We obtain a compact exact expression for the strain energy density of
a cubic epitaxial medium in the limit of linear elasticity theory. Onl
y the result for {001} is identical to the isotropic case: the greates
t departure from isotropic theory occurs for {111}. We have evaluated
this difference for a large number of cubic media and have obtained an
estimate of its impact on epilayer critical thickness t(c) for [001]
oriented growth. We suggest that it tends to lower t(c) for [001] orie
nted growth relative to that given by isotropic theory: by 15%-30% for
common semiconductors and by up to a factor of 3 for metals.