EFFECTS OF FEEDING FUSARIUM-FUJIKUROI CULTURE MATERIAL, CONTAINING KNOWN LEVELS OF MONILIFORMIN, IN YOUNG BROILER CHICKS

An experiment was conducted with 270 male broiler chicks to evaluate t he effects of a Fusarium fujkuroi M-1214 culture material containing m oniliformin (M) on broiler chicks. Day-old chicks were allotted random ly to dietry treatments containing 0, .24, .48, .72, .96, 1.44, 1.92, 2.40, and 2.88% M culture material (MCM). These levels of MCM supplied 0, 25, 50, 75, 100, 150, 200, 250, or 300 mg M/kg of feed. Each dieta ry treatment was fed to six pen replicates of five chicks per pen for 21 d. Significant mortality (P < .05) occurred in chicks fed 200 (8 ou t of 30), 250 (17 out of 30), and 300 (25 out of 30) mg M/kg feed. Chi cks fed > 100 mg M/kg had lower (P < .05) feed intakes and smaller BW gains (P < .05) than controls. Increased heart weights (P < .05) feed intakes and smaller BW gains (P < .05) than controls. Increased heart weights (P < .05) were observed in chicks fed > 50 mg M/kg, and increa sed liver weights (P < .05) in chicks fed > 100 mg M/kg. Gross lesions of M toxicity included generalized cardiomegaly with dilation of the right ventricle. Histopathology revealed a high incidence of large and variably shaped cardiomyocyte nuclei and a generalized loss of cardio myocyte cross striations in chicks fed > 75 and 200 mg M/kg, respectiv ely. Results indicated that F. fujikuroi culture material containing M is toxic to young broiler chicks.