-1-carboxylate model
Authors: Khaleeli, N Busby, RW Townsend, CA
Citation: N. Khaleeli et al., Site-directed mutagenesis and biochemical analysis of the endogenous ligands in the ferrous active site of clavaminate synthase. The His-3 variant ofthe 2-His-1-carboxylate model, BIOCHEM, 39(29), 2000, pp. 8666-8673
Calicheamicin-homeodomain conjugate as an efficient, sequence-specific DNAcleavage and mapping tool
Authors: Wu, MW Stoermer, D Tullius, TD Townsend, CA
Citation: Mw. Wu et al., Calicheamicin-homeodomain conjugate as an efficient, sequence-specific DNAcleavage and mapping tool, J AM CHEM S, 122(51), 2000, pp. 12884-12885
Three unusual reactions mediate carbapenem and carbapenam biosynthesis
Authors: Li, RF Stapon, A Blanchfield, JT Townsend, CA
Citation: Rf. Li et al., Three unusual reactions mediate carbapenem and carbapenam biosynthesis, J AM CHEM S, 122(38), 2000, pp. 9296-9297
Total synthesis of O-methylsterigmatocystin using N-alkylnitrilium salts and carbonyl-alkene interconversion in a new xanthone synthesis
Authors: Casillas, LK Townsend, CA
Citation: Lk. Casillas et Ca. Townsend, Total synthesis of O-methylsterigmatocystin using N-alkylnitrilium salts and carbonyl-alkene interconversion in a new xanthone synthesis, J ORG CHEM, 64(11), 1999, pp. 4050-4059
beta-secondary kinetic isotope effects in the clavaminate synthase-catalyzed oxidative cyclization of proclavaminic acid and in related azetidinone model reactions
Authors: Iwata-Reuyl, D Basak, A Townsend, CA
Citation: D. Iwata-reuyl et al., beta-secondary kinetic isotope effects in the clavaminate synthase-catalyzed oxidative cyclization of proclavaminic acid and in related azetidinone model reactions, J AM CHEM S, 121(49), 1999, pp. 11356-11368
Origin of the beta-lactam carbons in clavulanic acid from an unusual thiamine pyrophosphate-mediated reaction
Authors: Khaleeli, N Li, RF Townsend, CA
Citation: N. Khaleeli et al., Origin of the beta-lactam carbons in clavulanic acid from an unusual thiamine pyrophosphate-mediated reaction, J AM CHEM S, 121(39), 1999, pp. 9223-9224
Silyl triflate-mediated ring-closure and rearrangement in the synthesis ofpotential bisfuran-containing intermediates of aflatoxin biosynthesis
Authors: Graybill, TL Casillas, EG Pal, K Townsend, CA
Citation: Tl. Graybill et al., Silyl triflate-mediated ring-closure and rearrangement in the synthesis ofpotential bisfuran-containing intermediates of aflatoxin biosynthesis, J AM CHEM S, 121(34), 1999, pp. 7729-7746
Inhibitors of an AdoMet-dependent 3-amino-3-carboxypropyl transferase and their use as ligands for protein affinity chromatography
Authors: Reeve, AM Townsend, CA
Citation: Am. Reeve et Ca. Townsend, Inhibitors of an AdoMet-dependent 3-amino-3-carboxypropyl transferase and their use as ligands for protein affinity chromatography, TETRAHEDRON, 54(52), 1998, pp. 15959-15974
Dedicated to Professor Alastair Ian Scott - Preface
Authors: Townsend, CA
Citation: Ca. Townsend, Dedicated to Professor Alastair Ian Scott - Preface, TETRAHEDRON, 54(52), 1998, pp. VII-VII
Substrate binding to the alpha-ketoglutarate-dependent non-heme iron enzyme clavaminate synthase 2: Coupling mechanism of oxidative decarboxylation and hydroxylation
Authors: Zhou, J Gunsior, M Bachmann, BO Townsend, CA Solomon, EI
Citation: J. Zhou et al., Substrate binding to the alpha-ketoglutarate-dependent non-heme iron enzyme clavaminate synthase 2: Coupling mechanism of oxidative decarboxylation and hydroxylation, J AM CHEM S, 120(51), 1998, pp. 13539-13540
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