Objective: To investigate the variability in basal metabolic rate (BMR
) of women taking the contraceptive pill, through sequential measureme
nt over the course of one menstrual cycle. Design: Randomised. Setting
: Metabolic room, School of Biological and Molecular Sciences, Oxford
Brookes University. Subjects and measurements: BMR of five weight-stab
le women taking the contraceptive pill, was measured three to four tim
es each week for a period of five consecutive weeks. BMR was measured
using a Douglas bag. Results: The pattern of variation in BMR was rand
om for individual subjects throughout the period of measurement. The l
evel of intraindividual variation indicated by the coefficient of vari
ation (CV) ranged from 2.4 to 4.87%. Conclusions: Women taking the con
traceptive pill did not exhibit the cyclicity or variation in BMR obse
rved in some normally ovulating subjects. BMR in women taking the cont
raceptive pill could therefore be considered a 'biological constant'.