CONSTRUCTION OF 3-HELIX MODELS OF THE NICOTINIC RECEPTOR-LIGAND BINDING-SITE

Authors
WESTKAEMPER RB
Citation
Rb. Westkaemper, CONSTRUCTION OF 3-HELIX MODELS OF THE NICOTINIC RECEPTOR-LIGAND BINDING-SITE, Medicinal chemistry research, 6(7-8), 1996, pp. 511-525
Citations number
43
Categorie Soggetti
Chemistry Medicinal
Journal title
Medicinal chemistry research → ACNP
ISSN journal
10542523
Volume
6
Issue
7-8
Year of publication
1996
Pages
511 - 525
Database
ISI
SICI code
1054-2523(1996)6:7-8<511:CO3MOT>2.0.ZU;2-E
Abstract
An outline of a novel approach to modeling components of the nicotinic receptor ligand binding site is presented. The model obtained consist s of three a-helices observed in the low resolution experimental recep tor structure and one interhelix loop. Although the model is not consi dered to be definitive, it is consistent with much of the data from bi ochemical experiments that identifies ligand binding site components.