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Results: 1-24 |
Results: 24
Antioxidants: biochemical facts and perspectives
Authors: Vermeulen, NPE
Citation: Npe. Vermeulen, Antioxidants: biochemical facts and perspectives, ENV TOX PH, 10(4), 2001, pp. 137-137
Trichloroethylene risk assessment: Relevance of interindividual differences
Authors: Vermeulen, NPE van Bladeren, PJ
Citation: Npe. Vermeulen et Pj. Van Bladeren, Trichloroethylene risk assessment: Relevance of interindividual differences, HUM ECOL R, 7(4), 2001, pp. 717-726
Paracetamol (acetaminophen)-induced toxicity: Molecular and biochemical mechanisms, analogues and protective approaches
Authors: Bessems, JGM Vermeulen, NPE
Citation: Jgm. Bessems et Npe. Vermeulen, Paracetamol (acetaminophen)-induced toxicity: Molecular and biochemical mechanisms, analogues and protective approaches, CR R TOXIC, 31(1), 2001, pp. 55-138
Bioactivation of chemopreventive selenocysteine Se-conjugates and related amino acids by amino acid oxidases novel route of metabolism of selenoaminoacids
Authors: Rooseboom, M Vermeulen, NPE van Hemert, N Commandeur, JNM
Citation: M. Rooseboom et al., Bioactivation of chemopreventive selenocysteine Se-conjugates and related amino acids by amino acid oxidases novel route of metabolism of selenoaminoacids, CHEM RES T, 14(8), 2001, pp. 996-1005
Selenoxidation by flavin-containing monooxygenases as a novel pathway for beta-elimination of selenocysteine Se-conjugates
Authors: Rooseboom, M Commandeur, JNM Floor, GC Rettie, AE Vermeulen, NPE
Citation: M. Rooseboom et al., Selenoxidation by flavin-containing monooxygenases as a novel pathway for beta-elimination of selenocysteine Se-conjugates, CHEM RES T, 14(1), 2001, pp. 127-134
Study on the cytochrome P-450-and glutathione-dependent biotransformation of trichloroethylene in humans
Authors: Bloemen, LJ Monster, AC Kezic, S Commandeur, JNM Veulemans, H Vermeulen, NPE Wilmer, JW
Citation: Lj. Bloemen et al., Study on the cytochrome P-450-and glutathione-dependent biotransformation of trichloroethylene in humans, INT A OCCUP, 74(2), 2001, pp. 102-108
Midazolam is a phenobarbital-like cytochrome P450 inducer in rats
Authors: 't Hoen, PAC Bijsterbosch, MK Van Berkel, TJC Vermeulen, NPE Commandeur, JNM
Citation: Pac. 'T Hoen et al., Midazolam is a phenobarbital-like cytochrome P450 inducer in rats, J PHARM EXP, 299(3), 2001, pp. 921-927
Characterization of thioether compounds formed from alkaline degradation products of enflurane
Authors: Orhan, H Vermeulen, NPE Sahin, G Commandeur, JNM
Citation: H. Orhan et al., Characterization of thioether compounds formed from alkaline degradation products of enflurane, ANESTHESIOL, 95(1), 2001, pp. 165-175
Heterologous expression of xenobiotic mammalian-metabolizing enzymes in mutagenicity tester bacteria: An update and practical considerations
Authors: Kranendonk, M Laires, A Rueff, J Estabrook, RW Vermeulen, NPE
Citation: M. Kranendonk et al., Heterologous expression of xenobiotic mammalian-metabolizing enzymes in mutagenicity tester bacteria: An update and practical considerations, CR R TOXIC, 30(3), 2000, pp. 287-306
Evaluation of a novel high-throughput assay for cytochrome P450 2D6 using 7-methoxy-4-(aminomethyl)-coumarin
Authors: Venhorst, J Onderwater, RCA Meerman, JHN Vermeulen, NPE Commandeur, JNM
Citation: J. Venhorst et al., Evaluation of a novel high-throughput assay for cytochrome P450 2D6 using 7-methoxy-4-(aminomethyl)-coumarin, EUR J PH SC, 12(2), 2000, pp. 151-158
A physiologically-based pharmacokinetic (PB-PK) model for ethylene dibromide: relevance of extrahepatic metabolism
Authors: Hissink, AM Wormhoudt, LW Sherratt, PJ Hayes, JD Commandeur, JNM Vermeulen, NPE van Bladeren, PJ
Citation: Am. Hissink et al., A physiologically-based pharmacokinetic (PB-PK) model for ethylene dibromide: relevance of extrahepatic metabolism, FOOD CHEM T, 38(8), 2000, pp. 707-716
Influence of N-substitution of 7-methoxy-4-(aminomethyl)-coumarin on cytochrome P450 metabolism and selectivity
Authors: Venhorst, J Onderwater, RCA Meerman, JHN Commandeur, JNM Vermeulen, NPE
Citation: J. Venhorst et al., Influence of N-substitution of 7-methoxy-4-(aminomethyl)-coumarin on cytochrome P450 metabolism and selectivity, DRUG META D, 28(12), 2000, pp. 1524-1532
Regioselective hydroxylation of debrisoquine by cytochrome P4502D6: implications for active site modelling
Authors: Lightfoot, T Ellis, SW Mahling, J Ackland, MJ Blaney, FE Bijloo, GJ De Groot, MJ Vermeulen, NPE Blackburn, GM Lennard, MS Tucker, GT
Citation: T. Lightfoot et al., Regioselective hydroxylation of debrisoquine by cytochrome P4502D6: implications for active site modelling, XENOBIOTICA, 30(3), 2000, pp. 219-233
Bioactivation of selenocysteine Se-conjugates by a highly purified rat renal cysteine conjugate beta-lyase/glutamine transaminase K
Authors: Commandeur, JNM Andreadou, I Rooseboom, M Out, M De Leur, LJ Groot, E Vermeulen, NPE
