HEPATIC AND CARDIAC OXIDATIVE STRESS AND OTHER METABOLIC CHANGES IN BROILERS WITH THE ASCITES SYNDROME

Citation
A. Diazcruz et al., HEPATIC AND CARDIAC OXIDATIVE STRESS AND OTHER METABOLIC CHANGES IN BROILERS WITH THE ASCITES SYNDROME, Poultry science, 75(7), 1996, pp. 900-903
Citations number
26
Categorie Soggetti
Agriculture Dairy & AnumalScience
Journal title
ISSN journal
00325791
Volume
75
Issue
7
Year of publication
1996
Pages
900 - 903
Database
ISI
SICI code
0032-5791(1996)75:7<900:HACOSA>2.0.ZU;2-G
Abstract
The objective of this study was to evaluate the gluconeogenic response of in vitro stimulated hepatocytes from control broilers and broilers with clinical manifestations of the ascites syndrome. The basal rate of glucose synthesis from lactate was found to be threefold greater in sick birds than in the control group and stimulation obtained with ep inephrine was found to be quantitatively similar in both groups. Under basal conditions, the hepatocytes from the sick broilers exhibited 60 % more ammonium than the control birds. In addition, the quantificatio n of thiobarbituric acid reactive substances, as indicators of cellula r Lipoperoxidation, showed an increase of over 100% in heart and liver of sick broilers fowl. In conclusion, the complex integrated response of gluconeogenesis to epinephrine is maintained in broilers with asci tes, although their hepatocytes present changes compatible with those observed in cases of oxidative stress. It is not known whether this st ress is a cause or a consequence of the ascites syndrome.