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Results: 1-25 | 26-48
Results: 1-25/48
Identification of a subtype selective human PPAR alpha agonist through parallel-array synthesis
Authors: Brown, PJ Stuart, LW Hurley, KP Lewis, MC Winegar, DA Wilson, JG Wilkinson, WO Ittoop, OR Willson, TM
Citation: Pj. Brown et al., Identification of a subtype selective human PPAR alpha agonist through parallel-array synthesis, BIOORG MED, 11(9), 2001, pp. 1225-1227
Synthesis and biological activity of L-tyrosine-based PPAR gamma agonists with reduced molecular weight
Authors: Liu, KG Lambert, MH Ayscue, AH Henke, BR Leesnitzer, LM Oliver, WR Plunket, KD Xu, HE Sternbach, DD Willson, TM
Citation: Kg. Liu et al., Synthesis and biological activity of L-tyrosine-based PPAR gamma agonists with reduced molecular weight, BIOORG MED, 11(24), 2001, pp. 3111-3113
Identification of a series of PPAR-gamma/delta dual agonists via solid-phase parallel synthesis
Authors: Liu, KG Lambert, MH Leesnitzer, LM Oliver, W Ott, RJ Plunket, KD Stuart, LW Brown, PJ Willson, TM Sternbach, DD
Citation: Kg. Liu et al., Identification of a series of PPAR-gamma/delta dual agonists via solid-phase parallel synthesis, BIOORG MED, 11(22), 2001, pp. 2959-2962
Identification of a series of oxadiazole-substituted alpha-isopropoxy phenylpropanoic acids with activity on PPAR alpha, PPAR-gamma, and PPAR delta
Authors: Liu, KG Smith, JS Ayscue, AH Henke, BR Lambert, MH Leesnitzer, LM Plunket, KD Willson, TM Sternbach, DD
Citation: Kg. Liu et al., Identification of a series of oxadiazole-substituted alpha-isopropoxy phenylpropanoic acids with activity on PPAR alpha, PPAR-gamma, and PPAR delta, BIOORG MED, 11(17), 2001, pp. 2385-2388
Farnesoid X-activated receptor induces apolipoprotein C-II transcription: a molecular mechanism linking plasma triglyceride levels to bile acids
Authors: Kast, HR Nguyen, CM Sinal, CJ Jones, SA Laffitte, BA Reue, K Gonzalez, FJ Willson, TM Edwards, PA
Citation: Hr. Kast et al., Farnesoid X-activated receptor induces apolipoprotein C-II transcription: a molecular mechanism linking plasma triglyceride levels to bile acids, MOL ENDOCR, 15(10), 2001, pp. 1720-1728
Differential involvement of peroxisome-proliferator-activated receptors alpha and delta in fibrate and fatty-acid-mediated inductions of the gene encoding liver fatty-acid-binding protein in the liver and the small intestine
Authors: Poirer, H Niot, I Monnot, MC Braissant, O Meunier-Durmort, C Costet, P Pineau, T Wahl, W Willson, TM Besnard, P
Citation: H. Poirer et al., Differential involvement of peroxisome-proliferator-activated receptors alpha and delta in fibrate and fatty-acid-mediated inductions of the gene encoding liver fatty-acid-binding protein in the liver and the small intestine, BIOCHEM J, 355, 2001, pp. 481-488
Chemical genomics: Functional analysis of orphan nuclear receptors in the regulation of bile acid metabolism
Authors: Willson, TM Jones, SA Moore, JT Kliewer, SA
Citation: Tm. Willson et al., Chemical genomics: Functional analysis of orphan nuclear receptors in the regulation of bile acid metabolism, MED RES REV, 21(6), 2001, pp. 513-522
Regulation of xenobiotic metabolism by orphan nuclear receptors
Authors: Miller, RT Willson, TM
Citation: Rt. Miller et Tm. Willson, Regulation of xenobiotic metabolism by orphan nuclear receptors, TOX PATHOL, 29(1), 2001, pp. 3-5
Peroxisome proliferator-activated receptors: From genes to physiology
