Va. Roginsky et al., MODERATE ANTIOXIDATIVE EFFICIENCIES OF FLAVONOIDS DURING PEROXIDATIONOF METHYL LINOLEATE IN HOMOGENEOUS AND MICELLAR SOLUTIONS, Journal of the American Oil Chemists' Society, 73(6), 1996, pp. 777-786
The relative reactivities as well as the stoichiometric coefficients f
or a number of flavonoids, catechols, and-for comparison-standard phen
olic antioxidants were determined by analyzing the kinetics of oxygen
consumption in organic and micellar systems, with peroxidation initiat
ed by lipid- and water-soluble azo initiators. The results demonstrate
d that the flavonoids did not behave as classic phenolic antioxidants
such as alpha-tocopherol, but showed only moderate chain-breaking acti
vities. The results were in line with other structure-activity relatio
nship studies on the importance of the B-ring catechol structure, the
2,3-double bond, and the 3,5-hydroxy groups. The data are discussed in
view of possible explanations of the deviations flavonoids reveal in
their behavior compared with regular phenolic antioxidants.