AN EVALUATION OF MUSK XYLENE IN A BATTERY OF GENOTOXICITY TESTS

Authors
API AM FORD RA SAN RHC
Citation
Am. Api et al., AN EVALUATION OF MUSK XYLENE IN A BATTERY OF GENOTOXICITY TESTS, Food and chemical toxicology, 33(12), 1995, pp. 1039-1045
Citations number
8
Categorie Soggetti
Toxicology,"Food Science & Tenology
Journal title
Food and chemical toxicology → ACNP
ISSN journal
02786915
Volume
33
Issue
12
Year of publication
1995
Pages
1039 - 1045
Database
ISI
SICI code
0278-6915(1995)33:12<1039:AEOMXI>2.0.ZU;2-3
Abstract
Musk xylene (CAS no. 81-15-2), a synthetic musk fragrance ingredient, was evaluated in a battery of short-term genotoxicity tests that inclu ded the mouse lymphoma assay, an in vitro cytogenetics assay in Chines e hamster ovary (CHO) cells, the in vitro unscheduled DNA synthesis (U DS) assay in primary rat hepatocytes and an in vivo UDS assay. Musk xy lene gave uniformly negative results in these genotoxicity tests. Thes e observations, combined with previously reported negative Ames tests, suggest a non-genotoxic mechanism for the induction of mouse liver tu mours by musk xylene.