A-RING MODIFIED TAXANES - 13-AZA DERIVATIVES

Citation
M. Menichincheri et al., A-RING MODIFIED TAXANES - 13-AZA DERIVATIVES, Medicinal chemistry research, 6(4), 1996, pp. 264-292
Citations number
46
ISSN journal
10542523
Volume
6
Issue
4
Year of publication
1996
Pages
264 - 292
Database
ISI
SICI code
1054-2523(1996)6:4<264:AMT-1D>2.0.ZU;2-I
Abstract
A series oi new 13-aza taxanes, having a nitrogen atom al position 13 and consequently leading to side chain attachments other than ester, a re presented In particular the synthesis ai acyloximes, imides and ena mides is reported None of these novel taxanes show activity in the tub ulin polymerization assay or in the in vitro cytoloxicity assay.