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Results: 1-20 |
Results: 20
Presenilins as therapeutic targets for the treatment of Alzheimer's disease
Authors: Golde, TE Younkin, SG
Citation: Te. Golde et Sg. Younkin, Presenilins as therapeutic targets for the treatment of Alzheimer's disease, TRENDS MO M, 7(6), 2001, pp. 264-269
The 'Arctic' APP mutation (E693G) causes Alzheimer's disease by enhanced Abeta protofibril formation
Authors: Nilsberth, C Westlind-Danielsson, A Eckman, CB Condron, MM Axelman, K Forsell, C Stenh, C Luthman, J Teplow, DB Younkin, SG Naslund, J Lannfelt, L
Citation: C. Nilsberth et al., The 'Arctic' APP mutation (E693G) causes Alzheimer's disease by enhanced Abeta protofibril formation, NAT NEUROSC, 4(9), 2001, pp. 887-893
Amyloid beta vaccination: reduced plaques and improved cognition
Authors: Younkin, SG
Citation: Sg. Younkin, Amyloid beta vaccination: reduced plaques and improved cognition, NAT MED, 7(1), 2001, pp. 18-19
Reduction of A beta accumulation in the Tg2576 animal model of Alzheimer'sdisease after oral administration of the phosphatidyl-inositol kinase inhibitor wortmannin
Authors: Haugabook, SJ Le, T Yager, D Zenk, B Healy, BM Eckman, EA Prada, C Younkin, L Murphy, P Pinnix, I Onstead, L Sambamurti, K Golde, TE Dickson, D Younkin, SG Eckman, CB
Citation: Sj. Haugabook et al., Reduction of A beta accumulation in the Tg2576 animal model of Alzheimer'sdisease after oral administration of the phosphatidyl-inositol kinase inhibitor wortmannin, FASEB J, 15(1), 2001, pp. 16-18
Heritability of plasma amyloid beta in typical late-onset Alzheimer's disease pedigrees
Authors: Ertekin-Taner, N Graff-Radford, N Younkin, LH Eckman, C Adamson, J Schaid, DJ Blangero, J Hutton, M Younkin, SG
Citation: N. Ertekin-taner et al., Heritability of plasma amyloid beta in typical late-onset Alzheimer's disease pedigrees, GENET EPID, 21(1), 2001, pp. 19-30
Age-dependent changes in brain, CSF, and plasma amyloid beta protein in the Tg2576 transgenic mouse model of Alzheimer's disease
Authors: Kawarabayashi, T Younkin, LH Saido, TC Shoji, M Ashe, KH Younkin, SG
Citation: T. Kawarabayashi et al., Age-dependent changes in brain, CSF, and plasma amyloid beta protein in the Tg2576 transgenic mouse model of Alzheimer's disease, J NEUROSC, 21(2), 2001, pp. 372-381
Reduced effectiveness of A beta 1-42 immunization in APP transgenic mice with significant amyloid deposition
Authors: Das, P Murphy, MP Younkin, LH Younkin, SG Golde, TE
Citation: P. Das et al., Reduced effectiveness of A beta 1-42 immunization in APP transgenic mice with significant amyloid deposition, NEUROBIOL A, 22(5), 2001, pp. 721-727
High throughput screens for the identification of compounds that alter theaccumulation of the Alzheimer's amyloid beta peptide (A beta)
Authors: Haugabook, SJ Yager, DM Eckman, EA Golde, TE Younkin, SG Eckman, CB
Citation: Sj. Haugabook et al., High throughput screens for the identification of compounds that alter theaccumulation of the Alzheimer's amyloid beta peptide (A beta), J NEUROSC M, 108(2), 2001, pp. 171-179
Brain A beta amyloidosis in APPsw mice induces accumulation of presenilin-I and tau
Authors: Tomidokoro, Y Harigaya, Y Matsubara, E Ikeda, M Kawarabayashi, T Shirao, T Ishiguro, K Okamoto, K Younkin, SG Shoji, M
Citation: Y. Tomidokoro et al., Brain A beta amyloidosis in APPsw mice induces accumulation of presenilin-I and tau, J PATHOLOGY, 194(4), 2001, pp. 500-506
Plasma beta-amyloid as a surrogate genetic marker in late-onset Alzheimer's disease
Authors: Ertekin-Taner, N Graff-Radford, N Younkin, LH Eckman, C Adamson, J Schaid, DJ Blangero, J Hutton, M Younkin, SG
Citation: N. Ertekin-taner et al., Plasma beta-amyloid as a surrogate genetic marker in late-onset Alzheimer's disease, ALZHEIMER'S DISEASE, 2001, pp. 303-310
