SOLUBILITY, INHIBITED GROWTH AND DISSOLUTION KINETICS OF CALCIUM-OXALATE CRYSTALS IN SOLUTIONS, CONTAINING ALPHA-KETOGLUTARIC ACID

The kinetics of dissolution of calcium oxalate (CaOX) calculi in physi ological solutions containing alpha-ketoglutaric acids at different co ncentrations were studied, using the change in the Archimedean weight of samples immersed in the solution. It was found that alpha-ketogluta ric acid (a normal physiological constituent of urine) acts at increas ed concentrations as a dissolving agent with respect to CaOX calculi. Analysis of the experimental results enabled the determination of the increased solubility of calcium oxalate in the presence of alpha-ketog lutaric acid which can be defined as a new and promising agent for dis solving CaOX calculi in human urine. The inhibiting effect of alpha-ke toglutanic acid on CaOX precipitation in human urine is also discussed .