Although regulations on work hours usually include a minimum weekly re
st period, there is little empirical evidence concerning recovery from
work. Shift-working nurses (N = 61) used a handheld computer for 28 d
ays to complete self-ratings, cognitive-performance tasks, and a deep
diary. Many measures were worse on rest days that followed a night shi
ft rather than a day shift and tended to be worse on first rest days c
ompared with subsequent rest days. Alertness was lowest on the ist res
t day following a night shift. Social satisfaction was better on workd
ays that were preceded by 2 rather than 1 rest day. Reaction time decr
eased over consecutive night shifts and tended to increase over rest d
ays following night shifts. The results are interpreted as being consi
stent with the combined adaptive costs of fatigue and adjustment to an
d from a nocturnal routine. The practical implications for scheduling
rest days are considered.