INDUCTION OF MORPHOLOGICAL TRANSFORMATION IN BALB 3T3 MOUSE EMBRYO CELLS BY OKADAIC ACID/

Authors
SHEU CW RODRIGUEZ I DOBRAS SN LEE JK
Citation
Cw. Sheu et al., INDUCTION OF MORPHOLOGICAL TRANSFORMATION IN BALB 3T3 MOUSE EMBRYO CELLS BY OKADAIC ACID/, Food and chemical toxicology, 33(10), 1995, pp. 883-885
Citations number
15
Categorie Soggetti
Toxicology,"Food Science & Tenology
Journal title
Food and chemical toxicology → ACNP
ISSN journal
02786915
Volume
33
Issue
10
Year of publication
1995
Pages
883 - 885
Database
ISI
SICI code
0278-6915(1995)33:10<883:IOMTIB>2.0.ZU;2-B
Abstract
Okadaic acid is produced by several types of dinoflagellates (marine p lankton) and has been implicated as a causative agent of diarrhoetic s hellfish poisoning. Okadaic acid, a known tumour promoter in vivo, has been shown to promote morphological transformation of carcinogen-init iated BALB/3T3 cells. This study shows that okadaic acid is capable of inducing morphological transformation of BALB/3T3 cells in the absenc e of an initiator.