MORPHINE ALKALOIDS .141. SYNTHESIS AND OPIOID BINDING-PROPERTIES OF NEW BETA-FUNALTREXAMINE (BETA-FNA) ANALOGS

Authors
SIMON C HOSZTAFI S MAKLEIT S MARKI A BENYHE S BORSODI A
Citation
C. Simon et al., MORPHINE ALKALOIDS .141. SYNTHESIS AND OPIOID BINDING-PROPERTIES OF NEW BETA-FUNALTREXAMINE (BETA-FNA) ANALOGS, Medicinal chemistry research, 7(4), 1997, pp. 251-258
Citations number
17
Categorie Soggetti
Chemistry Medicinal
Journal title
Medicinal chemistry research → ACNP
ISSN journal
10542523
Volume
7
Issue
4
Year of publication
1997
Pages
251 - 258
Database
ISI
SICI code
1054-2523(1997)7:4<251:MA.SAO>2.0.ZU;2-L
Abstract
Several 6 beta-chloroacetamido- and 6 beta-monomethylfumaramido-4,5 al pha-epoxy-7,8-didehydro-morphinans and their analogues with saturated ring C were prepared and their binding affinities to mu, delta and kap pa opioid receptors determined. Subtype specifity has also been evalua ted by the aid of labeled selective ligands.