Citation: Jnm. Commandeur et al., Bioactivation of selenocysteine Se-conjugates by a highly purified rat renal cysteine conjugate beta-lyase/glutamine transaminase K, J PHARM EXP, 294(2), 2000, pp. 753-761
Evaluation of the kinetics of beta-elimination reactions of selenocysteineSe-conjugates in human renal cytosol: possible implications for the use askidney selective prodrugs
Authors: Rooseboom, M Vermeulen, NPE Andreadou, I Commandeur, JNM
Citation: M. Rooseboom et al., Evaluation of the kinetics of beta-elimination reactions of selenocysteineSe-conjugates in human renal cytosol: possible implications for the use askidney selective prodrugs, J PHARM EXP, 294(2), 2000, pp. 762-769
Selective induction of cytochrome P450 3A1 by dexamethasone in cultured rat hepatocytes - Analysis with a novel reverse transcriptase-polymerase chain reaction assay
Authors: 't Hoen, PAC Commandeur, JNM Vermeulen, NPE Van Berkel, TJC Bijsterbosch, MK
Citation: Pac. 'T Hoen et al., Selective induction of cytochrome P450 3A1 by dexamethasone in cultured rat hepatocytes - Analysis with a novel reverse transcriptase-polymerase chain reaction assay, BIOCH PHARM, 60(10), 2000, pp. 1509-1518
Escherichia coli MTC, a human NADPH P450 reductase competent mutagenicity tester strain for the expression of human cytochrome P450 isoforms 1A1, 1A2, 2A6, 3A4, or 3A5: catalytic activities and mutagenicity studies
Authors: Kranendonk, M Carreira, F Theisen, P Laires, A Fisher, CW Rueff, J Estabrook, RW Vermeulen, NPE
Citation: M. Kranendonk et al., Escherichia coli MTC, a human NADPH P450 reductase competent mutagenicity tester strain for the expression of human cytochrome P450 isoforms 1A1, 1A2, 2A6, 3A4, or 3A5: catalytic activities and mutagenicity studies, MUT RES-GTE, 441(1), 1999, pp. 73-83
Escherichia coli MTC, a NADPH cytochrome P450 reductase competent mutagenicity tester strain for the expression of human cytochrome P450: Comparison of three types of expression systems
Authors: Kranendonk, M Fisher, CW Roda, R Carreira, F Theisen, P Laires, A Rueff, J Vermeulen, NPE Estabrook, RW
Citation: M. Kranendonk et al., Escherichia coli MTC, a NADPH cytochrome P450 reductase competent mutagenicity tester strain for the expression of human cytochrome P450: Comparison of three types of expression systems, MUT RES-GTE, 439(2), 1999, pp. 287-300
Genetic polymorphisms of human N-acetyltransferase, cytochrome P450, glutathione-S-Transferase, and epoxide hydrolase enzymes: Relevance to xenobiotic metabolism and toxicity
Authors: Wormhoudt, LW Commandeur, JNM Vermeulen, NPE
Citation: Lw. Wormhoudt et al., Genetic polymorphisms of human N-acetyltransferase, cytochrome P450, glutathione-S-Transferase, and epoxide hydrolase enzymes: Relevance to xenobiotic metabolism and toxicity, CR R TOXIC, 29(1), 1999, pp. 59-124
Design, synthesis, and characterization of 7-methoxy-4-(aminomethyl)coumarin as a novel and selective cytochrome P450 2D6 substrate suitable for high-throughput screening
Authors: Onderwater, RCA Venhorst, J Commandeur, JNM Vermeulen, NPE
Citation: Rca. Onderwater et al., Design, synthesis, and characterization of 7-methoxy-4-(aminomethyl)coumarin as a novel and selective cytochrome P450 2D6 substrate suitable for high-throughput screening, CHEM RES T, 12(7), 1999, pp. 555-559
Activation of microsomal glutathione S-transferase and inhibition of cytochrome P450 1A1 activity as a model system for detecting protein alkylation by thiourea-containing compounds in rat liver microsomes
Authors: Onderwater, RCA Commandeur, JNM Menge, WNPB Vermeulen, NPE
Citation: Rca. Onderwater et al., Activation of microsomal glutathione S-transferase and inhibition of cytochrome P450 1A1 activity as a model system for detecting protein alkylation by thiourea-containing compounds in rat liver microsomes, CHEM RES T, 12(5), 1999, pp. 396-402
Biomarkers of free radical damage applications in experimental animals andin humans
Authors: De Zwart, LL Meerman, JHN Commandeur, JNM Vermeulen, NPE
Citation: Ll. De Zwart et al., Biomarkers of free radical damage applications in experimental animals andin humans, FREE RAD B, 26(1-2), 1999, pp. 202-226
Bioassays for the detection of chemicals that can form bioactivation-dependent reactive free radicals
Authors: Sanderson, JT Commandeur, JNM van Wezel, A Vermeulen, NPE
Citation: Jt. Sanderson et al., Bioassays for the detection of chemicals that can form bioactivation-dependent reactive free radicals, ENV TOX CH, 18(6), 1999, pp. 1236-1243
Urinary excretion of biomarkers for radical-induced damage in rats treatedwith NDMA or diquat and the effects of calcium carbimide co-administration
Authors: de Zwart, LL Vermeulen, NPE Hermanns, RCA Commandeur, JNM Salemink, PJM Meerman, JHN
Citation: Ll. De Zwart et al., Urinary excretion of biomarkers for radical-induced damage in rats treatedwith NDMA or diquat and the effects of calcium carbimide co-administration, CHEM-BIO IN, 117(2), 1999, pp. 151-172
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