Authors: Kliewer, SA Xu, HE Lambert, MH Willson, TM
Citation: Sa. Kliewer et al., Peroxisome proliferator-activated receptors: From genes to physiology, REC PROG H, 56, 2001, pp. 239-263
Peroxisome proliferator-activated receptor gamma and metabolic disease
Authors: Willson, TM Lambert, MH Kliewer, SA
Citation: Tm. Willson et al., Peroxisome proliferator-activated receptor gamma and metabolic disease, ANN R BIOCH, 70, 2001, pp. 341-367
The human nuclear xenobiotic receptor PXR: Structural determinants of directed promiscuity
Authors: Watkins, RE Wisely, GB Moore, LB Collins, JL Lambert, MH Williams, SP Willson, TM Kliewer, SA Redinbo, MR
Citation: Re. Watkins et al., The human nuclear xenobiotic receptor PXR: Structural determinants of directed promiscuity, SCIENCE, 292(5525), 2001, pp. 2329-2333
A selective peroxisome proliferator-activated receptor delta agonist promotes reverse cholesterol transport
Authors: Oliver, WR Shenk, JL Snaith, MR Russell, CS Plunket, KD Bodkin, NL Lewis, MC Winegar, DA Sznaidman, ML Lambert, MH Xu, HE Sternbach, DD Kliewer, SA Hansen, BC Willson, TM
Citation: Wr. Oliver et al., A selective peroxisome proliferator-activated receptor delta agonist promotes reverse cholesterol transport, P NAS US, 98(9), 2001, pp. 5306-5311
IL-4 inhibits osteoclast formation through a direct action on osteoclast precursors via peroxisome proliferator-activated receptor gamma 1
Authors: Bendixen, AC Shevde, NK Dienger, KM Willson, TM Funk, CD Pike, JW
Citation: Ac. Bendixen et al., IL-4 inhibits osteoclast formation through a direct action on osteoclast precursors via peroxisome proliferator-activated receptor gamma 1, P NAS US, 98(5), 2001, pp. 2443-2448
Structural determinants of ligand binding selectivity between the peroxisome proliferator-activated receptors
Authors: Xu, HE Lambert, MH Montana, VG Plunket, KD Moore, LB Collins, JB Oplinger, JA Kliewer, SA Gampe, RT McKee, DD Moore, JT Willson, TM
Citation: He. Xu et al., Structural determinants of ligand binding selectivity between the peroxisome proliferator-activated receptors, P NAS US, 98(24), 2001, pp. 13919-13924
Pharmacophore analysis of the nuclear oxysterol receptor LXR alpha
Authors: Spencer, TA Li, DS Russel, JS Collins, JL Bledsoe, RK Consler, TG Moore, LB Galardi, CM McKee, DD Moore, JT Watson, MA Parks, DJ Lambert, MH Willson, TM
Citation: Ta. Spencer et al., Pharmacophore analysis of the nuclear oxysterol receptor LXR alpha, J MED CHEM, 44(6), 2001, pp. 886-897
Peroxisome proliferator-activated receptor gamma inhibits transforming growth factor beta-induced connective tissue growth factor expression in humanaortic smooth muscle cells by interfering with Smad3
Authors: Fu, MG Zhang, JF Zhu, XJ Myles, DE Willson, TM Liu, XD Chen, YQE
Citation: Mg. Fu et al., Peroxisome proliferator-activated receptor gamma inhibits transforming growth factor beta-induced connective tissue growth factor expression in humanaortic smooth muscle cells by interfering with Smad3, J BIOL CHEM, 276(49), 2001, pp. 45888-45894
Liver X receptor (LXR) regulation of the LMR alpha gene in human macrophages
Authors: Whitney, KD Watson, MA Goodwin, B Galardi, CM Maglich, JM Wilson, JG Willson, TM Collins, JL Kliewer, SA
Citation: Kd. Whitney et al., Liver X receptor (LXR) regulation of the LMR alpha gene in human macrophages, J BIOL CHEM, 276(47), 2001, pp. 43509-43515
Target genes of peroxisome proliferator-activated receptor gamma in colorectal cancer cells
