REBALANCING ESSENTIAL AMINO-ACIDS INTAKE BY SELF-SELECTION IN THE RAT

The purpose of the present study was to assess whether rats are capabl e of selecting the right proportions of two diets that are individuall y inappropriate in terms of essential amino acid composition to satisf y their amino acid requirements. Rats were offered a choice of one pro tein-free regimen and another devoid of only one essential amino acid (either threonine or isoleucine) set up in such a way as to provide am ino acid balance if they were consumed in 1/3 and 2/3 proportions resp ectively. Preliminary experiments had established that all our diets w ere aversive by themselves except for the 60 g casein/kg diet. Rats di d reach almost the necessary proportion with, according to published s tandards (National Research Council, 1978), some excess in isoleucine intake. In addition, given access to two aversive diets that were each nutritionally inadequate, rats showed no aversion and gained body wei ght when they had the opportunity to consume both of them. Beyond the capacity that rats have of rebalancing their micronutrient intake, the present experiment brings out the idea that the imbalance-induced ave rsion:preference ratio may be completely upset when this omnivore has access to more than one feed.