NEW TOLUIDINE DERIVATIVES WITH ANTIMYCOBACTERIAL AND ANTIFUNGAL ACTIVITIES

We have prepared a series of toluidine derivatives and some of them sh owed an interesting in vitro activity against Mycobacterium tuberculos is. All compounds showed good activity against M.avium, some of them w ere more potent than the streptomycin and isoniazid used as controls. Moreover, newly synthesized compounds were tested for antibacterial an d antifungal activities and some of them exhibited moderate activity a gainst S.aureus, Candida albicans, Candida sp., Cryptococcus neoforman s and isolates of plant pathogenic fungi. Compound 5a (2-metilen-imida zol-1-yl-N-cinnamyl-aniline) is particularly active on all the tested microorganisms.