The problem of ''regression artifacts'' in causal inference, otherwise
known as the problem of en or and reliable irrelevant variance in ''i
ndependent'' variables used for matching or regression adjustment, is
illustrated first in the time-series data where a treatment is trigger
ed by an extreme measure. The ''offset effect'' in psychotherapy, Unde
rwood's scalloped learning curve, and potential pseudo-effects in AIDS
therapies are used as illustrations. The magnitude of such artifacts
is computable if the autocorrelation pattern for various lags is known
, and thus could be distinguished from genuine effects. For longitudin
al studies in which a population of respondents is repeatedly measured
, the problem of anchoring the matching or regression adjustments on a
single wave of measurement (usually the first) is illustrated as affe
cted by the proximally autocorrelated nature of such measures. Data fr
om a famous study of the effects of job training are reinterpreted in
light of this consideration. Copyright (C) 1996 Elsevier Science Ltd.