Selective increase in cellular A beta 42 is related to apoptosis but not necrosis
Authors: Ohyagi, Y Yamada, T Nishioka, K Clarke, NJ Tomlinson, AJ Naylor, S Nakabeppu, Y Kira, J Younkin, SG
Citation: Y. Ohyagi et al., Selective increase in cellular A beta 42 is related to apoptosis but not necrosis, NEUROREPORT, 11(1), 2000, pp. 167-171
Biochemical detection of A beta isoforms: implications for pathogenesis, diagnosis, and treatment of Alzheimer's disease
Authors: Golde, TE Eckman, CB Younkin, SG
Citation: Te. Golde et al., Biochemical detection of A beta isoforms: implications for pathogenesis, diagnosis, and treatment of Alzheimer's disease, BBA-MOL BAS, 1502(1), 2000, pp. 172-187
Differences in the A beta 40/A beta 42 ratio associated with cerebrospinalfluid lipoproteins as a function of apolipoprotein E genotype
Authors: Fagan, AM Younkin, LH Morris, JC Fryer, JD Cole, TG Younkin, SG Holtzman, DM
Citation: Am. Fagan et al., Differences in the A beta 40/A beta 42 ratio associated with cerebrospinalfluid lipoproteins as a function of apolipoprotein E genotype, ANN NEUROL, 48(2), 2000, pp. 201-210
Linkage of plasma A beta 42 to a quantitative locus on chromosome 10 in late-onset Alzheimer's disease pedigrees
Authors: Ertekin-Taner, N Graff-Radford, N Younkin, LH Eckman, C Baker, M Adamson, J Ronald, J Blangero, J Hutton, M Younkin, SG
Citation: N. Ertekin-taner et al., Linkage of plasma A beta 42 to a quantitative locus on chromosome 10 in late-onset Alzheimer's disease pedigrees, SCIENCE, 290(5500), 2000, pp. 2303
Mayo and the mouse
Authors: Younkin, SG Stoddard, S
Citation: Sg. Younkin et S. Stoddard, Mayo and the mouse, NATURE, 404(6780), 2000, pp. 809-809
Amyloid beta protein starting pyroglutamate at position 3 is a major component of the amyloid deposits in the Alzheimer's disease brain
Authors: Harigaya, Y Saido, TC Eckman, CB Prada, CM Shoji, M Younkin, SG
Citation: Y. Harigaya et al., Amyloid beta protein starting pyroglutamate at position 3 is a major component of the amyloid deposits in the Alzheimer's disease brain, BIOC BIOP R, 276(2), 2000, pp. 422-427
Impaired synaptic plasticity and learning in aged amyloid precursor protein transgenic mice
Authors: Chapman, PF White, GL Jones, MW Cooper-Blacketer, D Marshall, VJ Irizarry, M Younkin, L Good, MA Bliss, TVP Hyman, BT Younkin, SG Hsiao, KK
Citation: Pf. Chapman et al., Impaired synaptic plasticity and learning in aged amyloid precursor protein transgenic mice, NAT NEUROSC, 2(3), 1999, pp. 271-276
Evidence for glial-mediated inflammation in aged APP(SW) transgenic mice
Authors: Benzing, WC Wujek, JR Ward, EK Shaffer, D Ashe, KH Younkin, SG Brunden, KR
Citation: Wc. Benzing et al., Evidence for glial-mediated inflammation in aged APP(SW) transgenic mice, NEUROBIOL A, 20(6), 1999, pp. 581-589
Antisense-induced reduction of presenilin 1 expression selectively increases the production of amyloid beta 42 in transfected cells
Authors: Refolo, LM Eckman, C Prada, CM Yager, D Sambamurti, K Mehta, N Hardy, J Younkin, SG
Citation: Lm. Refolo et al., Antisense-induced reduction of presenilin 1 expression selectively increases the production of amyloid beta 42 in transfected cells, J NEUROCHEM, 73(6), 1999, pp. 2383-2388
Glycosylphosphatidylinositol-anchored proteins play an important role in the biogenesis of the Alzheimer's amyloid beta-protein
Authors: Sambamurti, K Sevlever, D Koothan, T Refolo, LM Pinnix, I Gandhi, S Onstead, L Younkin, L Prada, CM Yager, D Ohyagi, Y Eckman, CB Rosenberry, TL Younkin, SG
Citation: K. Sambamurti et al., Glycosylphosphatidylinositol-anchored proteins play an important role in the biogenesis of the Alzheimer's amyloid beta-protein, J BIOL CHEM, 274(38), 1999, pp. 26810-26814
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