Authors: Gupta, RA Brockman, JA Sarraf, P Willson, TM DuBois, RN
Citation: Ra. Gupta et al., Target genes of peroxisome proliferator-activated receptor gamma in colorectal cancer cells, J BIOL CHEM, 276(32), 2001, pp. 29681-29687
Adipose tissue resistin expression is severely suppressed in obesity and stimulated by peroxisome proliferator-activated receptor gamma agonists
Authors: Way, JM Gorgun, CZ Tong, Q Uysal, KT Brown, KK Harrington, WW Oliver, WR Willson, TM Kliewer, SA Hotamisligil, GS
Citation: Jm. Way et al., Adipose tissue resistin expression is severely suppressed in obesity and stimulated by peroxisome proliferator-activated receptor gamma agonists, J BIOL CHEM, 276(28), 2001, pp. 25651-25653
Comprehensive messenger ribonucleic acid profiling reveals that peroxisomeproliferator-activated receptor gamma activation has coordinate effects ongene expression in multiple insulin-sensitive tissues
Authors: Way, JM Harrington, WW Brown, KK Gottschalk, WK Sundseth, SS Mansfield, TA Ramachandran, RK Willson, TM Kliewer, SA
Citation: Jm. Way et al., Comprehensive messenger ribonucleic acid profiling reveals that peroxisomeproliferator-activated receptor gamma activation has coordinate effects ongene expression in multiple insulin-sensitive tissues, ENDOCRINOL, 142(3), 2001, pp. 1269-1277
Circumventing tamoxifen resistance in breast cancers using antiestrogens that induce unique conformational changes in the estrogen receptor
Authors: Connor, CE Norris, JD Broadwater, G Willson, TM Gottardis, MM Dewhirst, MW McDonnell, DP
Citation: Ce. Connor et al., Circumventing tamoxifen resistance in breast cancers using antiestrogens that induce unique conformational changes in the estrogen receptor, CANCER RES, 61(7), 2001, pp. 2917-2922
A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis
Authors: Goodwin, B Jones, SA Price, RR Watson, MA McKee, DD Moore, LB Galardi, C Wilson, JG Lewis, MC Roth, ME Maloney, PR Willson, TM Kliewer, SA
Citation: B. Goodwin et al., A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis, MOL CELL, 6(3), 2000, pp. 517-526
Asymmetry in the PPAR gamma/RXR alpha crystal structure reveals the molecular basis of heterodimerization among nuclear receptors
Authors: Gampe, RT Montana, VG Lambert, MH Miller, AB Bledsoe, RK Milburn, MV Kliewer, SA Willson, TM Xu, HE
Citation: Rt. Gampe et al., Asymmetry in the PPAR gamma/RXR alpha crystal structure reveals the molecular basis of heterodimerization among nuclear receptors, MOL CELL, 5(3), 2000, pp. 545-555
A synthetic triterpenoid, 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid (CDDO), is a ligand for the peroxisome proliferator-activated receptor gamma
Authors: Wang, YP Porter, WW Suh, NJ Honda, T Gribble, GW Leesnitzer, LM Plunket, KD Mangelsdorf, DJ Blanchard, SG Willson, TM Sporn, MB
Citation: Yp. Wang et al., A synthetic triterpenoid, 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid (CDDO), is a ligand for the peroxisome proliferator-activated receptor gamma, MOL ENDOCR, 14(10), 2000, pp. 1550-1556
The pregnane x receptor: A promiscuous xenobiotic receptor that has diverged during evolution
Authors: Jones, SA Moore, LB Shenk, JL Wisely, GB Hamilton, GA McKee, DD Tomkinson, NCO LeCluyse, EL Lambert, MH Willson, TM Kliewer, SA Moore, JT
Citation: Sa. Jones et al., The pregnane x receptor: A promiscuous xenobiotic receptor that has diverged during evolution, MOL ENDOCR, 14(1), 2000, pp. 27-39
Risultati: 1-25 | 26-48